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ENZYME

ENZYME entry: EC 4.2.3.119

Accepted Name
(-)-alpha-pinene synthase
Alternative Name(s)
(-)-alpha-pinene/(-)-camphene synthase
(-)-alpha-pinene cyclase
Reaction catalysed
(2E)-geranyl diphosphate <=> (1S,5S)-alpha-pinene + diphosphate
Comment(s)
  • Cyclase II of Salvia officinalis (sage) gives about equal parts (-)- alpha-pinene, (-)-beta-pinene and (-)-camphene, plus traces of other monoterpenoids.
  • (3S)-linalyl diphosphate can also be used by the enzyme in preference to (3R)-linalyl diphosphate.
  • The 4-pro-S hydrogen of geranyl diphosphate is lost.
  • The enzyme from Abies grandis (grand fir) gives roughly equal parts (-)-alpha-pinene and (-)-beta-pinene.
  • However the clone ag11 gave 35% (-)-limonene, 24% (-)-alpha-pinene and 20% (-)-beta-phellandrene.
  • Synthase I from Pinus taeda (loblolly pine) produces (-)-alpha-pinene with traces of (-)-beta-pinene.
  • The enzyme from Picea sitchensis (Sika spruce) forms 70% (-)-alpha- pinene and 30% (-)-beta-pinene.
  • The recombinant PmeTPS1 enzyme from Pseudotsuga menziesii (Douglas fir) gave roughly equal proportions of (-)-alpha-pinene and (-)- camphene plus traces of other monoterpenoids.
  • See also EC 4.2.3.120, EC 4.2.3.117, EC 4.2.3.16 and EC 4.2.3.52.
  • Formerly EC 4.1.99.8, EC 4.2.3.14 and EC 4.2.3.n7.
Cross-references
BRENDA4.2.3.119
EC2PDB4.2.3.119
ExplorEnz4.2.3.119
PRIAM enzyme-specific profiles4.2.3.119
KEGG Ligand Database for Enzyme Nomenclature4.2.3.119
IUBMB Enzyme Nomenclature4.2.3.119
IntEnz4.2.3.119
MEDLINEFind literature relating to 4.2.3.119
MetaCyc4.2.3.119
Rhea expert-curated reactions4.2.3.119
UniProtKB/Swiss-Prot
R9QMY8, CAMPS_PINCOF2XF95, PINS1_PICGLF2XFA8, PINS1_PICSI
F2XF96, PINS2_PICGLQ6XDB5, PINS2_PICSIO23945, PINS_FRAVE
Q84KL6, PT1_PINTAR9QMY9, SAPN1_PINBNR9QMR3, SAPN1_PINCO
R9QMR0, SBPN1_PINBNR9QMQ9, SBPN1_PINCOR9QMW5, SBPN2_PINBN
R9QMW1, SPIN1_PINBNO24475, TPSD3_ABIGRQ9M7C9, TPSDB_ABIGR

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