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ENZYME entry: EC 4.2.3.149

Accepted Name
nephthenol synthase.
Reaction catalysed
(2E,6E,10E)-geranylgeranyl diphosphate + H2O <=> (R)-nephthenol + diphosphate
Comment(s)
  • Two isozymes with this activity were isolated from the bacterium Streptomyces sp. SANK 60404.
  • The enzyme encoded by the DtcycA gene also produces cembrene C (see 4.2.3.148), while the enzyme encoded by the DtcycB gene also produces (R)-cembrene A and (1S,4E,8E,12E)-2,2,5,9,13- pentamethylcyclopentadeca-4,8,12-trien-1-ol (cf. EC 4.2.3.150 and EC 4.2.3.151).
Cross-references
BRENDA4.2.3.149
EC2PDB4.2.3.149
ExplorEnz4.2.3.149
PRIAM enzyme-specific profiles4.2.3.149
KEGG Ligand Database for Enzyme Nomenclature4.2.3.149
IUBMB Enzyme Nomenclature4.2.3.149
IntEnz4.2.3.149
MEDLINEFind literature relating to 4.2.3.149
MetaCyc4.2.3.149
Rhea expert-curated reactions4.2.3.149
UniProtKB/Swiss-Prot
M1V9Q0, DTCYA_STRSQ;  M1VDX3, DTCYB_STRSQ;  

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