ENZYME

A new class EC 7, Translocases, has been added to the EC list. It will be part of ENZYME from release 2018_10. Read more about EC 7 here.

ENZYME entry: EC 4.3.1.13

Accepted Name
Carbamoyl-serine ammonia-lyase.
Alternative Name(s)
O-carbamoyl-L-serine deaminase.
Reaction catalysed
O-carbamoyl-L-serine + H(2)O <=> pyruvate + 2 NH(3) + CO(2)
Cofactor(s)
Pyridoxal 5'-phosphate.
Comment(s)
The enzyme cleaves a carbon-oxygen bond, releasing CO(2), ammonia, and an unstable enamine product that tautomerizes to an imine form, which undergoes a hydrolytic deamination to form pyruvate and a second ammonia molecule. The latter reaction, which can occur spontaneously, can also be catalyzed by EC 3.5.99.10.
Cross-references
BRENDA	4.3.1.13
EC2PDB	4.3.1.13
ExplorEnz	4.3.1.13
PRIAM enzyme-specific profiles	4.3.1.13
KEGG Ligand Database for Enzyme Nomenclature	4.3.1.13
IUBMB Enzyme Nomenclature	4.3.1.13
IntEnz	4.3.1.13
MEDLINE	Find literature relating to 4.3.1.13
MetaCyc	4.3.1.13

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