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A new class EC 7, Translocases, has been added to the EC list. It will be part of ENZYME from release 2018_10. Read more about EC 7 here.

ENZYME entry: EC 4.3.1.13

Accepted Name
Carbamoyl-serine ammonia-lyase.
Alternative Name(s)
O-carbamoyl-L-serine deaminase.
Reaction catalysed
O-carbamoyl-L-serine + H(2)O <=> pyruvate + 2 NH(3) + CO(2)
Cofactor(s)
Pyridoxal 5'-phosphate.
Comment(s)
  • The enzyme cleaves a carbon-oxygen bond, releasing CO(2), ammonia, and an unstable enamine product that tautomerizes to an imine form, which undergoes a hydrolytic deamination to form pyruvate and a second ammonia molecule.
  • The latter reaction, which can occur spontaneously, can also be catalyzed by EC 3.5.99.10.
Cross-references
BRENDA4.3.1.13
EC2PDB4.3.1.13
ExplorEnz4.3.1.13
PRIAM enzyme-specific profiles4.3.1.13
KEGG Ligand Database for Enzyme Nomenclature4.3.1.13
IUBMB Enzyme Nomenclature4.3.1.13
IntEnz4.3.1.13
MEDLINEFind literature relating to 4.3.1.13
MetaCyc4.3.1.13

View entry in original ENZYME format
View entry in raw text format (no links)
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 4.3.1.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 4.3.-.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 4.-.-.-