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ENZYME entry: EC 4.3.2.10

Accepted Name
Imidazole glycerol-phosphate synthase.
Alternative Name(s)
IGP synthase.
Reaction catalysed
5-((5-phospho-1-deoxy-D-ribulos-1-ylamino)methylideneamino)-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide + L-glutamine <=> 5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide + D-erythro-1-(imidazol-4-yl)glycerol 3-phosphate + L-glutamate
Comment(s)
  • The enzyme is involved in histidine biosynthesis, as well as purine nucleotide biosynthesis.
  • The enzymes from archaea and bacteria are heterodimeric.
  • A glutaminase component (cf. EC 3.5.1.2) produces an ammonia molecule that is transferred by a 25 A tunnel to a cyclase component, which adds it to the imidazole ring, leading to lysis of the molecule and cyclization of one of the products.
  • The glutminase subunit is only active within the dimeric complex.
  • In fungi and plants the two subunits are combined into a single polypeptide.
Cross-references
BRENDA4.3.2.10
EC2PDB4.3.2.10
ExplorEnz4.3.2.10
PRIAM enzyme-specific profiles4.3.2.10
KEGG Ligand Database for Enzyme Nomenclature4.3.2.10
IUBMB Enzyme Nomenclature4.3.2.10
IntEnz4.3.2.10
MEDLINEFind literature relating to 4.3.2.10
MetaCyc4.3.2.10
UniProtKB/Swiss-Prot
Q9SZ30, HIS4_ARATH;  Q0P8U2, HIS51_CAMJE;  A1W0U9, HIS51_CAMJJ;  
Q5HT90, HIS51_CAMJR;  Q5X6Z7, HIS51_LEGPA;  Q5ZXI1, HIS51_LEGPH;  
Q5WYE9, HIS51_LEGPL;  P61782, HIS51_METMP;  Q3SWE9, HIS51_NITWN;  
Q7V959, HIS51_PROMM;  Q9HU42, HIS51_PSEAE;  Q7U924, HIS51_SYNPX;  
Q7MLS3, HIS51_VIBVY;  Q9PM75, HIS52_CAMJE;  Q5HSJ1, HIS52_CAMJR;  
Q5X5X2, HIS52_LEGPA;  Q5ZW90, HIS52_LEGPH;  Q5WX94, HIS52_LEGPL;  
P61783, HIS52_METMP;  Q3SPZ6, HIS52_NITWN;  Q7V6M5, HIS52_PROMM;  
P72138, HIS52_PSEAE;  Q7U899, HIS52_SYNPX;  Q7MPP4, HIS52_VIBVY;  
Q7MPK8, HIS53_VIBVY;  B0BYP8, HIS5_ACAM1;  Q6F7A7, HIS5_ACIAD;  
P58788, HIS5_AGRFC;  Q5E635, HIS5_ALIF1;  O66943, HIS5_AQUAE;  
O28019, HIS5_ARCFU;  Q5P793, HIS5_AROAE;  P18785, HIS5_AZOBR;  
C3P504, HIS5_BACAA;  C3L9P9, HIS5_BACAC;  A0RBM0, HIS5_BACAH;  
Q81T60, HIS5_BACAN;  B7JFZ3, HIS5_BACC0;  P61778, HIS5_BACC1;  
B7INA1, HIS5_BACC2;  C1EMQ5, HIS5_BACC3;  B7HHG3, HIS5_BACC4;  
B7HKD2, HIS5_BACC7;  A7GMU8, HIS5_BACCN;  B9IUZ8, HIS5_BACCQ;  
Q81G04, HIS5_BACCR;  Q63DX0, HIS5_BACCZ;  Q5LBD5, HIS5_BACFN;  
Q64RT0, HIS5_BACFR;  Q9K6Z4, HIS5_BACHD;  Q6HLE5, HIS5_BACHK;  
Q65EG1, HIS5_BACLD;  A9VLH5, HIS5_BACMK;  A8FHR1, HIS5_BACP2;  
Q5WDI0, HIS5_BACSK;  O34565, HIS5_BACSU;  Q8A7Z4, HIS5_BACTN;  
A7Z964, HIS5_BACVZ;  P60597, HIS5_BDEBA;  Q8G4S6, HIS5_BIFLO;  
Q7VQW7, HIS5_BLOFL;  Q492K0, HIS5_BLOPB;  Q7WDY1, HIS5_BORBR;  
Q7W2Y1, HIS5_BORPA;  Q7VSY8, HIS5_BORPE;  Q89WM6, HIS5_BRADU;  
Q2YQZ0, HIS5_BRUA2;  Q57AH5, HIS5_BRUAB;  Q8YE35, HIS5_BRUME;  
Q8FY09, HIS5_BRUSU;  P57204, HIS5_BUCAI;  Q9ZHE3, HIS5_BUCAP;  
P59501, HIS5_BUCBP;  Q84I56, HIS5_BUCDN;  Q84I55, HIS5_BUCMH;  
Q84I54, HIS5_BUCSC;  Q39K87, HIS5_BURL3;  Q845U9, HIS5_BURM1;  
Q62GE3, HIS5_BURMA;  Q3JN00, HIS5_BURP1;  Q63Q90, HIS5_BURPS;  
Q8R883, HIS5_CALS4;  Q3AD50, HIS5_CARHZ;  Q9A231, HIS5_CAUVC;  
A9WD25, HIS5_CHLAA;  B8G9S3, HIS5_CHLAD;  Q3AT63, HIS5_CHLCH;  
B9LI74, HIS5_CHLSY;  Q8KF56, HIS5_CHLTE;  Q7P0F1, HIS5_CHRVO;  
Q97KI0, HIS5_CLOAB;  Q47XB5, HIS5_COLP3;  P60598, HIS5_CORDI;  
Q8FNZ6, HIS5_COREF;  O69043, HIS5_CORGL;  Q4JW55, HIS5_CORJK;  
Q46WL6, HIS5_CUPPJ;  Q6A8L2, HIS5_CUTAK;  Q9TLQ8, HIS5_CYACA;  
Q85FY4, HIS5_CYAM1;  B8HUR1, HIS5_CYAP4;  P48262, HIS5_CYAPA;  
Q47AM1, HIS5_DECAR;  Q3Z7F2, HIS5_DEHM1;  Q3ZY50, HIS5_DEHMC;  
Q9RX89, HIS5_DEIRA;  C6C1X6, HIS5_DESAD;  Q316L3, HIS5_DESAG;  
B8J215, HIS5_DESDA;  B8FP22, HIS5_DESHD;  Q24QJ3, HIS5_DESHY;  
P61779, HIS5_DESVH;  B8DQX7, HIS5_DESVM;  A1VGZ0, HIS5_DESVV;  
P58237, HIS5_ECO57;  P60596, HIS5_ECOL6;  P60595, HIS5_ECOLI;  
Q9P4P9, HIS5_EMENI;  B1YL11, HIS5_EXIS2;  Q5KVC8, HIS5_GEOKA;  
Q39YP4, HIS5_GEOMG;  P60599, HIS5_GEOSL;  C5D7P0, HIS5_GEOSW;  
A4ISR4, HIS5_GEOTN;  B7KGN3, HIS5_GLOC7;  Q7NNK4, HIS5_GLOVI;  
Q5FTN5, HIS5_GLUOX;  Q0BPX1, HIS5_GRABC;  Q4QN71, HIS5_HAEI8;  
P44340, HIS5_HAEIN;  Q5UYV3, HIS5_HALMA;  Q9HNI6, HIS5_HALSA;  
Q7VIW9, HIS5_HELHP;  A9B5I2, HIS5_HERA2;  Q31E66, HIS5_HYDCU;  
Q5QWQ7, HIS5_IDILO;  B3WED3, HIS5_LACCB;  Q02132, HIS5_LACLA;  
Q039B3, HIS5_LACP3;  Q88UE1, HIS5_LACPL;  Q9RDX3, HIS5_LEGPN;  
Q6AE14, HIS5_LEIXX;  Q9ZGM1, HIS5_LEPBO;  P61780, HIS5_LEPIC;  
P59118, HIS5_LEPIN;  Q9S4H8, HIS5_LEPIR;  Q92E86, HIS5_LISIN;  
C1L0J4, HIS5_LISMC;  Q722Y5, HIS5_LISMF;  B8DA60, HIS5_LISMH;  
Q8Y9G3, HIS5_LISMO;  A0AG17, HIS5_LISW6;  Q65RB8, HIS5_MANSM;  
Q8TS91, HIS5_METAC;  Q465U3, HIS5_METBF;  Q603K1, HIS5_METCA;  
Q57929, HIS5_METJA;  Q8TV83, HIS5_METKA;  Q8PVD5, HIS5_METMA;  
O27568, HIS5_METTH;  B0JFQ9, HIS5_MICAN;  Q2RGW0, HIS5_MOOTA;  
P59957, HIS5_MYCBO;  Q9X7C0, HIS5_MYCLE;  P60600, HIS5_MYCPA;  
P9WMM0, HIS5_MYCTO;  P9WMM1, HIS5_MYCTU;  Q3IUP8, HIS5_NATPD;  
Q5FA21, HIS5_NEIG1;  Q9JVH3, HIS5_NEIMA;  Q9K0H2, HIS5_NEIMB;  
Q820D2, HIS5_NITEU;  Q2YAU8, HIS5_NITMU;  Q3J6Q3, HIS5_NITOC;  
Q5YYP7, HIS5_NOCFA;  B2J1A3, HIS5_NOSP7;  Q8YX49, HIS5_NOSS1;  
Q8ESS0, HIS5_OCEIH;  P57921, HIS5_PASMU;  Q6D408, HIS5_PECAS;  
Q3A135, HIS5_PELCD;  Q3B286, HIS5_PELLD;  Q4FNT5, HIS5_PELUB;  
Q7N6I3, HIS5_PHOLL;  P62448, HIS5_PHOPR;  Q6KZD3, HIS5_PICTO;  
A9BB49, HIS5_PROM4;  Q31AG5, HIS5_PROM9;  Q7VBF5, HIS5_PROMA;  
Q7V127, HIS5_PROMP;  Q46JZ5, HIS5_PROMT;  Q48C78, HIS5_PSE14;  
Q4KJS7, HIS5_PSEF5;  Q3KJI8, HIS5_PSEPF;  Q88R44, HIS5_PSEPK;  
Q87UG1, HIS5_PSESM;  Q4ZLP9, HIS5_PSEU2;  Q4FPU1, HIS5_PSYA2;  
Q8ZY40, HIS5_PYRAE;  P58789, HIS5_PYRFU;  Q8XV83, HIS5_RALSO;  
A9WQ58, HIS5_RENSM;  Q98CT5, HIS5_RHILO;  Q92TB1, HIS5_RHIME;  
Q7ULP3, HIS5_RHOBA;  P60601, HIS5_RHOPA;  Q2RNA5, HIS5_RHORT;  
O33565, HIS5_RHOS4;  Q5LU93, HIS5_RUEPO;  O33777, HIS5_SACS2;  
Q57MS0, HIS5_SALCH;  Q5PDP6, HIS5_SALPA;  Q2S299, HIS5_SALRD;  
P0A1R5, HIS5_SALTI;  P0A1R4, HIS5_SALTY;  O94303, HIS5_SCHPO;  
A3QF19, HIS5_SHELP;  Q8EFB4, HIS5_SHEON;  A8FWC9, HIS5_SHESH;  
Q323I9, HIS5_SHIBS;  Q32EF2, HIS5_SHIDS;  Q83KJ5, HIS5_SHIFL;  
Q3Z0G2, HIS5_SHISS;  Q2YZ69, HIS5_STAAB;  Q5HCM2, HIS5_STAAC;  
P64363, HIS5_STAAM;  P64364, HIS5_STAAN;  Q6GDC9, HIS5_STAAR;  
Q6G600, HIS5_STAAS;  P64365, HIS5_STAAW;  Q5HKP0, HIS5_STAEQ;  
Q8CTV0, HIS5_STAES;  Q4A047, HIS5_STAS1;  Q82AA2, HIS5_STRAW;  
P16249, HIS5_STRCO;  A8AY26, HIS5_STRGC;  Q8DTR1, HIS5_STRMU;  
A3CNT2, HIS5_STRSV;  Q4J8I5, HIS5_SULAC;  Q30PY0, HIS5_SULDN;  
Q970Y7, HIS5_SULTO;  Q67KH8, HIS5_SYMTH;  Q31N58, HIS5_SYNE7;  
Q2JVR1, HIS5_SYNJA;  Q2JN09, HIS5_SYNJB;  Q5MZ63, HIS5_SYNP6;  
Q3AYZ0, HIS5_SYNS9;  Q3AI95, HIS5_SYNSC;  Q55805, HIS5_SYNY3;  
Q8DIP5, HIS5_THEEB;  Q47QS5, HIS5_THEFY;  Q5JFV0, HIS5_THEKO;  
Q9X0C8, HIS5_THEMA;  P61781, HIS5_THET2;  Q7SIC0, HIS5_THET8;  
Q3SEU6, HIS5_THIDA;  Q113E7, HIS5_TRIEI;  Q3M5W4, HIS5_TRIV2;  
Q9KSX0, HIS5_VIBCH;  Q87QK8, HIS5_VIBPA;  Q8D8Q3, HIS5_VIBVU;  
Q7M9X0, HIS5_WOLSU;  Q8PLG8, HIS5_XANAC;  Q3BUF4, HIS5_XANC5;  
Q4UU43, HIS5_XANC8;  Q8P9P1, HIS5_XANCP;  Q2P3K0, HIS5_XANOM;  
Q5H0K8, HIS5_XANOR;  Q9PBC8, HIS5_XYLFA;  Q87C32, HIS5_XYLFT;  
P33734, HIS5_YEAST;  Q8ZFX8, HIS5_YERPE;  Q66C52, HIS5_YERPS;  
Q5NMD4, HIS5_ZYMMO;  Q9PM72, HIS61_CAMJE;  Q7V8Q8, HIS61_PROMM;  
Q9HU44, HIS61_PSEAE;  Q7U5M8, HIS61_SYNPX;  Q7MLS1, HIS61_VIBVY;  
Q0P8U3, HIS62_CAMJE;  A1W0U8, HIS62_CAMJJ;  Q7V958, HIS62_PROMM;  
P72139, HIS62_PSEAE;  Q7U923, HIS62_SYNPX;  Q7MPP3, HIS62_VIBVY;  
Q7MPK7, HIS63_VIBVY;  A1TL06, HIS6_ACIAC;  Q6F799, HIS6_ACIAD;  
B7GVJ5, HIS6_ACIB3;  B7IBD7, HIS6_ACIB5;  B2I0P3, HIS6_ACIBC;  
A3M9P1, HIS6_ACIBT;  C1FAD8, HIS6_ACIC5;  A5FYE5, HIS6_ACICJ;  
B9MDW3, HIS6_ACIET;  B7JA19, HIS6_ACIF2;  B5EQF2, HIS6_ACIF5;  
A1W444, HIS6_ACISJ;  B3GZH3, HIS6_ACTP7;  A6VQ74, HIS6_ACTSZ;  
A0KKB0, HIS6_AERHH;  A4SMQ4, HIS6_AERS4;  P58799, HIS6_AGRFC;  
B2UQA2, HIS6_AKKM8;  Q0VM72, HIS6_ALCBS;  Q5E633, HIS6_ALIF1;  
B5FDA4, HIS6_ALIFM;  B6EJ93, HIS6_ALISL;  Q0A5D3, HIS6_ALKEH;  
A6TKT6, HIS6_ALKMQ;  B4RU62, HIS6_ALTMD;  B7GL45, HIS6_ANOFW;  
O66567, HIS6_AQUAE;  A8EQW5, HIS6_ARCB4;  O29439, HIS6_ARCFU;  
Q5P795, HIS6_AROAE;  A0JVK5, HIS6_ARTS2;  P26721, HIS6_AZOBR;  
A8HYT7, HIS6_AZOC5;  B6YQ30, HIS6_AZOPC;  A1KAV4, HIS6_AZOSB;  
C1DJD3, HIS6_AZOVD;  C3P506, HIS6_BACAA;  C3L9P7, HIS6_BACAC;  
A0RBM2, HIS6_BACAH;  Q81T58, HIS6_BACAN;  B7JFZ5, HIS6_BACC0;  
P62449, HIS6_BACC1;  B7INA3, HIS6_BACC2;  C1EMQ7, HIS6_BACC3;  
B7HHG5, HIS6_BACC4;  B7HKD4, HIS6_BACC7;  A7GMV0, HIS6_BACCN;  
B9IV00, HIS6_BACCQ;  Q81G02, HIS6_BACCR;  Q63DW8, HIS6_BACCZ;  
Q5LBD7, HIS6_BACFN;  Q64RT2, HIS6_BACFR;  Q9K6Z6, HIS6_BACHD;  
Q6HLE3, HIS6_BACHK;  Q65EG3, HIS6_BACLD;  A9VLH7, HIS6_BACMK;  
A8FHQ9, HIS6_BACP2;  Q5WDI2, HIS6_BACSK;  O34727, HIS6_BACSU;  
Q8A7Z6, HIS6_BACTN;  A6L6Z2, HIS6_BACV8;  A7Z962, HIS6_BACVZ;  
Q1LT72, HIS6_BAUCH;  B2ICL0, HIS6_BEII9;  C5BV99, HIS6_BEUC1;  
B8DUB2, HIS6_BIFA0;  A1A1I5, HIS6_BIFAA;  B3DRT8, HIS6_BIFLD;  
Q8G6F7, HIS6_BIFLO;  B7GQS5, HIS6_BIFLS;  Q7VQW5, HIS6_BLOFL;  
Q494D6, HIS6_BLOPB;  Q2KTT1, HIS6_BORA1;  Q7WDX9, HIS6_BORBR;  
Q7W2X9, HIS6_BORPA;  Q7VSY6, HIS6_BORPE;  Q89WM4, HIS6_BRADU;  
A5E8E5, HIS6_BRASB;  A4YJV5, HIS6_BRASO;  C0Z6P4, HIS6_BREBN;  
B2S984, HIS6_BRUA1;  Q2YQY8, HIS6_BRUA2;  Q57AH3, HIS6_BRUAB;  
A9M9R9, HIS6_BRUC2;  C0RFX3, HIS6_BRUMB;  Q8YE37, HIS6_BRUME;  
A5VT43, HIS6_BRUO2;  B0CJI6, HIS6_BRUSI;  Q8FY07, HIS6_BRUSU;  
P57206, HIS6_BUCAI;  Q9ZHE1, HIS6_BUCAP;  P59521, HIS6_BUCBP;  
B1YRW1, HIS6_BURA4;  Q1BS31, HIS6_BURCA;  B1JUA5, HIS6_BURCC;  
A0K3V8, HIS6_BURCH;  B4E641, HIS6_BURCJ;  Q0BIW4, HIS6_BURCM;  
Q39K85, HIS6_BURL3;  Q845U7, HIS6_BURM1;  A3MPU4, HIS6_BURM7;  
A2S754, HIS6_BURM9;  Q62GE5, HIS6_BURMA;  A1V8H5, HIS6_BURMS;  
A3P027, HIS6_BURP0;  Q3JN02, HIS6_BURP1;  A3NE93, HIS6_BURP6;  
Q63Q92, HIS6_BURPS;  Q2SUA8, HIS6_BURTA;  A4JAW9, HIS6_BURVG;  
Q8R885, HIS6_CALS4;  A7ZGB2, HIS6_CAMC1;  A7GVW5, HIS6_CAMC5;  
A0RRT8, HIS6_CAMFF;  A7I416, HIS6_CAMHC;  A8FNR4, HIS6_CAMJ8;  
A7H5V4, HIS6_CAMJD;  Q5HSI8, HIS6_CAMJR;  B9KEI4, HIS6_CAMLR;  
Q3AD48, HIS6_CARHZ;  B0T798, HIS6_CAUSK;  Q9A229, HIS6_CAUVC;  
B8GW15, HIS6_CAUVN;  B3PGA4, HIS6_CELJU;  Q11CK7, HIS6_CHESB;  
A9WD80, HIS6_CHLAA;  B8GBF3, HIS6_CHLAD;  Q3ATG0, HIS6_CHLCH;  
B3EEF2, HIS6_CHLL2;  B3QQ00, HIS6_CHLP8;  B3EKW7, HIS6_CHLPB;  
A1BHP6, HIS6_CHLPD;  A4SFU1, HIS6_CHLPM;  B9LFN2, HIS6_CHLSY;  
B3QSI0, HIS6_CHLT3;  Q8KCB0, HIS6_CHLTE;  Q1R080, HIS6_CHRSD;  
Q7P0E9, HIS6_CHRVO;  A8AEJ9, HIS6_CITK8;  A5CRW2, HIS6_CLAM3;  
Q97KH8, HIS6_CLOAB;  A7FU82, HIS6_CLOB1;  C3KVX6, HIS6_CLOB6;  
A6LT22, HIS6_CLOB8;  B2UX20, HIS6_CLOBA;  A5I246, HIS6_CLOBH;  
C1FN42, HIS6_CLOBJ;  B1ILB0, HIS6_CLOBK;  A7GDQ7, HIS6_CLOBL;  
Q47XB3, HIS6_COLP3;  C3PHA6, HIS6_CORA7;  P60714, HIS6_CORDI;  
Q8FNZ9, HIS6_COREF;  A4QFF9, HIS6_CORGB;  O31139, HIS6_CORGL;  
Q4JW52, HIS6_CORJK;  B1VH88, HIS6_CORU7;  A7MHE1, HIS6_CROS8;  
Q1LIB2, HIS6_CUPMC;  Q0K693, HIS6_CUPNH;  Q46WL8, HIS6_CUPPJ;  
B3R794, HIS6_CUPTR;  Q6A7Y8, HIS6_CUTAK;  Q11VM1, HIS6_CYTH3;  
Q47AM3, HIS6_DECAR;  Q3Z7F5, HIS6_DEHM1;  A5FQI9, HIS6_DEHMB;  
Q3ZY29, HIS6_DEHMC;  Q1IX39, HIS6_DEIGD;  Q9RWD7, HIS6_DEIRA;  
A9BXA1, HIS6_DELAS;  Q316L4, HIS6_DESAG;  C0Q9D3, HIS6_DESAH;  
B8FFL4, HIS6_DESAL;  B1I556, HIS6_DESAP;  B8J216, HIS6_DESDA;  
B8FP24, HIS6_DESHD;  Q24QJ5, HIS6_DESHY;  C4XS73, HIS6_DESMR;  
A8ZVD2, HIS6_DESOH;  A4J707, HIS6_DESRM;  P62450, HIS6_DESVH;  
B8DQX6, HIS6_DESVM;  A1VGY9, HIS6_DESVV;  B5YE90, HIS6_DICT6;  
B8E2C8, HIS6_DICTD;  A8LHX5, HIS6_DINSH;  A7ZNJ7, HIS6_ECO24;  
B7UT62, HIS6_ECO27;  B7MDH9, HIS6_ECO45;  B7L9Q2, HIS6_ECO55;  
P60665, HIS6_ECO57;  B5YU81, HIS6_ECO5E;  B7NQG5, HIS6_ECO7I;  
B7MWU3, HIS6_ECO81;  B7M404, HIS6_ECO8A;  C4ZSB4, HIS6_ECOBW;  
B1X6W2, HIS6_ECODH;  A8A1P9, HIS6_ECOHS;  A1ACN7, HIS6_ECOK1;  
Q0TG62, HIS6_ECOL5;  Q8FG48, HIS6_ECOL6;  B1IZ49, HIS6_ECOLC;  
P60664, HIS6_ECOLI;  B7NC65, HIS6_ECOLU;  B6I896, HIS6_ECOSE;  
B1LP16, HIS6_ECOSM;  Q1RA48, HIS6_ECOUT;  C5BG16, HIS6_EDWI9;  
B2KEU8, HIS6_ELUMP;  A4WC74, HIS6_ENT38;  B7LUF6, HIS6_ESCF3;  
B1YL09, HIS6_EXIS2;  C4L176, HIS6_EXISA;  A5FFX6, HIS6_FLAJ1;  
A6GY75, HIS6_FLAPJ;  Q2J8L3, HIS6_FRACC;  B0TY41, HIS6_FRAP2;  
B5EDR4, HIS6_GEOBB;  B9M0M0, HIS6_GEODF;  Q5KVD0, HIS6_GEOKA;  
B3E617, HIS6_GEOLS;  Q39YP2, HIS6_GEOMG;  P60715, HIS6_GEOSL;  
C6E7F4, HIS6_GEOSM;  C5D7N8, HIS6_GEOSW;  A4ISR2, HIS6_GEOTN;  
A5G8S9, HIS6_GEOUR;  Q7NDC1, HIS6_GLOVI;  A9GZW9, HIS6_GLUDA;  
Q5FTN3, HIS6_GLUOX;  A0M283, HIS6_GRAFK;  Q4QN69, HIS6_HAEI8;  
A5UA15, HIS6_HAEIE;  P44436, HIS6_HAEIN;  Q2SMB2, HIS6_HAHCH;  
A1WW05, HIS6_HALHL;  Q5V2C9, HIS6_HALMA;  B8D116, HIS6_HALOH;  
B0R4B2, HIS6_HALS3;  Q9HR52, HIS6_HALSA;  Q18JI3, HIS6_HALWD;  
Q7VGZ1, HIS6_HELHP;  B0TDM7, HIS6_HELMI;  Q8GDQ6, HIS6_HELMO;  
A9B5I5, HIS6_HERA2;  A4G9I6, HIS6_HERAR;  A3DJF7, HIS6_HUNT2;  
Q31E64, HIS6_HYDCU;  B4U7M4, HIS6_HYDS0;  Q0C643, HIS6_HYPNA;  
Q5QWQ5, HIS6_IDILO;  A8AAK3, HIS6_IGNH4;  A6T376, HIS6_JANMA;  
Q28NK0, HIS6_JANSC;  A6WC96, HIS6_KINRD;  P45603, HIS6_KLEOX;  
B5XPE2, HIS6_KLEP3;  A6TBC8, HIS6_KLEP7;  B2GGU9, HIS6_KOCRD;  
Q1IKB2, HIS6_KORVE;  B3WED1, HIS6_LACCB;  B2GBR5, HIS6_LACF3;  
Q02133, HIS6_LACLA;  A2RKR7, HIS6_LACLM;  Q02YX1, HIS6_LACLS;  
Q039B5, HIS6_LACP3;  A9KP30, HIS6_LACP7;  Q88UE3, HIS6_LACPL;  
C1DAK5, HIS6_LARHH;  Q9RDX2, HIS6_LEGPN;  Q6AF73, HIS6_LEIXX;  
B0S8V2, HIS6_LEPBA;  Q04SA6, HIS6_LEPBJ;  Q050D2, HIS6_LEPBL;  
Q9ZGM0, HIS6_LEPBO;  B0SRP0, HIS6_LEPBP;  P62451, HIS6_LEPIC;  
P59119, HIS6_LEPIN;  Q9S4H7, HIS6_LEPIR;  Q03VY0, HIS6_LEUMM;  
Q92E88, HIS6_LISIN;  C1L0J2, HIS6_LISMC;  Q722Y7, HIS6_LISMF;  
B8DA62, HIS6_LISMH;  Q8Y9G5, HIS6_LISMO;  A0AG15, HIS6_LISW6;  
B1HVQ1, HIS6_LYSSC;  A0LCF3, HIS6_MAGMM;  Q2VYJ0, HIS6_MAGSA;  
Q65RC1, HIS6_MANSM;  A1U5H5, HIS6_MARHV;  Q0AP84, HIS6_MARMM;  
A6VTA6, HIS6_MARMS;  A6UUZ9, HIS6_META3;  Q8TT96, HIS6_METAC;  
Q0W358, HIS6_METAR;  A7I616, HIS6_METB6;  Q46CC5, HIS6_METBF;  
Q12UY6, HIS6_METBU;  B7KPM8, HIS6_METC4;  Q603K3, HIS6_METCA;  
A9W5U0, HIS6_METEP;  Q1H4R2, HIS6_METFK;  Q2FPV1, HIS6_METHJ;  
Q57854, HIS6_METJA;  Q8TYW8, HIS6_METKA;  A2STB8, HIS6_METLZ;  
A4G0J7, HIS6_METM5;  A9A8U1, HIS6_METM6;  A6VHY8, HIS6_METM7;  
Q8PW92, HIS6_METMA;  A3CT78, HIS6_METMJ;  P62454, HIS6_METMP;  
B8IPH3, HIS6_METNO;  B1ZAD6, HIS6_METPB;  B8GEX3, HIS6_METPE;  
A2SE09, HIS6_METPP;  B1LUA2, HIS6_METRJ;  A5UMZ1, HIS6_METS3;  
B0UHR5, HIS6_METS4;  A4YI34, HIS6_METS5;  B8EM84, HIS6_METSB;  
Q2NI84, HIS6_METST;  O27398, HIS6_METTH;  A6UR05, HIS6_METVS;  
B0JY78, HIS6_MICAN;  C5CBK1, HIS6_MICLC;  Q2RGW2, HIS6_MOOTA;  
A0QHH6, HIS6_MYCA1;  B1MBX3, HIS6_MYCA9;  Q7VEW8, HIS6_MYCBO;  
A1KJ21, HIS6_MYCBP;  C1ANM7, HIS6_MYCBT;  A4T9N2, HIS6_MYCGI;  
B8ZRB4, HIS6_MYCLB;  Q9X7C2, HIS6_MYCLE;  B2HQA8, HIS6_MYCMM;  
P60666, HIS6_MYCPA;  A0QX87, HIS6_MYCS2;  A3Q125, HIS6_MYCSJ;  
A1UHK2, HIS6_MYCSK;  Q1B7H0, HIS6_MYCSS;  A5U2W1, HIS6_MYCTA;  
P9WMM2, HIS6_MYCTO;  P9WMM3, HIS6_MYCTU;  A0PP20, HIS6_MYCUA;  
A1T8W7, HIS6_MYCVP;  Q1D4M4, HIS6_MYXXD;  Q3INY2, HIS6_NATPD;  
B2A6X0, HIS6_NATTJ;  B9L718, HIS6_NAUPA;  Q5FA23, HIS6_NEIG1;  
B4RJN3, HIS6_NEIG2;  A9M2Q5, HIS6_NEIM0;  Q9JVH5, HIS6_NEIMA;  
Q9K0H4, HIS6_NEIMB;  A1KSN6, HIS6_NEIMF;  Q0AEU1, HIS6_NITEC;  
Q820Q0, HIS6_NITEU;  Q1QRX0, HIS6_NITHX;  A9A5X0, HIS6_NITMS;  
Q2YAV0, HIS6_NITMU;  Q3J6Q1, HIS6_NITOC;  A6Q117, HIS6_NITSB;  
Q3SWF1, HIS6_NITWN;  Q5YYP3, HIS6_NOCFA;  A1SL56, HIS6_NOCSJ;  
Q8YT31, HIS6_NOSS1;  Q8ESS2, HIS6_OCEIH;  A6WX52, HIS6_OCHA4;  
B6JCG5, HIS6_OLICO;  B1ZX57, HIS6_OPITP;  A1R5S1, HIS6_PAEAT;  
A6LDI7, HIS6_PARD8;  A1B388, HIS6_PARDP;  A7HSH0, HIS6_PARL1;  
B2JHX9, HIS6_PARP8;  B2SZ59, HIS6_PARPJ;  Q13TR0, HIS6_PARXL;  
Q9CLM0, HIS6_PASMU;  Q6D406, HIS6_PECAS;  C6DF71, HIS6_PECCP;  
Q3A137, HIS6_PELCD;  Q3B2Q6, HIS6_PELLD;  B4SFM7, HIS6_PELPB;  
A5CZ73, HIS6_PELTS;  Q4FNT7, HIS6_PELUB;  Q18C74, HIS6_PEPD6;  
C0QPQ6, HIS6_PERMH;  A9BJZ9, HIS6_PETMO;  Q7N6I5, HIS6_PHOLL;  
P62452, HIS6_PHOPR;  A4SV20, HIS6_POLAQ;  A1VK42, HIS6_POLNA;  
B1XSV3, HIS6_POLNS;  Q12FC7, HIS6_POLSJ;  B4S9G0, HIS6_PROA2;  
A3PBF2, HIS6_PROM0;  A2C0N7, HIS6_PROM1;  A8G3E4, HIS6_PROM2;  
A9BE47, HIS6_PROM4;  A2BV90, HIS6_PROM5;  Q31CA5, HIS6_PROM9;  
Q7VDF1, HIS6_PROMA;  B4ESZ8, HIS6_PROMH;  Q7V2P2, HIS6_PROMP;  
A2BPR2, HIS6_PROMS;  Q46GY9, HIS6_PROMT;  Q48C81, HIS6_PSE14;  
Q15RU3, HIS6_PSEA6;  A6VDQ9, HIS6_PSEA7;  B7V3N3, HIS6_PSEA8;  
Q02EM6, HIS6_PSEAB;  B8H6U2, HIS6_PSECP;  Q1I3G8, HIS6_PSEE4;  
Q4KJS4, HIS6_PSEF5;  C3K6V3, HIS6_PSEFS;  Q3ICD4, HIS6_PSEHT;  
A4Y083, HIS6_PSEMY;  A5VX76, HIS6_PSEP1;  Q3KJI5, HIS6_PSEPF;  
B0KI45, HIS6_PSEPG;  Q88R41, HIS6_PSEPK;  B1JED1, HIS6_PSEPW;  
Q87UG4, HIS6_PSESM;  Q4ZLQ2, HIS6_PSEU2;  A4VRV9, HIS6_PSEU5;  
Q4FPZ3, HIS6_PSYA2;  Q1Q835, HIS6_PSYCK;  A1SVC5, HIS6_PSYIN;  
A5WHT5, HIS6_PSYWF;  Q8ZY16, HIS6_PYRAE;  P58800, HIS6_PYRFU;  
B2UEE5, HIS6_RALPJ;  Q8XV85, HIS6_RALSO;  A9WR62, HIS6_RENSM;  
Q98CT1, HIS6_RHILO;  Q92TB3, HIS6_RHIME;  Q7UKJ9, HIS6_RHOBA;  
O30724, HIS6_RHOCB;  B6IWI7, HIS6_RHOCS;  C1A0L6, HIS6_RHOE4;  
Q21U91, HIS6_RHOFT;  Q0SHY7, HIS6_RHOJR;  C1ATY7, HIS6_RHOOB;  
Q2J340, HIS6_RHOP2;  Q07UQ9, HIS6_RHOP5;  P60667, HIS6_RHOPA;  
Q21CK1, HIS6_RHOPB;  Q13E40, HIS6_RHOPS;  B3Q951, HIS6_RHOPT;  
Q2RNA7, HIS6_RHORT;  A3PI62, HIS6_RHOS1;  P50937, HIS6_RHOS4;  
A4WUS8, HIS6_RHOS5;  B9KPC8, HIS6_RHOSK;  Q162Q1, HIS6_ROSDO;  
A5UY52, HIS6_ROSS1;  Q5LU99, HIS6_RUEPO;  Q1GEZ3, HIS6_RUEST;  
B8I5V6, HIS6_RUMCH;  A1AV74, HIS6_RUTMC;  Q21NH5, HIS6_SACD2;  
O33774, HIS6_SACS2;  B5EX44, HIS6_SALA4;  A8LX55, HIS6_SALAI;  
A9ML11, HIS6_SALAR;  Q57MR8, HIS6_SALCH;  B5FM46, HIS6_SALDC;  
B5QZL7, HIS6_SALEP;  B5RBR7, HIS6_SALG2;  B4T9N9, HIS6_SALHS;  
B4SX46, HIS6_SALNS;  Q5PDN6, HIS6_SALPA;  A9N7S0, HIS6_SALPB;  
C0Q1J7, HIS6_SALPC;  B5BFB5, HIS6_SALPK;  Q2S295, HIS6_SALRD;  
B4TMS0, HIS6_SALSV;  P0A1R3, HIS6_SALTI;  A4X9P7, HIS6_SALTO;  
P0A1R2, HIS6_SALTY;  A8GC74, HIS6_SERP5;  A1S6Z6, HIS6_SHEAM;  
B8E999, HIS6_SHEB2;  A3D5B1, HIS6_SHEB5;  A6WP22, HIS6_SHEB8;  
A9L4C0, HIS6_SHEB9;  Q12NT0, HIS6_SHEDO;  Q083K1, HIS6_SHEFN;  
B0TQY8, HIS6_SHEHH;  A3QF21, HIS6_SHELP;  Q8CX42, HIS6_SHEON;  
A8H5E5, HIS6_SHEPA;  A4Y7H2, HIS6_SHEPC;  B8CR54, HIS6_SHEPW;  
A0KWB0, HIS6_SHESA;  A8FWD1, HIS6_SHESH;  Q0HJ99, HIS6_SHESM;  
Q0HUN4, HIS6_SHESR;  A1RJ16, HIS6_SHESW;  B1KRF9, HIS6_SHEWM;  
B2TYF5, HIS6_SHIB3;  Q323I7, HIS6_SHIBS;  Q32EF4, HIS6_SHIDS;  
Q0T3A2, HIS6_SHIF8;  Q83R03, HIS6_SHIFL;  Q3Z0G0, HIS6_SHISS;  
C3MBC1, HIS6_SINFN;  A6UEK3, HIS6_SINMW;  Q2NTX6, HIS6_SODGM;  
Q01ZU6, HIS6_SOLUE;  A9GBI6, HIS6_SORC5;  Q1GNC3, HIS6_SPHAL;  
A5V9W0, HIS6_SPHWW;  A7X763, HIS6_STAA1;  A6U558, HIS6_STAA2;  
Q2FDI8, HIS6_STAA3;  A5IWA0, HIS6_STAA9;  Q2YZ71, HIS6_STAAB;  
Q5HCM4, HIS6_STAAC;  A6QKG1, HIS6_STAAE;  P64361, HIS6_STAAM;  
P64362, HIS6_STAAN;  Q6GDD1, HIS6_STAAR;  Q6G602, HIS6_STAAS;  
A8Z5H3, HIS6_STAAT;  Q8NUI3, HIS6_STAAW;  B9DIP1, HIS6_STACT;  
Q5HKP2, HIS6_STAEQ;  Q8CQ92, HIS6_STAES;  Q4A049, HIS6_STAS1;  
Q82A99, HIS6_STRAW;  Q9S2T7, HIS6_STRCO;  A8AY24, HIS6_STRGC;  
B1W0M6, HIS6_STRGG;  B4STP2, HIS6_STRM5;  B2FPM4, HIS6_STRMK;  
Q8DTR3, HIS6_STRMU;  A3CNT0, HIS6_STRSV;  Q4J8I9, HIS6_SULAC;  
Q30NR6, HIS6_SULDN;  A6QCU4, HIS6_SULNB;  B2V9M8, HIS6_SULSY;  
Q970Z0, HIS6_SULTO;  Q67KI0, HIS6_SYMTH;  A0LFI1, HIS6_SYNFM;  
Q5N0H4, HIS6_SYNP6;  Q0ICA6, HIS6_SYNS3;  Q3AWY4, HIS6_SYNS9;  
Q3ALF6, HIS6_SYNSC;  Q0AW41, HIS6_SYNWW;  P74106, HIS6_SYNY3;  
C5BMF5, HIS6_TERTT;  Q8DJN7, HIS6_THEEB;  Q47QS3, HIS6_THEFY;  
C5A7A2, HIS6_THEGJ;  Q5JFU8, HIS6_THEKO;  Q9X0C6, HIS6_THEMA;  
B6YWA9, HIS6_THEON;  A5INE6, HIS6_THEP1;  Q9RPQ4, HIS6_THEP3;  
B0K629, HIS6_THEPX;  B9KXJ6, HIS6_THERP;  B1L873, HIS6_THESQ;  
P62453, HIS6_THET2;  Q7SIB9, HIS6_THET8;  B5YIB7, HIS6_THEYD;  
Q3SEU8, HIS6_THIDA;  B8GU32, HIS6_THISH;  C4LFI4, HIS6_TOLAT;  
Q3MEF5, HIS6_TRIV2;  B1H0E6, HIS6_UNCTG;  C5CQK0, HIS6_VARPS;  
A1WR24, HIS6_VEREI;  A5CXY8, HIS6_VESOH;  A5F289, HIS6_VIBC3;  
A7MX10, HIS6_VIBCB;  Q9KSW8, HIS6_VIBCH;  C3LLI5, HIS6_VIBCM;  
Q87QK6, HIS6_VIBPA;  B7VGZ7, HIS6_VIBTL;  Q8D8Q5, HIS6_VIBVU;  
Q7MAS1, HIS6_WOLSU;  Q8PLG6, HIS6_XANAC;  Q3BUF2, HIS6_XANC5;  
Q4UU45, HIS6_XANC8;  B0RSL9, HIS6_XANCB;  Q8P9N9, HIS6_XANCP;  
Q2P3J8, HIS6_XANOM;  Q5H0K6, HIS6_XANOR;  A7IHN9, HIS6_XANP2;  
B2I5X6, HIS6_XYLF2;  Q9PBD0, HIS6_XYLFA;  B0U3A8, HIS6_XYLFM;  
Q87C34, HIS6_XYLFT;  A1JTW3, HIS6_YERE8;  A7FJH5, HIS6_YERP3;  
Q1C9R6, HIS6_YERPA;  B2JZM4, HIS6_YERPB;  Q8ZFY0, HIS6_YERPE;  
Q1CGW5, HIS6_YERPN;  A4TKK8, HIS6_YERPP;  Q66C54, HIS6_YERPS;  
B1JPW5, HIS6_YERPY;  Q5NMD6, HIS6_ZYMMO;  

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