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ENZYME

ENZYME entry: EC 4.3.2.7

PURL: https://purl.expasy.org/enzyme/EC/4.3.2.7
Accepted Name
glutathione-specific gamma-glutamylcyclotransferase
Alternative Name(s)
gamma-glu-GCG
Reaction catalysed
glutathione = L-cysteinylglycine + 5-oxo-L-proline
Comment(s)
  • The enzyme, found in bacteria, fungi and animals, is specific for glutathione (cf. EC 4.3.2.9).
  • The enzyme acts as a cyclotransferase, cleaving the amide bond via transamidation using the alpha-amine of the L-glutamyl residue, releasing it as the cyclic 5-oxo-L-proline.
Cross-references
BRENDA4.3.2.7
EC2PDB4.3.2.7
ExplorEnz4.3.2.7
KEGG Ligand Database for Enzyme Nomenclature4.3.2.7
IUBMB Enzyme Nomenclature4.3.2.7
MEDLINEFind literature relating to 4.3.2.7
MetaCyc4.3.2.7
Rhea expert-curated reactions4.3.2.7
UniProtKB/Swiss-Prot
Q5SPB6, CHAC1_DANREQ9BUX1, CHAC1_HUMANQ8R3J5, CHAC1_MOUSE
B3STU3, CHAC1_RATQ0IIH4, CHAC2_BOVINQ5ZI66, CHAC2_CHICK
Q4KMJ1, CHAC2_DANREQ8WUX2, CHAC2_HUMANQ9CQG1, CHAC2_MOUSE
Q641Z5, CHAC2_RATQ5PPV4, CHAC2_XENLAP39163, CHAC_ECOLI
P87305, CHAC_SCHPOP32656, CHAC_YEASTQ84MC1, GCT22_ARATH
Q84QC1, GCT23_ARATH

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All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 4.3.2.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 4.3.-.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 4.-.-.-