Home  |  Contact

ENZYME entry: EC 4.3.2.7

Accepted Name
Glutathione-specific gamma-glutamylcyclotransferase.
Alternative Name(s)
Gamma-glu-GCG.
Reaction catalysed
Glutathione <=> L-cysteinylglycine + 5-oxo-L-proline
Comment(s)
  • The enzyme, found in bacteria, fungi and animals, is specific for glutathione (cf. EC 4.3.2.9).
  • The enzyme acts as a cyclotransferase, cleaving the amide bond via transamidation using the alpha-amine of the L-glutamyl residue, releasing it as the cyclic 5-oxo-L-proline.
Cross-references
BRENDA4.3.2.7
EC2PDB4.3.2.7
ExplorEnz4.3.2.7
PRIAM enzyme-specific profiles4.3.2.7
KEGG Ligand Database for Enzyme Nomenclature4.3.2.7
IUBMB Enzyme Nomenclature4.3.2.7
IntEnz4.3.2.7
MEDLINEFind literature relating to 4.3.2.7
MetaCyc4.3.2.7
UniProtKB/Swiss-Prot
Q5SPB6, CHAC1_DANRE;  Q9BUX1, CHAC1_HUMAN;  Q8R3J5, CHAC1_MOUSE;  
B3STU3, CHAC1_RAT;  Q0IIH4, CHAC2_BOVIN;  Q5ZI66, CHAC2_CHICK;  
Q4KMJ1, CHAC2_DANRE;  Q8WUX2, CHAC2_HUMAN;  Q9CQG1, CHAC2_MOUSE;  
Q641Z5, CHAC2_RAT;  Q5PPV4, CHAC2_XENLA;  P39163, CHAC_ECOLI;  
P87305, CHAC_SCHPO;  P32656, CHAC_YEAST;  

View entry in original ENZYME format
View entry in raw text format (no links)
All UniProtKB/Swiss-Prot entries referenced in this entry, with possibility to download in different formats, align etc.
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 4.3.2.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 4.3.-.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 4.-.-.-