ENZYME entry: EC 4.5.1.2
Accepted Name |
3-chloro-D-alanine dehydrochlorinase.
|
Reaction catalysed |
3-chloro-D-alanine + H(2)O <=> pyruvate + chloride + NH(3) |
Cofactor(s) |
Pyridoxal 5'-phosphate.
|
Comment(s) |
- The enzyme cleaves a carbon-chlorine bond, releasing a chloride and
an unstable enamine product that tautomerizes to an imine form, which
undergoes a hydrolytic deamination to form pyruvate and ammonia.
- The latter reaction, which can occur spontaneously, can also be
catalyzed by EC 3.5.99.10.
- The enzyme's activity can also result in beta-replacement reactions,
e.g. in the presence of hydrogen sulfide it can convert 3-chloro-D-
alanine into D-cysteine and chloride.
|
Cross-references |
BRENDA | 4.5.1.2 |
EC2PDB | 4.5.1.2 |
ExplorEnz | 4.5.1.2 |
PRIAM enzyme-specific profiles | 4.5.1.2 |
KEGG Ligand Database for Enzyme Nomenclature | 4.5.1.2 |
IUBMB Enzyme Nomenclature | 4.5.1.2 |
IntEnz | 4.5.1.2 |
MEDLINE | Find literature relating to 4.5.1.2 |
MetaCyc | 4.5.1.2 |
Rhea expert-curated reactions | 4.5.1.2 |
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ENZYME /
UniProtKB/Swiss-Prot entries corresponding to 4.5.1.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 4.5.-.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 4.-.-.-