- The enzyme from mammals accepts a range of hydroperoxy
icosatetraenoates producing one or several different hydroxy epoxy
icosatrienoates.
- The human enzyme has highest activity with (12R)-HPETE producing
(5Z,8R,9E,11R,12R,14Z)-8-hydroxy-11,12-epoxyicosa-5,9,14-trienoate,
followed by (12S)-HPETE producing (5Z,8Z,10R,11S,12S,14Z)-10-hydroxy-
11,12-epoxyicosa-5,8,14-trienoate and (5Z,8R,9E,11S,12S,14Z)-8-
hydroxy-11,12-epoxyicosa-5,9,14-trienoate.
- The mouse enzyme has highest activity with (8S)-HPETE, producing
(5Z,8S,9S,10R,11Z,14Z)-10-hydroxy-8,9-epoxyicosa-5,11,14-trienoate.
- The enzymes also have the activity of EC 4.2.1.152.
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