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ENZYME entry: EC 5.4.4.7

Accepted Name
Hydroperoxy icosatetraenoate isomerase.
Alternative Name(s)
Epidermal lipoxygenase-3.
Reaction catalysed
A hydroperoxy icosatetraenoate <=> a hydroxy epoxy icosatrienoate
Cofactor(s)
Fe(2+).
Comment(s)
  • The enzyme from mammals accepts a range of hydroperoxy icosatetraenoates producing one or several different hydroxy epoxy icosatrienoates.
  • The human enzyme has highest activity with (12R)-HPETE producing (5Z,8R,9E,11R,12R,14Z)-8-hydroxy-11,12-epoxyicosa-5,9,14-trienoate, followed by (12S)-HPETE producing (5Z,8Z,10R,11S,12S,14Z)-10-hydroxy- 11,12-epoxyicosa-5,8,14-trienoate and (5Z,8R,9E,11S,12S,14Z)-8- hydroxy-11,12-epoxyicosa-5,9,14-trienoate.
  • The mouse enzyme has highest activity with (8S)-HPETE, producing (5Z,8S,9S,10R,11Z,14Z)-10-hydroxy-8,9-epoxyicosa-5,11,14-trienoate.
  • The enzymes also have the activity of EC 4.2.1.152.
Cross-references
BRENDA5.4.4.7
EC2PDB5.4.4.7
ExplorEnz5.4.4.7
PRIAM enzyme-specific profiles5.4.4.7
KEGG Ligand Database for Enzyme Nomenclature5.4.4.7
IUBMB Enzyme Nomenclature5.4.4.7
IntEnz5.4.4.7
MEDLINEFind literature relating to 5.4.4.7
MetaCyc5.4.4.7
Rhea expert-curated reactions5.4.4.7
UniProtKB/Swiss-Prot
P51589, CP2J2_HUMAN;  Q9BYJ1, LOXE3_HUMAN;  Q9WV07, LOXE3_MOUSE;  
D3ZKX9, LOXE3_RAT;  

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