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ENZYME entry: EC 4.2.1.152

Accepted Name
Hydroperoxy icosatetraenoate dehydratase.
Alternative Name(s)
Epidermal lipoxygenase-3.
Reaction catalysed
A hydroperoxy icosatetraenoate <=> an oxoicosatetraenoate + H(2)O
Cofactor(s)
Fe(2+).
Comment(s)
  • The mammalian enzymes accept a range of hydroperoxy icosatetraenoates (HPETE).
  • The human enzyme has highest activity with (12R)-HPETE, followed by (12S)-HPETE and (15R)-HPETE with much lower efficiency.
  • The murine enzyme has highest activity with (8R)-HPETE followed by (8S)-HPETE. All HPETE isoforms are converted to the corresponding oxoicosatetraenoate forms (KETE).
  • The enzymes also catalyze the reaction of EC 5.4.4.7.
Cross-references
BRENDA4.2.1.152
EC2PDB4.2.1.152
ExplorEnz4.2.1.152
PRIAM enzyme-specific profiles4.2.1.152
KEGG Ligand Database for Enzyme Nomenclature4.2.1.152
IUBMB Enzyme Nomenclature4.2.1.152
IntEnz4.2.1.152
MEDLINEFind literature relating to 4.2.1.152
MetaCyc4.2.1.152
UniProtKB/Swiss-Prot
Q3LFU0, CP1A1_BALAC;  P56590, CP1A1_CANLF;  Q06367, CP1A1_CAVPO;  
Q5KQT7, CP1A1_FELCA;  P04798, CP1A1_HUMAN;  P33616, CP1A1_MACFA;  
Q6GUR1, CP1A1_MACMU;  Q00557, CP1A1_MESAU;  P00184, CP1A1_MOUSE;  
P05176, CP1A1_RABIT;  P00185, CP1A1_RAT;  P56591, CP1A1_SHEEP;  
Q3LFT9, CP1A2_BALAC;  O77810, CP1A2_CALJA;  P56592, CP1A2_CANLF;  
Q64391, CP1A2_CAVPO;  Q5KQT6, CP1A2_FELCA;  P05177, CP1A2_HUMAN;  
O77809, CP1A2_MACFA;  Q4H4C3, CP1A2_MACFU;  P24453, CP1A2_MESAU;  
P00186, CP1A2_MOUSE;  Q5RBQ1, CP1A2_PONAB;  P00187, CP1A2_RABIT;  
P04799, CP1A2_RAT;  Q16678, CP1B1_HUMAN;  Q64429, CP1B1_MOUSE;  
Q64678, CP1B1_RAT;  Q96SQ9, CP2S1_HUMAN;  Q9DBX6, CP2S1_MOUSE;  
Q9BYJ1, LOXE3_HUMAN;  Q9WV07, LOXE3_MOUSE;  D3ZKX9, LOXE3_RAT;  

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