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ENZYME

ENZYME entry: EC 4.2.1.152

PURL: https://purl.expasy.org/enzyme/EC/4.2.1.152
Accepted Name
hydroperoxy icosatetraenoate dehydratase
Alternative Name(s)
epidermal lipoxygenase-3
Reaction catalysed
a hydroperoxyeicosatetraenoate = an oxoeicosatetraenoate + H2O
Comment(s)
  • The mammalian enzymes accept a range of hydroperoxy icosatetraenoates (HPETE).
  • The human enzyme has highest activity with (12R)-HPETE, followed by (12S)-HPETE and (15R)-HPETE with much lower efficiency.
  • The murine enzyme has highest activity with (8R)-HPETE followed by (8S)-HPETE. All HPETE isoforms are converted to the corresponding oxoicosatetraenoate forms (KETE).
  • The enzymes also catalyze the reaction of EC 5.4.4.7.
Cross-references
BRENDA4.2.1.152
EC2PDB4.2.1.152
ExplorEnz4.2.1.152
KEGG Ligand Database for Enzyme Nomenclature4.2.1.152
IUBMB Enzyme Nomenclature4.2.1.152
MEDLINEFind literature relating to 4.2.1.152
MetaCyc4.2.1.152
Rhea expert-curated reactions4.2.1.152
UniProtKB/Swiss-Prot
Q3LFU0, CP1A1_BALACP56590, CP1A1_CANLFQ06367, CP1A1_CAVPO
Q5KQT7, CP1A1_FELCAP04798, CP1A1_HUMANP33616, CP1A1_MACFA
Q6GUR1, CP1A1_MACMUQ00557, CP1A1_MESAUP00184, CP1A1_MOUSE
P05176, CP1A1_RABITP00185, CP1A1_RATP56591, CP1A1_SHEEP
Q3LFT9, CP1A2_BALACO77810, CP1A2_CALJAP56592, CP1A2_CANLF
Q64391, CP1A2_CAVPOQ5KQT6, CP1A2_FELCAP05177, CP1A2_HUMAN
O77809, CP1A2_MACFAQ4H4C3, CP1A2_MACFUP24453, CP1A2_MESAU
P00186, CP1A2_MOUSEQ5RBQ1, CP1A2_PONABP00187, CP1A2_RABIT
P04799, CP1A2_RATQ16678, CP1B1_HUMANQ64429, CP1B1_MOUSE
Q64678, CP1B1_RATQ96SQ9, CP2S1_HUMANQ9DBX6, CP2S1_MOUSE
Q9BYJ1, LOXE3_HUMANQ9WV07, LOXE3_MOUSED3ZKX9, LOXE3_RAT
Q29626, PTGIS_BOVINF1RE08, PTGIS_DANREQ16647, PTGIS_HUMAN
O35074, PTGIS_MOUSEQ62969, PTGIS_RATQ2KIG5, THAS_BOVIN
P24557, THAS_HUMANQ2PG45, THAS_MACFAP36423, THAS_MOUSE
P47787, THAS_PIGP49430, THAS_RAT

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All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 4.2.1.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 4.2.-.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 4.-.-.-