A new class EC 7, Translocases, has been added to the EC list. It will be part of ENZYME from release 2018_10. Read more about EC 7 here.
The following ENZYME entries belong to class 5.99.-.-:
18.104.22.168 Thiocyanate isomerase 22.214.171.124 DNA topoisomerase 126.96.36.199 DNA topoisomerase (ATP-hydrolyzing) 188.8.131.52 2-hydroxychromene-2-carboxylate isomerase