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ENZYME

ENZYME entry: EC 6.1.1.23

Accepted Name
aspartate--tRNA(Asn) ligase
Alternative Name(s)
nondiscriminating aspartyl-tRNA synthetase
Reaction catalysed
ATP + L-aspartate + tRNA(Asx) <=> AMP + diphosphate + L-aspartyl-tRNA(Asx)
Comment(s)
  • When this enzyme acts on tRNA(Asp), it catalyzes the same reaction as EC 6.1.1.12.
  • It has, however, diminished discrimination, so that it can also form aspartyl-tRNA(Asn).
  • This relaxation of specificity has been found to result from the absence of a loop in the tRNA that specifically recognizes the third position of the anticodon.
  • This accounts for the ability of this enzyme in, for example, Thermus thermophilus, to recognize both tRNA(Asp) (GUC anticodon) and tRNA(Asn) (GUU anticodon).
  • The aspartate-tRNA(Asn) is not used in protein synthesis until it is converted by EC 6.3.5.6 into asparaginyl-tRNA(Asn).
Cross-references
BRENDA6.1.1.23
EC2PDB6.1.1.23
ExplorEnz6.1.1.23
PRIAM enzyme-specific profiles6.1.1.23
KEGG Ligand Database for Enzyme Nomenclature6.1.1.23
IUBMB Enzyme Nomenclature6.1.1.23
IntEnz6.1.1.23
MEDLINEFind literature relating to 6.1.1.23
MetaCyc6.1.1.23
Rhea expert-curated reactions6.1.1.23
UniProtKB/Swiss-Prot
Q2LPW5, SYDN1_SYNASQ2LTE0, SYDN2_SYNASB0CF01, SYDND_ACAM1
A1TT99, SYDND_ACIACQ6FEH6, SYDND_ACIADB7GWN1, SYDND_ACIB3
B7I8M5, SYDND_ACIB5B2HYL7, SYDND_ACIBCB0VRC7, SYDND_ACIBS
A3M8Q6, SYDND_ACIBTB0V550, SYDND_ACIBYA0LUJ6, SYDND_ACIC1
C1FAE8, SYDND_ACIC5A5G126, SYDND_ACICJB9ME28, SYDND_ACIET
B7J3F7, SYDND_ACIF2B5EJL3, SYDND_ACIF5A1W4E1, SYDND_ACISJ
Q9Y9U7, SYDND_AERPEB6JGJ7, SYDND_AFIC5Q8UG87, SYDND_AGRFC
B9JCV9, SYDND_AGRRKQ21YX2, SYDND_ALBFTQ0VRK1, SYDND_ALCBS
A8ESW7, SYDND_ALIB4Q0A582, SYDND_ALKEHB9JV61, SYDND_ALLAM
B8JH60, SYDND_ANAD2Q2IKX7, SYDND_ANADEB9KHS0, SYDND_ANAMF
Q2GLD8, SYDND_ANAPZB4UIE3, SYDND_ANASKB7GFR1, SYDND_ANOFW
O67589, SYDND_AQUAEO29342, SYDND_ARCFUQ5P280, SYDND_AROAE
A0JXA1, SYDND_ARTS2A8IFX1, SYDND_AZOC5A1KAJ9, SYDND_AZOSB
C1DRG2, SYDND_AZOVDC3P990, SYDND_BACAAC3L608, SYDND_BACAC
A0RJ11, SYDND_BACAHQ81LI7, SYDND_BACANB7JPY8, SYDND_BACC0
Q730D1, SYDND_BACC1B7IIR4, SYDND_BACC2C1ESU7, SYDND_BACC3
B7HE37, SYDND_BACC4B7HQG0, SYDND_BACC7A7GT84, SYDND_BACCN
B9IYX5, SYDND_BACCQQ817X8, SYDND_BACCRQ634E3, SYDND_BACCZ
Q6HDC3, SYDND_BACHKA9VIM8, SYDND_BACMKO32038, SYDND_BACSU
A7Z750, SYDND_BACVZA1UT52, SYDND_BARBKQ6G330, SYDND_BARHE
Q6FZI4, SYDND_BARQUA9IVI2, SYDND_BART1Q6MI59, SYDND_BDEBA
B2IKA4, SYDND_BEII9C5C5S1, SYDND_BEUC1B3DPM0, SYDND_BIFLD
Q8G863, SYDND_BIFLOB7GPT0, SYDND_BIFLSQ2L1K6, SYDND_BORA1
Q0SN63, SYDND_BORAPQ7WR42, SYDND_BORBRO51402, SYDND_BORBU
B7J213, SYDND_BORBZB5RM04, SYDND_BORDLQ661H4, SYDND_BORGP
B2S0F0, SYDND_BORHDQ7W275, SYDND_BORPAA9IHE2, SYDND_BORPD
Q7W001, SYDND_BORPEB5RRQ0, SYDND_BORRAA1QZN3, SYDND_BORT9
Q89MP9, SYDND_BRADUC0R2C9, SYDND_BRAHWA5EIE6, SYDND_BRASB
A4YTC4, SYDND_BRASOB2S501, SYDND_BRUA1Q2YNA7, SYDND_BRUA2
A6X200, SYDND_BRUA4Q57DZ8, SYDND_BRUABA9MAD3, SYDND_BRUC2
C0RI89, SYDND_BRUMBP67012, SYDND_BRUMEA5VPT5, SYDND_BRUO2
B0CL77, SYDND_BRUSIP67013, SYDND_BRUSUB1YWF2, SYDND_BURA4
A0KAE8, SYDND_BURCHB4EBD1, SYDND_BURCJQ0BBZ1, SYDND_BURCM
Q39D20, SYDND_BURL3A9AFC7, SYDND_BURM1A3MNU6, SYDND_BURM7
A2S8L9, SYDND_BURM9Q62MP0, SYDND_BURMAA1V745, SYDND_BURMS
B1JYI9, SYDND_BURO0Q1BTP1, SYDND_BURO1A3NRK2, SYDND_BURP0
Q3JVY8, SYDND_BURP1A3N5V6, SYDND_BURP6Q63X93, SYDND_BURPS
Q2T132, SYDND_BURTAA4JHR9, SYDND_BURVGQ8RAI7, SYDND_CALS4
A7ZEH3, SYDND_CAMC1A0RQ71, SYDND_CAMFFA7I058, SYDND_CAMHC
A8FL61, SYDND_CAMJ8A7H4H2, SYDND_CAMJDQ9PHM7, SYDND_CAMJE
A1VZ00, SYDND_CAMJJQ5HVD1, SYDND_CAMJRQ3AA17, SYDND_CARHZ
B0SWQ6, SYDND_CAUSKQ9A734, SYDND_CAUVCB3PB55, SYDND_CELJU
A3PMK8, SYDND_CERS1Q3IZP1, SYDND_CERS4A4WPF7, SYDND_CERS5
B9KME7, SYDND_CERSKQ11JA7, SYDND_CHESBA9WGJ7, SYDND_CHLAA
Q5L734, SYDND_CHLABB8G6W9, SYDND_CHLADQ3AS30, SYDND_CHLCH
Q46175, SYDND_CHLCVB3EDE5, SYDND_CHLL2Q3B3A1, SYDND_CHLL3
Q9PJK0, SYDND_CHLMUB3QP90, SYDND_CHLP8B3EQ26, SYDND_CHLPB
A1BGZ4, SYDND_CHLPDA4SF07, SYDND_CHLPMQ9Z7P2, SYDND_CHLPN
B9LJ78, SYDND_CHLSYB0B8B6, SYDND_CHLT2Q3KLF5, SYDND_CHLTA
B0B9Z5, SYDND_CHLTBQ8KCT7, SYDND_CHLTEO84546, SYDND_CHLTR
Q1QWG2, SYDND_CHRSDQ7NRP0, SYDND_CHRVOB5EIV1, SYDND_CITBB
Q483C7, SYDND_COLP3C3PGN5, SYDND_CORA7Q6NGZ4, SYDND_CORDI
Q8FT19, SYDND_COREFA4QEL0, SYDND_CORGBQ8NQ19, SYDND_CORGL
Q4JVF2, SYDND_CORJKC4LIW2, SYDND_CORK4B1VDL1, SYDND_CORU7
A9KF44, SYDND_COXBNA9N999, SYDND_COXBRQ83BE5, SYDND_COXBU
B1WRQ9, SYDND_CROS5Q1LRG2, SYDND_CUPMCQ0KEG8, SYDND_CUPNH
Q475W2, SYDND_CUPPJB2AH15, SYDND_CUPTRQ6A8J1, SYDND_CUTAK
B8HXQ8, SYDND_CYAP4Q47IE0, SYDND_DECARQ3Z8K0, SYDND_DEHM1
A5FRE3, SYDND_DEHMBQ3ZX84, SYDND_DEHMCQ9RVH4, SYDND_DEIRA
A9BP37, SYDND_DELASC0QFI1, SYDND_DESAHB8FKS6, SYDND_DESAL
A8ZUR7, SYDND_DESOHQ6AQS4, SYDND_DESPSA4J2J2, SYDND_DESRM
Q725Q7, SYDND_DESVHB5YDT0, SYDND_DICT6B8E1C0, SYDND_DICTD
A8LI32, SYDND_DINSHQ3YRF1, SYDND_EHRCJQ2GHC9, SYDND_EHRCR
Q5FG09, SYDND_EHRRGQ5HAL5, SYDND_EHRRWB2KBB9, SYDND_ELUMP
B1GZY6, SYDND_ENDTXQ2NBQ6, SYDND_ERYLHB0TW08, SYDND_FRAP2
A7N949, SYDND_FRATFQ2A622, SYDND_FRATHQ0BPA2, SYDND_FRATO
Q5NIQ4, SYDND_FRATTA4J0C7, SYDND_FRATWB9M1C9, SYDND_GEODF
Q39VY3, SYDND_GEOMGQ74D56, SYDND_GEOSLC6E3W7, SYDND_GEOSM
C5D509, SYDND_GEOSWA5G3L5, SYDND_GEOURB7KB89, SYDND_GLOC7
Q7NJA4, SYDND_GLOVIQ5FQ60, SYDND_GLUOXQ2SCK8, SYDND_HAHCH
Q5V1N2, SYDND_HALMAB8CXE5, SYDND_HALOHO07683, SYDND_HALSA
O24822, SYDND_HALVOQ18KP5, SYDND_HALWDQ17XK9, SYDND_HELAH
Q7VF76, SYDND_HELHPB0TF89, SYDND_HELMIB6JLK1, SYDND_HELP2
B5Z6Y8, SYDND_HELPGQ1CTQ7, SYDND_HELPHQ9ZLL9, SYDND_HELPJ
B2UTL0, SYDND_HELPSP56459, SYDND_HELPYA9B392, SYDND_HERA2
A4G8X1, SYDND_HERARQ31H87, SYDND_HYDCUB4U7P3, SYDND_HYDS0
Q0BZZ1, SYDND_HYPNAQ28MH9, SYDND_JANSCA6WCG5, SYDND_KINRD
A9KIA6, SYDND_LACP7C1DB91, SYDND_LARHHQ5X586, SYDND_LEGPA
A5IBW8, SYDND_LEGPCQ5ZVG2, SYDND_LEGPHQ5WWA3, SYDND_LEGPL
B1XWR8, SYDND_LEPCPA0L667, SYDND_MAGMMQ2W3D5, SYDND_MAGSA
Q0AQ87, SYDND_MARMMA6VXD0, SYDND_MARMSA1U1C2, SYDND_MARN8
A6USZ9, SYDND_META3Q8TQ68, SYDND_METACQ466Y5, SYDND_METBF
Q12XU7, SYDND_METBUB7KN33, SYDND_METC4Q607I4, SYDND_METCA
Q1GYN8, SYDND_METFKQ2FRU5, SYDND_METHJB3DX01, SYDND_METI4
Q58950, SYDND_METJAQ8TXG4, SYDND_METKAA2SPG1, SYDND_METLZ
A4G0V5, SYDND_METM5A9A945, SYDND_METM6A6VHK5, SYDND_METM7
Q8Q0R2, SYDND_METMAA3CXH4, SYDND_METMJQ6LWU0, SYDND_METMP
B8IUT2, SYDND_METNOB1ZFX6, SYDND_METPBA2SEP2, SYDND_METPP
B0UI66, SYDND_METS4B8EN55, SYDND_METSBQ2NHT0, SYDND_METST
O26328, SYDND_METTHA6UQQ8, SYDND_METVSB0JNW9, SYDND_MICAN
C5CCH2, SYDND_MICLCQ2RHW1, SYDND_MOOTAA0QI91, SYDND_MYCA1
B1MCH3, SYDND_MYCA9Q7TYA6, SYDND_MYCBOA4TBU4, SYDND_MYCGI
B8ZUJ3, SYDND_MYCLBP36429, SYDND_MYCLEQ741M7, SYDND_MYCPA
A0QWN3, SYDND_MYCS2A3PZ05, SYDND_MYCSJA1UFE5, SYDND_MYCSK
P9WFW2, SYDND_MYCTOP9WFW3, SYDND_MYCTUQ3IT59, SYDND_NATPD
B2A2G0, SYDND_NATTJB4RPA1, SYDND_NEIG2A9M257, SYDND_NEIM0
Q9JT23, SYDND_NEIMAQ9K0U5, SYDND_NEIMBA1KVG2, SYDND_NEIMF
Q0AIE4, SYDND_NITECQ82SQ5, SYDND_NITEUQ1QLI9, SYDND_NITHX
Q2YBG1, SYDND_NITMUQ3JEB6, SYDND_NITOCQ3SS92, SYDND_NITWN
Q5YTJ4, SYDND_NOCFAA1SJB8, SYDND_NOCSJB2J116, SYDND_NOSP7
Q8YUB6, SYDND_NOSS1Q2G8P1, SYDND_NOVADQ317R3, SYDND_OLEA2
B1ZSW8, SYDND_OPITPA5CC91, SYDND_ORITBB3CV53, SYDND_ORITI
A1B431, SYDND_PARDPA7HYC4, SYDND_PARL1Q7U3K6, SYDND_PARMW
B2JCV5, SYDND_PARP8B2SX42, SYDND_PARPJQ6ME91, SYDND_PARUW
Q145N3, SYDND_PARXLB4SAH1, SYDND_PELPBA5D3E3, SYDND_PELTS
Q4FMP8, SYDND_PELUBC0QT74, SYDND_PERMHB4RCT1, SYDND_PHEZH
B4S8V2, SYDND_PROA2A3PFH7, SYDND_PROM0A8G7J3, SYDND_PROM2
A2CDX5, SYDND_PROM3A9BDD8, SYDND_PROM4A2BZ75, SYDND_PROM5
Q317V3, SYDND_PROM9Q7V9I1, SYDND_PROMAQ7V3X1, SYDND_PROMM
Q7UZH8, SYDND_PROMPA2BTS0, SYDND_PROMSQ46I98, SYDND_PROMT
Q48FC1, SYDND_PSE14Q15RN2, SYDND_PSEA6B7UXW9, SYDND_PSEA8
Q02IC5, SYDND_PSEABQ51422, SYDND_PSEAEB8H9C7, SYDND_PSECP
Q1I6E5, SYDND_PSEE4Q4K7D5, SYDND_PSEF5C3JYT1, SYDND_PSEFS
A4XRR7, SYDND_PSEMYA5VZU3, SYDND_PSEP1Q3K7V6, SYDND_PSEPF
B0KTJ6, SYDND_PSEPGQ88NJ4, SYDND_PSEPKB1JD74, SYDND_PSEPW
Q87Y31, SYDND_PSESMQ4ZWL5, SYDND_PSEU2Q4FSF4, SYDND_PSYA2
Q1QBI9, SYDND_PSYCKA1SST6, SYDND_PSYINA5WE50, SYDND_PSYWF
Q8Y270, SYDND_RALN1Q1MIW0, SYDND_RHIL3Q983E9, SYDND_RHILO
B5ZX21, SYDND_RHILWQ92QV4, SYDND_RHIMEQ7UFY6, SYDND_RHOBA
B6IN46, SYDND_RHOCSC0ZZA3, SYDND_RHOE4Q0S0P3, SYDND_RHOJR
C1B4G8, SYDND_RHOOBQ2IX59, SYDND_RHOP2Q07LH5, SYDND_RHOP5
Q6N5D6, SYDND_RHOPAQ215P7, SYDND_RHOPBQ135R5, SYDND_RHOPS
B3Q9Q1, SYDND_RHOPTQ2RSM3, SYDND_RHORTC3PMI3, SYDND_RICAE
A8GMB3, SYDND_RICAHA8GXC5, SYDND_RICB8Q1RJN4, SYDND_RICBR
A8EXL4, SYDND_RICCKQ92J82, SYDND_RICCNQ4UKE2, SYDND_RICFE
Q9ZE17, SYDND_RICPRQ68XM3, SYDND_RICTYB7JX16, SYDND_RIPO1
A7NQH9, SYDND_ROSCSQ16B16, SYDND_ROSDOA5UUR3, SYDND_ROSS1
Q1AWB4, SYDND_RUBXDQ5LUX6, SYDND_RUEPOQ1GIZ8, SYDND_RUEST
A1AW56, SYDND_RUTMCQ21MA4, SYDND_SACD2A4FBC3, SYDND_SACEN
Q980V3, SYDND_SACS2A8LXY1, SYDND_SALAIQ2S158, SYDND_SALRD
A4X5Y3, SYDND_SALTOC3M9G8, SYDND_SINFNA6U7M8, SYDND_SINMW
Q8DSG3, SYDND_STRMUQ30RL7, SYDND_SULDNA6QAE8, SYDND_SULNB
B2V713, SYDND_SULSYQ976I3, SYDND_SULTOQ67LP0, SYDND_SYMTH
Q3A5R7, SYDND_SYNC1Q31NM6, SYDND_SYNE7Q2JTZ2, SYDND_SYNJA
Q2JMA8, SYDND_SYNJBB1XNY9, SYDND_SYNP2Q5N5I8, SYDND_SYNP6
A5GPL9, SYDND_SYNPWA5GWT2, SYDND_SYNR3Q3AVS9, SYDND_SYNS9
Q3AGF9, SYDND_SYNSCQ0AYS1, SYDND_SYNWWP73851, SYDND_SYNY3
C5BPP4, SYDND_TERTTQ47N50, SYDND_THEFYQ9X1F4, SYDND_THEMA
B9K8E5, SYDND_THENNB0K978, SYDND_THEP3B0K0N5, SYDND_THEPX
B1LBH9, SYDND_THESQQ5SIC2, SYDND_THET8Q8DJS8, SYDND_THEVB
B5YJP5, SYDND_THEYDQ3SLL2, SYDND_THIDAB8GUK0, SYDND_THISH
Q73MC2, SYDND_TREDEO83950, SYDND_TREPAB2S4M2, SYDND_TREPS
Q112K0, SYDND_TRIEIQ3MGL3, SYDND_TRIV2C5CWX8, SYDND_VARPS
A1WHI6, SYDND_VEREIQ73HX6, SYDND_WOLPMB3CPJ5, SYDND_WOLPP
Q7M8A6, SYDND_WOLSUQ5GTS0, SYDND_WOLTRC0R2K4, SYDND_WOLWR
A7IK27, SYDND_XANP2Q5NPM1, SYDND_ZYMMO

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All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 6.1.1.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 6.1.-.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 6.-.-.-