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ENZYME

ENZYME entry: EC 6.1.1.23

PURL: https://purl.expasy.org/enzyme/EC/6.1.1.23
Accepted Name
aspartate--tRNA(Asn) ligase
Alternative Name(s)
nondiscriminating aspartyl-tRNA synthetase
Reaction catalysed
tRNA(Asx) + L-aspartate + ATP = L-aspartyl-tRNA(Asx) + AMP + diphosphate
Comment(s)
  • When this enzyme acts on tRNA(Asp), it catalyzes the same reaction as EC 6.1.1.12.
  • It has, however, diminished discrimination, so that it can also form aspartyl-tRNA(Asn).
  • This relaxation of specificity has been found to result from the absence of a loop in the tRNA that specifically recognizes the third position of the anticodon.
  • This accounts for the ability of this enzyme in, for example, Thermus thermophilus, to recognize both tRNA(Asp) (GUC anticodon) and tRNA(Asn) (GUU anticodon).
  • The aspartate-tRNA(Asn) is not used in protein synthesis until it is converted by EC 6.3.5.6 into asparaginyl-tRNA(Asn).
Cross-references
BRENDA6.1.1.23
EC2PDB6.1.1.23
ExplorEnz6.1.1.23
KEGG Ligand Database for Enzyme Nomenclature6.1.1.23
IUBMB Enzyme Nomenclature6.1.1.23
MEDLINEFind literature relating to 6.1.1.23
MetaCyc6.1.1.23
Rhea expert-curated reactions6.1.1.23
UniProtKB/Swiss-Prot
Q2LPW5, SYDN1_SYNASQ2LTE0, SYDN2_SYNASB0CF01, SYDND_ACAM1
Q6FEH6, SYDND_ACIADB7GWN1, SYDND_ACIB3B7I8M5, SYDND_ACIB5
B2HYL7, SYDND_ACIBCB0VRC7, SYDND_ACIBSA3M8Q6, SYDND_ACIBT
B0V550, SYDND_ACIBYA0LUJ6, SYDND_ACIC1C1FAE8, SYDND_ACIC5
A5G126, SYDND_ACICJB9ME28, SYDND_ACIETB7J3F7, SYDND_ACIF2
B5EJL3, SYDND_ACIF5A1W4E1, SYDND_ACISJQ9Y9U7, SYDND_AERPE
B6JGJ7, SYDND_AFIC5Q8UG87, SYDND_AGRFCQ21YX2, SYDND_ALBFT
Q0VRK1, SYDND_ALCBSA8ESW7, SYDND_ALIB4Q0A582, SYDND_ALKEH
B9JV61, SYDND_ALLAMB8JH60, SYDND_ANAD2Q2IKX7, SYDND_ANADE
B9KHS0, SYDND_ANAMFQ2GLD8, SYDND_ANAPZB4UIE3, SYDND_ANASK
B7GFR1, SYDND_ANOFWO67589, SYDND_AQUAEO29342, SYDND_ARCFU
Q5P280, SYDND_AROAEA0JXA1, SYDND_ARTS2A8IFX1, SYDND_AZOC5
A1KAJ9, SYDND_AZOSBC1DRG2, SYDND_AZOVDC3P990, SYDND_BACAA
C3L608, SYDND_BACACA0RJ11, SYDND_BACAHQ81LI7, SYDND_BACAN
B7JPY8, SYDND_BACC0Q730D1, SYDND_BACC1B7IIR4, SYDND_BACC2
C1ESU7, SYDND_BACC3B7HE37, SYDND_BACC4B7HQG0, SYDND_BACC7
A7GT84, SYDND_BACCNB9IYX5, SYDND_BACCQQ817X8, SYDND_BACCR
Q634E3, SYDND_BACCZQ6HDC3, SYDND_BACHKA9VIM8, SYDND_BACMK
O32038, SYDND_BACSUA7Z750, SYDND_BACVZA1UT52, SYDND_BARBK
Q6G330, SYDND_BARHEQ6FZI4, SYDND_BARQUA9IVI2, SYDND_BART1
Q6MI59, SYDND_BDEBAB2IKA4, SYDND_BEII9C5C5S1, SYDND_BEUC1
B3DPM0, SYDND_BIFLDQ8G863, SYDND_BIFLOB7GPT0, SYDND_BIFLS
Q2L1K6, SYDND_BORA1Q0SN63, SYDND_BORAPQ7WR42, SYDND_BORBR
O51402, SYDND_BORBUB7J213, SYDND_BORBZB5RM04, SYDND_BORDL
Q661H4, SYDND_BORGPB2S0F0, SYDND_BORHDQ7W275, SYDND_BORPA
A9IHE2, SYDND_BORPDQ7W001, SYDND_BORPEB5RRQ0, SYDND_BORRA
A1QZN3, SYDND_BORT9Q89MP9, SYDND_BRADUC0R2C9, SYDND_BRAHW
A5EIE6, SYDND_BRASBA4YTC4, SYDND_BRASOB2S501, SYDND_BRUA1
Q2YNA7, SYDND_BRUA2A6X200, SYDND_BRUA4Q57DZ8, SYDND_BRUAB
A9MAD3, SYDND_BRUC2C0RI89, SYDND_BRUMBP67012, SYDND_BRUME
A5VPT5, SYDND_BRUO2B0CL77, SYDND_BRUSIP67013, SYDND_BRUSU
B1YWF2, SYDND_BURA4A0KAE8, SYDND_BURCHB4EBD1, SYDND_BURCJ
Q0BBZ1, SYDND_BURCMQ39D20, SYDND_BURL3A9AFC7, SYDND_BURM1
A3MNU6, SYDND_BURM7A2S8L9, SYDND_BURM9Q62MP0, SYDND_BURMA
A1V745, SYDND_BURMSB1JYI9, SYDND_BURO0Q1BTP1, SYDND_BURO1
A3NRK2, SYDND_BURP0Q3JVY8, SYDND_BURP1A3N5V6, SYDND_BURP6
Q63X93, SYDND_BURPSQ2T132, SYDND_BURTAA4JHR9, SYDND_BURVG
Q8RAI7, SYDND_CALS4A7ZEH3, SYDND_CAMC1A0RQ71, SYDND_CAMFF
A7I058, SYDND_CAMHCA8FL61, SYDND_CAMJ8A7H4H2, SYDND_CAMJD
Q9PHM7, SYDND_CAMJEA1VZ00, SYDND_CAMJJQ5HVD1, SYDND_CAMJR
Q3AA17, SYDND_CARHZB0SWQ6, SYDND_CAUSKQ9A734, SYDND_CAUVC
B3PB55, SYDND_CELJUA3PMK8, SYDND_CERS1Q3IZP1, SYDND_CERS4
A4WPF7, SYDND_CERS5B9KME7, SYDND_CERSKQ11JA7, SYDND_CHESB
A9WGJ7, SYDND_CHLAAQ5L734, SYDND_CHLABB8G6W9, SYDND_CHLAD
Q3AS30, SYDND_CHLCHQ46175, SYDND_CHLCVB3EDE5, SYDND_CHLL2
Q3B3A1, SYDND_CHLL3Q9PJK0, SYDND_CHLMUB3QP90, SYDND_CHLP8
B3EQ26, SYDND_CHLPBA1BGZ4, SYDND_CHLPDA4SF07, SYDND_CHLPM
Q9Z7P2, SYDND_CHLPNB9LJ78, SYDND_CHLSYB0B8B6, SYDND_CHLT2
Q3KLF5, SYDND_CHLTAB0B9Z5, SYDND_CHLTBQ8KCT7, SYDND_CHLTE
O84546, SYDND_CHLTRQ1QWG2, SYDND_CHRSDQ7NRP0, SYDND_CHRVO
B5EIV1, SYDND_CITBBQ483C7, SYDND_COLP3C3PGN5, SYDND_CORA7
Q6NGZ4, SYDND_CORDIQ8FT19, SYDND_COREFA4QEL0, SYDND_CORGB
Q8NQ19, SYDND_CORGLQ4JVF2, SYDND_CORJKC4LIW2, SYDND_CORK4
B1VDL1, SYDND_CORU7A9KF44, SYDND_COXBNA9N999, SYDND_COXBR
Q83BE5, SYDND_COXBUB1WRQ9, SYDND_CROS5Q1LRG2, SYDND_CUPMC
Q0KEG8, SYDND_CUPNHQ475W2, SYDND_CUPPJB2AH15, SYDND_CUPTR
Q6A8J1, SYDND_CUTAKB8HXQ8, SYDND_CYAP4Q47IE0, SYDND_DECAR
Q3Z8K0, SYDND_DEHM1A5FRE3, SYDND_DEHMBQ3ZX84, SYDND_DEHMC
Q9RVH4, SYDND_DEIRAA9BP37, SYDND_DELASC0QFI1, SYDND_DESAH
B8FKS6, SYDND_DESALA8ZUR7, SYDND_DESOHQ6AQS4, SYDND_DESPS
A4J2J2, SYDND_DESRMB5YDT0, SYDND_DICT6B8E1C0, SYDND_DICTD
A8LI32, SYDND_DINSHA4XRR7, SYDND_ECTM1Q3YRF1, SYDND_EHRCJ
Q2GHC9, SYDND_EHRCRQ5FG09, SYDND_EHRRGQ5HAL5, SYDND_EHRRW
B2KBB9, SYDND_ELUMPB1GZY6, SYDND_ENDTXQ2NBQ6, SYDND_ERYLH
B0TW08, SYDND_FRAP2A7N949, SYDND_FRATFQ2A622, SYDND_FRATH
Q0BPA2, SYDND_FRATOQ5NIQ4, SYDND_FRATTA4J0C7, SYDND_FRATW
B9M1C9, SYDND_GEODFQ39VY3, SYDND_GEOMGQ74D56, SYDND_GEOSL
C6E3W7, SYDND_GEOSMC5D509, SYDND_GEOSWA5G3L5, SYDND_GEOUR
B7KB89, SYDND_GLOC7Q7NJA4, SYDND_GLOVIQ5FQ60, SYDND_GLUOX
Q2SCK8, SYDND_HAHCHQ5V1N2, SYDND_HALMAB8CXE5, SYDND_HALOH
O07683, SYDND_HALSAO24822, SYDND_HALVOQ18KP5, SYDND_HALWD
Q17XK9, SYDND_HELAHQ7VF76, SYDND_HELHPB0TF89, SYDND_HELMI
B6JLK1, SYDND_HELP2B5Z6Y8, SYDND_HELPGQ1CTQ7, SYDND_HELPH
Q9ZLL9, SYDND_HELPJB2UTL0, SYDND_HELPSP56459, SYDND_HELPY
A9B392, SYDND_HERA2A4G8X1, SYDND_HERARQ31H87, SYDND_HYDCU
B4U7P3, SYDND_HYDS0Q0BZZ1, SYDND_HYPNAQ28MH9, SYDND_JANSC
A6WCG5, SYDND_KINRDA9KIA6, SYDND_LACP7C1DB91, SYDND_LARHH
Q5X586, SYDND_LEGPAA5IBW8, SYDND_LEGPCQ5ZVG2, SYDND_LEGPH
Q5WWA3, SYDND_LEGPLB1XWR8, SYDND_LEPCPA0L667, SYDND_MAGMM
Q0AQ87, SYDND_MARMMA6VXD0, SYDND_MARMSA1U1C2, SYDND_MARN8
A6USZ9, SYDND_META3Q8TQ68, SYDND_METACQ466Y5, SYDND_METBF
Q12XU7, SYDND_METBUB7KN33, SYDND_METC4Q607I4, SYDND_METCA
Q1GYN8, SYDND_METFKQ2FRU5, SYDND_METHJB3DX01, SYDND_METI4
Q58950, SYDND_METJAQ8TXG4, SYDND_METKAA2SPG1, SYDND_METLZ
A4G0V5, SYDND_METM5A9A945, SYDND_METM6A6VHK5, SYDND_METM7
Q8Q0R2, SYDND_METMAA3CXH4, SYDND_METMJQ6LWU0, SYDND_METMP
B8IUT2, SYDND_METNOB1ZFX6, SYDND_METPBA2SEP2, SYDND_METPP
B0UI66, SYDND_METS4B8EN55, SYDND_METSBQ2NHT0, SYDND_METST
O26328, SYDND_METTHA6UQQ8, SYDND_METVSB0JNW9, SYDND_MICAN
C5CCH2, SYDND_MICLCQ2RHW1, SYDND_MOOTAA0QI91, SYDND_MYCA1
B1MCH3, SYDND_MYCA9Q7TYA6, SYDND_MYCBOA4TBU4, SYDND_MYCGI
B8ZUJ3, SYDND_MYCLBP36429, SYDND_MYCLEQ741M7, SYDND_MYCPA
A0QWN3, SYDND_MYCS2A3PZ05, SYDND_MYCSJA1UFE5, SYDND_MYCSK
P9WFW2, SYDND_MYCTOP9WFW3, SYDND_MYCTUQ3IT59, SYDND_NATPD
B2A2G0, SYDND_NATTJB4RPA1, SYDND_NEIG2A9M257, SYDND_NEIM0
Q9JT23, SYDND_NEIMAQ9K0U5, SYDND_NEIMBA1KVG2, SYDND_NEIMF
Q0AIE4, SYDND_NITECQ82SQ5, SYDND_NITEUQ1QLI9, SYDND_NITHX
Q2YBG1, SYDND_NITMUQ3JEB6, SYDND_NITOCQ725Q7, SYDND_NITV2
Q3SS92, SYDND_NITWNQ5YTJ4, SYDND_NOCFAA1SJB8, SYDND_NOCSJ
B2J116, SYDND_NOSP7Q8YUB6, SYDND_NOSS1Q2G8P1, SYDND_NOVAD
Q317R3, SYDND_OLEA2B1ZSW8, SYDND_OPITPA5CC91, SYDND_ORITB
B3CV53, SYDND_ORITIA1TT99, SYDND_PARC0A1B431, SYDND_PARDP
A7HYC4, SYDND_PARL1Q2W3D5, SYDND_PARM1Q7U3K6, SYDND_PARMW
B2JCV5, SYDND_PARP8B2SX42, SYDND_PARPJQ6ME91, SYDND_PARUW
Q145N3, SYDND_PARXLB4SAH1, SYDND_PELPBA5D3E3, SYDND_PELTS
Q4FMP8, SYDND_PELUBC0QT74, SYDND_PERMHB4RCT1, SYDND_PHEZH
B1XNY9, SYDND_PICP2B4S8V2, SYDND_PROA2A3PFH7, SYDND_PROM0
A8G7J3, SYDND_PROM2A2CDX5, SYDND_PROM3A9BDD8, SYDND_PROM4
A2BZ75, SYDND_PROM5Q317V3, SYDND_PROM9Q7V9I1, SYDND_PROMA
Q7V3X1, SYDND_PROMMQ7UZH8, SYDND_PROMPA2BTS0, SYDND_PROMS
Q46I98, SYDND_PROMTQ48FC1, SYDND_PSE14Q15RN2, SYDND_PSEA6
B7UXW9, SYDND_PSEA8Q02IC5, SYDND_PSEABQ51422, SYDND_PSEAE
B8H9C7, SYDND_PSECPQ1I6E5, SYDND_PSEE4Q4K7D5, SYDND_PSEF5
C3JYT1, SYDND_PSEFSA5VZU3, SYDND_PSEP1Q3K7V6, SYDND_PSEPF
B0KTJ6, SYDND_PSEPGQ88NJ4, SYDND_PSEPKB1JD74, SYDND_PSEPW
Q87Y31, SYDND_PSESMQ4ZWL5, SYDND_PSEU2Q4FSF4, SYDND_PSYA2
Q1QBI9, SYDND_PSYCKA1SST6, SYDND_PSYINA5WE50, SYDND_PSYWF
Q8Y270, SYDND_RALN1Q1MIW0, SYDND_RHIJ3Q983E9, SYDND_RHILO
B5ZX21, SYDND_RHILWQ92QV4, SYDND_RHIMEB9JCV9, SYDND_RHIR8
Q7UFY6, SYDND_RHOBAB6IN46, SYDND_RHOCSC0ZZA3, SYDND_RHOE4
Q0S0P3, SYDND_RHOJRC1B4G8, SYDND_RHOOBQ2IX59, SYDND_RHOP2
Q07LH5, SYDND_RHOP5Q6N5D6, SYDND_RHOPAQ215P7, SYDND_RHOPB
Q135R5, SYDND_RHOPSB3Q9Q1, SYDND_RHOPTQ2RSM3, SYDND_RHORT
C3PMI3, SYDND_RICAEA8GMB3, SYDND_RICAHA8GXC5, SYDND_RICB8
Q1RJN4, SYDND_RICBRA8EXL4, SYDND_RICCKQ92J82, SYDND_RICCN
Q4UKE2, SYDND_RICFEQ9ZE17, SYDND_RICPRQ68XM3, SYDND_RICTY
B7JX16, SYDND_RIPO1A7NQH9, SYDND_ROSCSQ16B16, SYDND_ROSDO
A5UUR3, SYDND_ROSS1Q1AWB4, SYDND_RUBXDQ5LUX6, SYDND_RUEPO
Q1GIZ8, SYDND_RUESTA1AW56, SYDND_RUTMCQ21MA4, SYDND_SACD2
A4FBC3, SYDND_SACENQ980V3, SYDND_SACS2A8LXY1, SYDND_SALAI
Q2S158, SYDND_SALRDA4X5Y3, SYDND_SALTOC3M9G8, SYDND_SINFN
A6U7M8, SYDND_SINMWQ8DSG3, SYDND_STRMUQ30RL7, SYDND_SULDN
A6QAE8, SYDND_SULNBB2V713, SYDND_SULSYQ976I3, SYDND_SULTO
Q67LP0, SYDND_SYMTHQ3A5R7, SYDND_SYNC1Q31NM6, SYDND_SYNE7
Q2JTZ2, SYDND_SYNJAQ2JMA8, SYDND_SYNJBQ5N5I8, SYDND_SYNP6
A5GPL9, SYDND_SYNPWA5GWT2, SYDND_SYNR3Q3AVS9, SYDND_SYNS9
Q3AGF9, SYDND_SYNSCQ0AYS1, SYDND_SYNWWP73851, SYDND_SYNY3
C5BPP4, SYDND_TERTTQ47N50, SYDND_THEFYQ9X1F4, SYDND_THEMA
B9K8E5, SYDND_THENNB0K978, SYDND_THEP3B0K0N5, SYDND_THEPX
B1LBH9, SYDND_THESQQ5SIC2, SYDND_THET8Q8DJS8, SYDND_THEVB
B5YJP5, SYDND_THEYDQ3SLL2, SYDND_THIDAB8GUK0, SYDND_THISH
Q73MC2, SYDND_TREDEO83950, SYDND_TREPAB2S4M2, SYDND_TREPS
Q112K0, SYDND_TRIEIQ3MGL3, SYDND_TRIV2C5CWX8, SYDND_VARPS
A1WHI6, SYDND_VEREIQ73HX6, SYDND_WOLPMB3CPJ5, SYDND_WOLPP
Q7M8A6, SYDND_WOLSUQ5GTS0, SYDND_WOLTRC0R2K4, SYDND_WOLWR
A7IK27, SYDND_XANP2Q5NPM1, SYDND_ZYMMO

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All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 6.1.1.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 6.1.-.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 6.-.-.-