ENZYME

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A new class EC 7, Translocases, has been added to the EC list. It will be part of ENZYME from release 2018_10. Read more about EC 7 here.

ENZYME entry: EC 6.3.5.6

Accepted Name
Asparaginyl-tRNA synthase (glutamine-hydrolyzing).
Alternative Name(s)
Asp-AdT.
Asp-tRNA(Asn) amidotransferase.
Aspartyl-tRNA(Asn) amidotransferase.
Reaction catalysed
ATP + L-aspartyl-tRNA(Asn) + L-glutamine + H(2)O <=> ADP + phosphate + L-asparaginyl-tRNA(Asn) + L-glutamate
Comment(s)
This reaction forms part of a two-reaction system for producing asparaginyl-tRNA in Deinococcus radiodurans and other organisms lacking a specific enzyme for asparagine synthesis. In the first step, a non-discriminating ligase (EC 6.1.1.23) mischarges tRNA(Asn) with aspartate, leading to the formation of aspartyl-tRNA(Asn). The aspartyl-tRNA(Asn) is not used in protein synthesis until the present enzyme converts it into asparaginyl-tRNA(Asn) (aspartyl- tRNA(Asp) is not a substrate for this reaction). Ammonia or asparagine can substitute for the preferred substrate glutamine.
Cross-references
BRENDA	6.3.5.6
EC2PDB	6.3.5.6
ExplorEnz	6.3.5.6
PRIAM enzyme-specific profiles	6.3.5.6
KEGG Ligand Database for Enzyme Nomenclature	6.3.5.6
IUBMB Enzyme Nomenclature	6.3.5.6
IntEnz	6.3.5.6
MEDLINE	Find literature relating to 6.3.5.6
MetaCyc	6.3.5.6