A new class EC 7, Translocases, has been added to the EC list. It will be part of ENZYME from release 2018_10. Read more about EC 7 here.
ENZYME entry: EC 184.108.40.206
View entry in original ENZYME format
View entry in raw text format (no links)
|Nondiscriminating glutamyl-tRNA synthetase.|
|ATP + L-glutamate + tRNA(Glx) <=> AMP + diphosphate + L-glutamyl-tRNA(Glx)|
- When this enzyme acts on tRNA(Glu), it catalyzes the same reaction as
- It has, however, diminished discrimination, so that it can also form
- This relaxation of specificity has been found to result from the
absence of a loop in the tRNA that specifically recognizes the third
position of the anticodon.
- This accounts for the ability of this enzyme in, for example,
Bacillus subtilis, to recognize both tRNA(1)(Gln) (UUG anticodon) and
tRNA(Glu) (UUC anticodon) but not tRNA(2)(Gln) (CUG anticodon).
- The ability of this enzyme to recognize both tRNA(Glu) and one of the
tRNA(Gln) isoacceptors derives from their sharing a major identity
element, a hypermodified derivative of U34 (5-methylaminomethyl-2-
- The glutamyl-tRNA(Gln) is not used in protein synthesis until it is
converted by EC 220.127.116.11 into glutaminyl-tRNA(Gln).
|PRIAM enzyme-specific profiles||18.104.22.168|
|KEGG Ligand Database for Enzyme Nomenclature||22.214.171.124|
|IUBMB Enzyme Nomenclature||126.96.36.199|
|MEDLINE||Find literature relating to 188.8.131.52|
entries corresponding to 6.1.1.-
entries corresponding to 6.1.-.-
entries corresponding to 6.-.-.-