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ENZYME

ENZYME entry: EC 6.1.2.1

PURL: https://purl.expasy.org/enzyme/EC/6.1.2.1
Accepted Name
D-alanine--(R)-lactate ligase
Reaction catalysed
(R)-lactate + D-alanine + ATP = D-alanyl-(R)-lactate + ADP + phosphate
Comment(s)
  • The product of this enzyme, the depsipeptide D-alanyl-(R)-lactate, can be incorporated into the peptidoglycan pentapeptide instead of the usual D-alanyl-D-alanine dipeptide, which is formed by EC 6.3.2.4.
  • The resulting peptidoglycan does not bind the glycopeptide antibiotics vancomycin and teicoplanin, conferring resistance on the bacteria.
Cross-references
BRENDA6.1.2.1
EC2PDB6.1.2.1
ExplorEnz6.1.2.1
KEGG Ligand Database for Enzyme Nomenclature6.1.2.1
IUBMB Enzyme Nomenclature6.1.2.1
MEDLINEFind literature relating to 6.1.2.1
MetaCyc6.1.2.1
Rhea expert-curated reactions6.1.2.1
UniProtKB/Swiss-Prot
P25051, VANA_ENTFCQ06893, VANB_ENTFA

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