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A new class EC 7, Translocases, has been added to the EC list. It will be part of ENZYME from release 2018_10. Read more about EC 7 here.

ENZYME entry: EC

Accepted Name
D-alanine--(R)-lactate ligase.
Reaction catalysed
D-alanine + (R)-lactate + ATP <=> D-alanyl-(R)-lactate + ADP + phosphate
  • The product of this enzyme, the depsipeptide D-alanyl-(R)-lactate, can be incorporated into the peptidoglycan pentapeptide instead of the usual D-alanyl-D-alanine dipeptide, which is formed by EC
  • The resulting peptidoglycan does not bind the glycopeptide antibiotics vancomycin and teicoplanin, conferring resistance on the bacteria.
PRIAM enzyme-specific profiles6.1.2.1
KEGG Ligand Database for Enzyme Nomenclature6.1.2.1
IUBMB Enzyme Nomenclature6.1.2.1
MEDLINEFind literature relating to
P25051, VANA_ENTFC;  Q06893, VANB_ENTFA;  

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All UniProtKB/Swiss-Prot entries referenced in this entry, with possibility to download in different formats, align etc.
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 6.1.2.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 6.1.-.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 6.-.-.-