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ENZYME

ENZYME entry: EC 6.3.2.10

PURL: https://purl.expasy.org/enzyme/EC/6.3.2.10
Accepted Name
UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase
Alternative Name(s)
MurF synthetase
UDPacetylmuramoylpentapeptide synthetase
UDP-MurNAc-L-Ala-D-Glu-L-Lys:D-Ala-D-Ala ligase
UDP-MurNAc-pentapeptide synthetase
UDP-N-acetylmuramoylalanine-D-glutamyl-lysine--D-alanyl-D-alanine ligase
UDP-N-acetylmuramoylalanyl-D-glutamyl-2,6-diaminopimelate--D-alanyl-D- alanine ligase
UDP-N-acetylmuramoylalanyl-D-glutamyl-lysine-D-alanyl-D-alanine ligase
UDP-N-acetylmuramoyl-L-alanyl-D-glutamyl-L-lysyl-D-alanyl-D-alanine synthetase
UDP-N-acetylmuramoyl-L-alanyl-D-glutamyl-meso-2,6-diaminopimeloyl-D- alanyl-D-alanine synthetase
uridine diphosphoacetylmuramoylpentapeptide synthetase
Reaction catalysed
UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-gamma-D-glutamyl-L-lysine + D-alanyl-D-alanine + ATP = UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-gamma-D-glutamyl-L-lysyl-D-alanyl-D-alanine + ADP + phosphate + H(+)
Comment(s)
  • Involved with EC 6.3.2.4, EC 6.3.2.7 or EC 6.3.2.13, EC 6.3.2.8 and EC 6.3.2.9 in the synthesis of a cell-wall peptide.
  • Also catalyzes the reaction when the C-terminal residue of the tripeptide is meso-2,6-diaminoheptanedioate (acylated at its L-center), linking the D-Ala--D-Ala to the carboxy group of the L-center.
  • Formerly EC 6.3.2.15.
Cross-references
BRENDA6.3.2.10
EC2PDB6.3.2.10
ExplorEnz6.3.2.10
KEGG Ligand Database for Enzyme Nomenclature6.3.2.10
IUBMB Enzyme Nomenclature6.3.2.10
MEDLINEFind literature relating to 6.3.2.10
MetaCyc6.3.2.10
Rhea expert-curated reactions6.3.2.10
UniProtKB/Swiss-Prot
P96613, MURF_BACSUQ44777, MURF_BORBUP57315, MURF_BUCAI
Q89AQ1, MURF_BUCBPP11880, MURF_ECOLIP45061, MURF_HAEIN
P0A5L5, MURF_MYCBOO69556, MURF_MYCLEP9WJL0, MURF_MYCTO
P9WJL1, MURF_MYCTUQ92H60, MURF_RICCNQ9AKP1, MURF_RICMO
O05953, MURF_RICPRQ2FWH4, MURF_STAA8A0A0H2WWP1, MURF_STAAC
O33804, MURF_STRTOP45450, MURF_SYNY3O83401, MURF_TREPA

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