ENZYME entry: EC 6.3.2.10

Accepted Name

UDP-N-acetylmuramoyl-tripeptide--D-alanyl-D-alanine ligase

Alternative Name(s)

MurF synthetase

UDPacetylmuramoylpentapeptide synthetase

UDP-MurNAc-L-Ala-D-Glu-L-Lys:D-Ala-D-Ala ligase

UDP-MurNAc-pentapeptide synthetase

UDP-N-acetylmuramoylalanine-D-glutamyl-lysine--D-alanyl-D-alanine ligase

UDP-N-acetylmuramoylalanyl-D-glutamyl-2,6-diaminopimelate--D-alanyl-D- alanine ligase

UDP-N-acetylmuramoylalanyl-D-glutamyl-lysine-D-alanyl-D-alanine ligase

UDP-N-acetylmuramoyl-L-alanyl-D-glutamyl-L-lysyl-D-alanyl-D-alanine synthetase

UDP-N-acetylmuramoyl-L-alanyl-D-glutamyl-meso-2,6-diaminopimeloyl-D- alanyl-D-alanine synthetase

uridine diphosphoacetylmuramoylpentapeptide synthetase

Reaction catalysed

ATP + D-alanyl-D-alanine + UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-gamma-D-glutamyl-L-lysine <=> ADP + H(+) + phosphate + UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-gamma-D-glutamyl-L-lysyl-D-alanyl-D-alanine

Comment(s)

Involved with EC 6.3.2.4, EC 6.3.2.7 or EC 6.3.2.13, EC 6.3.2.8 and EC 6.3.2.9 in the synthesis of a cell-wall peptide.
Also catalyzes the reaction when the C-terminal residue of the tripeptide is meso-2,6-diaminoheptanedioate (acylated at its L-center), linking the D-Ala--D-Ala to the carboxy group of the L-center.
Formerly EC 6.3.2.15.

Cross-references

BRENDA

6.3.2.10

EC2PDB

6.3.2.10

ExplorEnz

6.3.2.10

PRIAM enzyme-specific profiles

6.3.2.10

KEGG Ligand Database for Enzyme Nomenclature

6.3.2.10

IUBMB Enzyme Nomenclature

6.3.2.10

IntEnz

6.3.2.10

MEDLINE

Find literature relating to 6.3.2.10

MetaCyc

6.3.2.10

Rhea expert-curated reactions

6.3.2.10

UniProtKB/Swiss-Prot

P96613, MURF_BACSU	Q44777, MURF_BORBU	P57315, MURF_BUCAI
Q89AQ1, MURF_BUCBP	P11880, MURF_ECOLI	P45061, MURF_HAEIN
P0A5L5, MURF_MYCBO	O69556, MURF_MYCLE	P9WJL0, MURF_MYCTO
P9WJL1, MURF_MYCTU	Q92H60, MURF_RICCN	Q9AKP1, MURF_RICMO
O05953, MURF_RICPR	Q2FWH4, MURF_STAA8	A0A0H2WWP1, MURF_STAAC
O33804, MURF_STRTO	P45450, MURF_SYNY3	O83401, MURF_TREPA

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All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 6.3.2.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 6.3.-.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 6.-.-.-