ENZYME entry: EC 6.3.2.14
Accepted Name |
Enterobactin synthase.
|
Alternative Name(s) |
2,3-dihydroxybenzoate--serine ligase. |
N-(2,3-dihydroxybenzoyl)-serine synthetase. |
Reaction catalysed |
6 ATP + 3 2,3-dihydroxybenzoate + 3 L-serine <=> enterobactin + 6 AMP + 6 diphosphate |
Comment(s) |
- This enzyme complex catalyzes the conversion of three molecules each
of 2,3-dihydroxybenzoate and L-serine to form the siderophore
enterobactin.
- In Escherichia coli the complex is formed by EntB (an aryl carrier
protein that has to be activated by 4'-phosphopantetheine), EntD (a
phosphopantetheinyl transferase that activates EntB), EntE (catalyzes
the ATP-dependent condensation of 2,3-dihydroxybenzoate and holo-EntB
to form the covalently arylated form of EntB), and EntF (a four
domain protein that catalyzes the activation of L-serine by ATP,
the condensation of the activated L-serine with the activated 2,3-
dihydroxybenzoate, and the trimerization of three such moieties to a
single enterobactin molecule).
|
Cross-references |
BRENDA | 6.3.2.14 |
EC2PDB | 6.3.2.14 |
ExplorEnz | 6.3.2.14 |
PRIAM enzyme-specific profiles | 6.3.2.14 |
KEGG Ligand Database for Enzyme Nomenclature | 6.3.2.14 |
IUBMB Enzyme Nomenclature | 6.3.2.14 |
IntEnz | 6.3.2.14 |
MEDLINE | Find literature relating to 6.3.2.14 |
MetaCyc | 6.3.2.14 |
UniProtKB/Swiss-Prot |
|
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