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ENZYME entry: EC 6.3.2.14

Accepted Name
enterobactin synthase.
Alternative Name(s)
2,3-dihydroxybenzoate--serine ligase.
N-(2,3-dihydroxybenzoyl)-serine synthetase.
Reaction catalysed
3 2,3-dihydroxybenzoate + 6 ATP + 3 L-serine <=> 6 AMP + 6 diphosphate + enterobactin + 4 H(+)
Comment(s)
  • This enzyme complex catalyzes the conversion of three molecules each of 2,3-dihydroxybenzoate and L-serine to form the siderophore enterobactin.
  • In Escherichia coli the complex is formed by EntB (an aryl carrier protein that has to be activated by 4'-phosphopantetheine), EntD (a phosphopantetheinyl transferase that activates EntB), EntE (catalyzes the ATP-dependent condensation of 2,3-dihydroxybenzoate and holo-EntB to form the covalently arylated form of EntB), and EntF (a four domain protein that catalyzes the activation of L-serine by ATP, the condensation of the activated L-serine with the activated 2,3- dihydroxybenzoate, and the trimerization of three such moieties to a single enterobactin molecule).
Cross-references
BRENDA6.3.2.14
EC2PDB6.3.2.14
ExplorEnz6.3.2.14
PRIAM enzyme-specific profiles6.3.2.14
KEGG Ligand Database for Enzyme Nomenclature6.3.2.14
IUBMB Enzyme Nomenclature6.3.2.14
IntEnz6.3.2.14
MEDLINEFind literature relating to 6.3.2.14
MetaCyc6.3.2.14
Rhea expert-curated reactions6.3.2.14
UniProtKB/Swiss-Prot
P0ADI5, ENTB_ECO57;  P0ADI4, ENTB_ECOLI;  P0ADI6, ENTB_SHIFL;  
Q8XBV3, ENTE_ECO57;  P10378, ENTE_ECOLI;  Q8XBV9, ENTF_ECO57;  
P11454, ENTF_ECOLI;  P29698, ENTF_SHIFL;  

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