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ENZYME

ENZYME entry: EC 6.3.2.25

PURL: https://purl.expasy.org/enzyme/EC/6.3.2.25
Accepted Name
tubulin--tyrosine ligase
Alternative Name(s)
TTL
Reaction catalysed
C-terminal L-alpha-aminoacyl-L-glutamyl-L-glutamyl-[tubulin] + L-tyrosine + ATP = C-terminal L-alpha-aminoacyl-L-glutamyl-L-glutamyl-L-tyrosyl-[tubulin] + ADP + phosphate + H(+)
Comment(s)
  • L-Tyrosine is linked via a peptide bond to the C-terminus of de-tyrosinated alpha-tubulin (des-Tyr(omega)-alpha-tubulin).
  • The enzyme is highly specific for alpha-tubulin and moderately specific for ATP and L-tyrosine.
  • L-Phenylalanine and 3,4-dihydroxy-L-phenylalanine are transferred but with higher Km values.
Cross-references
BRENDA6.3.2.25
EC2PDB6.3.2.25
ExplorEnz6.3.2.25
KEGG Ligand Database for Enzyme Nomenclature6.3.2.25
IUBMB Enzyme Nomenclature6.3.2.25
MEDLINEFind literature relating to 6.3.2.25
MetaCyc6.3.2.25
Rhea expert-curated reactions6.3.2.25
UniProtKB/Swiss-Prot
P38584, TTL_BOVINQ8NG68, TTL_HUMANP38585, TTL_MOUSE
P38160, TTL_PIGQ9QXJ0, TTL_RATQ10438, TTL_SCHPO
P38254, TTL_YEAST

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All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 6.3.2.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 6.3.-.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 6.-.-.-