ENZYME entry: EC 6.3.2.25
Accepted Name |
Tubulin--tyrosine ligase.
|
Alternative Name(s) |
TTL. |
Reaction catalysed |
ATP + detyrosinated alpha-tubulin + L-tyrosine <=> alpha-tubulin + ADP + phosphate |
Comment(s) |
- L-tyrosine is linked via a peptide bond to the C-terminus of
de-tyrosinated alpha-tubulin (des-Tyr(omega)-alpha-tubulin).
- The enzyme is highly specific for alpha-tubulin and moderately
specific for ATP and L-tyrosine.
- L-phenylalanine and 3,4-dihydroxy-L-phenylalanine are transferred but
with higher Km values.
|
Cross-references |
PROSITE | PDOC51221 |
BRENDA | 6.3.2.25 |
EC2PDB | 6.3.2.25 |
ExplorEnz | 6.3.2.25 |
PRIAM enzyme-specific profiles | 6.3.2.25 |
KEGG Ligand Database for Enzyme Nomenclature | 6.3.2.25 |
IUBMB Enzyme Nomenclature | 6.3.2.25 |
IntEnz | 6.3.2.25 |
MEDLINE | Find literature relating to 6.3.2.25 |
MetaCyc | 6.3.2.25 |
UniProtKB/Swiss-Prot |
|
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