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ENZYME entry: EC 6.3.2.25

Accepted Name
Tubulin--tyrosine ligase.
Alternative Name(s)
TTL.
Reaction catalysed
ATP + detyrosinated alpha-tubulin + L-tyrosine <=> alpha-tubulin + ADP + phosphate
Comment(s)
  • L-tyrosine is linked via a peptide bond to the C-terminus of de-tyrosinated alpha-tubulin (des-Tyr(omega)-alpha-tubulin).
  • The enzyme is highly specific for alpha-tubulin and moderately specific for ATP and L-tyrosine.
  • L-phenylalanine and 3,4-dihydroxy-L-phenylalanine are transferred but with higher Km values.
Cross-references
PROSITEPDOC51221
BRENDA6.3.2.25
EC2PDB6.3.2.25
ExplorEnz6.3.2.25
PRIAM enzyme-specific profiles6.3.2.25
KEGG Ligand Database for Enzyme Nomenclature6.3.2.25
IUBMB Enzyme Nomenclature6.3.2.25
IntEnz6.3.2.25
MEDLINEFind literature relating to 6.3.2.25
MetaCyc6.3.2.25
Rhea expert-curated reactions6.3.2.25
UniProtKB/Swiss-Prot
P38584, TTL_BOVIN;  Q8NG68, TTL_HUMAN;  P38585, TTL_MOUSE;  
P38160, TTL_PIG;  Q9QXJ0, TTL_RAT;  Q10438, TTL_SCHPO;  
P38254, TTL_YEAST;  

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