ENZYME entry: EC 6.3.2.25
| Accepted Name |
|---|
| tubulin--tyrosine ligase.
|
| Alternative Name(s) |
|---|
| TTL. |
| Reaction catalysed |
|---|
| ATP + C-terminal L-alpha-aminoacyl-L-glutamyl-L-glutamyl-[tubulin] + L-tyrosine <=> ADP + C-terminal L-alpha-aminoacyl-L-glutamyl-L-glutamyl-L-tyrosyl-[tubulin] + H(+) + phosphate |
| Comment(s) |
|---|
- L-Tyrosine is linked via a peptide bond to the C-terminus of
de-tyrosinated alpha-tubulin (des-Tyr(omega)-alpha-tubulin).
- The enzyme is highly specific for alpha-tubulin and moderately
specific for ATP and L-tyrosine.
- L-Phenylalanine and 3,4-dihydroxy-L-phenylalanine are transferred but
with higher Km values.
|
| Cross-references |
|---|
| BRENDA | 6.3.2.25 |
| EC2PDB | 6.3.2.25 |
| ExplorEnz | 6.3.2.25 |
| PRIAM enzyme-specific profiles | 6.3.2.25 |
| KEGG Ligand Database for Enzyme Nomenclature | 6.3.2.25 |
| IUBMB Enzyme Nomenclature | 6.3.2.25 |
| IntEnz | 6.3.2.25 |
| MEDLINE | Find literature relating to 6.3.2.25 |
| MetaCyc | 6.3.2.25 |
| Rhea expert-curated reactions | 6.3.2.25 |
| UniProtKB/Swiss-Prot |
|
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