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ENZYME entry: EC 6.3.2.26

Accepted Name
N-(5-amino-5-carboxypentanoyl)-L-cysteinyl-D-valine synthase.
Alternative Name(s)
ACV synthetase.
L-alpha-aminoadipyl-cysteinyl-valine synthetase.
L-delta-(alpha-aminoadipoyl)-L-cysteinyl-D-valine synthetase.
Reaction catalysed
3 ATP + H2O + L-2-aminoadipate + L-cysteine + L-valine <=> 3 AMP + 3 diphosphate + 3 H(+) + N-[(5S)-5-amino-5-carboxypentanoyl]-L-cysteinyl-D-valine
Comment(s)
  • The enzyme contains 4'-phosphopantetheine, which may be involved in the mechanism of the reaction.
  • Forms part of the penicillin biosynthesis pathway.
Cross-references
BRENDA6.3.2.26
EC2PDB6.3.2.26
ExplorEnz6.3.2.26
PRIAM enzyme-specific profiles6.3.2.26
KEGG Ligand Database for Enzyme Nomenclature6.3.2.26
IUBMB Enzyme Nomenclature6.3.2.26
IntEnz6.3.2.26
MEDLINEFind literature relating to 6.3.2.26
MetaCyc6.3.2.26
Rhea expert-curated reactions6.3.2.26
UniProtKB/Swiss-Prot
P25464, ACVA_ACRCH;  P27742, ACVA_EMENI;  P19787, ACVA_PENCH;  
B6HLU1, ACVA_PENRW;  P27743, ACVS_AMYLA;  Q01757, ACVS_STRCL;  

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