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ENZYME entry: EC 6.3.2.26

Accepted Name
N-(5-amino-5-carboxypentanoyl)-L-cysteinyl-D-valine synthase.
Alternative Name(s)
ACV synthetase.
L-alpha-aminoadipyl-cysteinyl-valine synthetase.
L-delta-(alpha-aminoadipoyl)-L-cysteinyl-D-valine synthetase.
Reaction catalysed
L-2-aminohexanedioate + L-cysteine + L-valine + 3 ATP + H(2)O <=> N-(L-5-amino-5-carboxypentanoyl)-L-cysteinyl-D-valine + 3 AMP + 3 diphosphate
Cofactor(s)
Mg(2+).
Comment(s)
  • The enzyme contains 4'-phosphopantetheine, which may be involved in the mechanism of the reaction.
  • Forms part of the penicillin biosynthesis pathway.
Cross-references
PROSITEPDOC00427
BRENDA6.3.2.26
EC2PDB6.3.2.26
ExplorEnz6.3.2.26
PRIAM enzyme-specific profiles6.3.2.26
KEGG Ligand Database for Enzyme Nomenclature6.3.2.26
IUBMB Enzyme Nomenclature6.3.2.26
IntEnz6.3.2.26
MEDLINEFind literature relating to 6.3.2.26
MetaCyc6.3.2.26
UniProtKB/Swiss-Prot
P19787, ACVS1_PENCH;  P26046, ACVS2_PENCH;  P25464, ACVS_ACRCH;  
P27743, ACVS_AMYLA;  P27742, ACVS_EMENI;  Q01757, ACVS_STRCL;  

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