Home  |  Contact
Due to work on this service, it may not be fully operational on Wednesday March 20 between 1.30 pm and 2.30 pm CEST. Apologies for the inconvenience.

A new class EC 7, Translocases, has been added to the EC list. It will be part of ENZYME from release 2018_10. Read more about EC 7 here.

ENZYME entry: EC

Accepted Name
4-phosphopantoate--beta-alanine ligase.
Alternative Name(s)
Phosphopantothenate synthetase.
Reaction catalysed
ATP + (R)-4-phosphopantoate + beta-alanine <=> AMP + diphosphate + (R)-4'-phosphopantothenate
  • The conversion of (R)-pantoate to (R)-4'-phosphopantothenate is part of the pathway leading to biosynthesis of 4'-phosphopantetheine, an essential cofactor of coenzyme A and acyl-carrier protein.
  • In bacteria and eukaryotes this conversion is performed by condensation with beta-alanine, followed by phosphorylation (EC and EC, respectively).
  • In archaea the order of these two steps is reversed, and phosphorylation precedes condensation with beta-alanine.
  • The two archaeal enzymes that catalyze this conversion are EC and this enzyme.
PRIAM enzyme-specific profiles6.3.2.36
KEGG Ligand Database for Enzyme Nomenclature6.3.2.36
IUBMB Enzyme Nomenclature6.3.2.36
MEDLINEFind literature relating to

View entry in original ENZYME format
View entry in raw text format (no links)
All UniProtKB/Swiss-Prot entries referenced in this entry, with possibility to download in different formats, align etc.
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 6.3.2.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 6.3.-.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 6.-.-.-