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ENZYME entry: EC 6.3.2.36

Accepted Name
4-phosphopantoate--beta-alanine ligase.
Alternative Name(s)
Phosphopantothenate synthetase.
Reaction catalysed
ATP + (R)-4-phosphopantoate + beta-alanine <=> AMP + diphosphate + (R)-4'-phosphopantothenate
Comment(s)
  • The conversion of (R)-pantoate to (R)-4'-phosphopantothenate is part of the pathway leading to biosynthesis of 4'-phosphopantetheine, an essential cofactor of coenzyme A and acyl-carrier protein.
  • In bacteria and eukaryotes this conversion is performed by condensation with beta-alanine, followed by phosphorylation (EC 6.3.2.1 and EC 2.7.1.33, respectively).
  • In archaea the order of these two steps is reversed, and phosphorylation precedes condensation with beta-alanine.
  • The two archaeal enzymes that catalyze this conversion are EC 2.7.1.169 and this enzyme.
Cross-references
BRENDA6.3.2.36
EC2PDB6.3.2.36
ExplorEnz6.3.2.36
PRIAM enzyme-specific profiles6.3.2.36
KEGG Ligand Database for Enzyme Nomenclature6.3.2.36
IUBMB Enzyme Nomenclature6.3.2.36
IntEnz6.3.2.36
MEDLINEFind literature relating to 6.3.2.36
MetaCyc6.3.2.36
Rhea expert-curated reactions6.3.2.36
UniProtKB/Swiss-Prot
Q2FUA9, PPS_METHJ;  Q57662, PPS_METJA;  Q8PUQ1, PPS_METMA;  
Q5JIZ8, PPS_THEKO;  B6YXQ1, PPS_THEON;  

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