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ENZYME entry: EC 6.3.2.39

Accepted Name
aerobactin synthase.
Reaction catalysed
ATP + N(2)-citryl-N(6)-acetyl-N(6)-hydroxy-L-lysine + N(6)-acetyl-N(6)-hydroxy-L-lysine <=> aerobactin + AMP + diphosphate + H(+)
Comment(s)
  • Requires Mg(2+).
  • The enzyme is involved in the biosynthesis of aerobactin, a dihydroxamate siderophore.
  • It belongs to a class of siderophore synthases known as type C nonribosomal peptide synthase-independent synthases (NIS).
  • Type C enzymes are responsible for the formation of amide or ester bonds between a variety of substrates and a prochiral carboxyl group of a citrate molecule that is already linked to a different moiety at its other prochiral carboxyl group.
  • The enzyme is believed to form an adenylate intermediate prior to ligation.
  • Formerly EC 6.3.2.27.
Cross-references
BRENDA6.3.2.39
EC2PDB6.3.2.39
ExplorEnz6.3.2.39
PRIAM enzyme-specific profiles6.3.2.39
KEGG Ligand Database for Enzyme Nomenclature6.3.2.39
IUBMB Enzyme Nomenclature6.3.2.39
IntEnz6.3.2.39
MEDLINEFind literature relating to 6.3.2.39
MetaCyc6.3.2.39
Rhea expert-curated reactions6.3.2.39
UniProtKB/Swiss-Prot
Q47318, IUCC_ECOLX;  Q76BS5, IUCC_VIBMI;  

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