ENZYME entry: EC 6.3.2.39
| Accepted Name |
|---|
| Aerobactin synthase.
|
| Reaction catalysed |
|---|
| ATP + N(2)-citryl-N(6)-acetyl-N(6)-hydroxy-L-lysine + N(6)-acetyl-N(6)-hydroxy-L-lysine <=> AMP + diphosphate + aerobactin |
| Cofactor(s) |
|---|
| Mg(2+).
|
| Comment(s) |
|---|
- Requires Mg(2+).
- The enzyme is involved in the biosynthesis of aerobactin,
a dihydroxamate siderophore.
- It belongs to a class of siderophore synthases known as type
C nonribosomal peptide synthase-independent synthases (NIS).
- Type C enzymes are responsible for the formation of amide or ester
bonds between a variety of substrates and a prochiral carboxyl group
of a citrate molecule that is already linked to a different moiety at
its other prochiral carboxyl group.
- The enzyme is believed to form an adenylate intermediate prior to
ligation.
|
| Cross-references |
|---|
| BRENDA | 6.3.2.39 |
| EC2PDB | 6.3.2.39 |
| ExplorEnz | 6.3.2.39 |
| PRIAM enzyme-specific profiles | 6.3.2.39 |
| KEGG Ligand Database for Enzyme Nomenclature | 6.3.2.39 |
| IUBMB Enzyme Nomenclature | 6.3.2.39 |
| IntEnz | 6.3.2.39 |
| MEDLINE | Find literature relating to 6.3.2.39 |
| MetaCyc | 6.3.2.39 |
| UniProtKB/Swiss-Prot |
|
View entry in original ENZYME format
View entry in raw text format (no links)
All
ENZYME /
UniProtKB/Swiss-Prot entries corresponding to 6.3.2.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 6.3.-.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 6.-.-.-