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ENZYME

ENZYME entry: EC 6.3.2.43

Accepted Name
[amino-group carrier protein]--L-2-aminoadipate ligase
Alternative Name(s)
AAA--LysW ligase
alpha-aminoadipate-lysW ligase
Reaction catalysed
[amino-group carrier protein]-C-terminal-L-glutamate + ATP + L-2-aminoadipate = [amino-group carrier protein]-C-terminal-N-(1,4-dicarboxybutan-1-yl)-L-glutamine + ADP + H(+) + phosphate
Comment(s)
  • The enzymes from the thermophilic bacterium Thermus thermophilus and the thermophilic archaea Sulfolobus acidocaldarius and Sulfolobus tokodaii protect the amino group of L-2-aminoadipate by conjugation to the carrier protein LysW.
  • This reaction is part of the lysine biosynthesis pathway in these organisms.
  • Formerly EC 6.3.2.n4.
Cross-references
BRENDA6.3.2.43
EC2PDB6.3.2.43
ExplorEnz6.3.2.43
PRIAM enzyme-specific profiles6.3.2.43
KEGG Ligand Database for Enzyme Nomenclature6.3.2.43
IUBMB Enzyme Nomenclature6.3.2.43
IntEnz6.3.2.43
MEDLINEFind literature relating to 6.3.2.43
MetaCyc6.3.2.43
Rhea expert-curated reactions6.3.2.43
UniProtKB/Swiss-Prot
Q7SI95, LYSX_SACS2Q4JAP9, LYSX_SULACQ976J9, LYSX_SULTO
Q5SH23, LYSX_THET8

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