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ENZYME entry: EC 6.3.2.53

Accepted Name
UDP-N-acetylmuramoyl-L-alanine--L-glutamate ligase.
Alternative Name(s)
UDP-MurNAc-L-Ala-L-Glu synthetase.
UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-L-glutamate synthetase.
Reaction catalysed
ATP + UDP-N-acetyl-alpha-D-muramoyl-L-alanine + L-glutamate <=> ADP + phosphate + UDP-N-acetyl-alpha-D-muramoyl-L-alanyl-L-glutamate
Comment(s)
  • The enzyme, characterized from the bacterium Xanthomonas oryzae, catalyzes the ligation of a terminal L-glutamate to UDP-N-acetyl- alpha-D-muramoyl-L-alanine.
  • The combined activity of this enzyme and EC 5.1.1.23 provides an alternative route for incorporating D-glutamate into peptidoglycan, replacing the more common combination of EC 5.1.1.3 and EC 6.3.2.9.
Cross-references
BRENDA6.3.2.53
EC2PDB6.3.2.53
ExplorEnz6.3.2.53
PRIAM enzyme-specific profiles6.3.2.53
KEGG Ligand Database for Enzyme Nomenclature6.3.2.53
IUBMB Enzyme Nomenclature6.3.2.53
IntEnz6.3.2.53
MEDLINEFind literature relating to 6.3.2.53
MetaCyc6.3.2.53
Rhea expert-curated reactions6.3.2.53
UniProtKB/Swiss-Prot
C4RJF7, MURD2_MICS3;  A4X981, MURD2_SALTO;  Q8PII9, MURD2_XANAC;  
Q3BR29, MURD2_XANC5;  Q4UWX9, MURD2_XANC8;  Q8P775, MURD2_XANCP;  
Q2P5V2, MURD2_XANOM;  Q5H2Y1, MURD2_XANOR;  Q9PEB0, MURD2_XYLFA;  
Q87EA7, MURD2_XYLFT;  

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