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ENZYME entry: EC 6.3.2.54

Accepted Name
L-2,3-diaminopropanoate--citrate ligase.
Alternative Name(s)
2-((L-alanin-3-ylcarbamoyl)methyl)-2-hydroxybutanedioate synthtase.
Reaction catalysed
ATP + L-2,3-diaminopropanoate + citrate <=> AMP + diphosphate + 2-((L-alanin-3-ylcarbamoyl)methyl)-2-hydroxybutanedioate
Comment(s)
  • Requires Mg(2+).
  • The enzyme, characterized from the bacterium Staphylococcus aureus, is involved in the biosynthesis of the siderophore staphyloferrin B.
  • It belongs to a class of siderophore synthases known as type A nonribosomal peptide synthase-independent synthases (NIS).
  • Type A NIS enzymes are responsible for the formation of amide or ester bonds between polyamines or amino alcohols and a prochiral carboxyl group of citrate.
  • The enzyme forms a citrate adenylate intermediate prior to ligation.
Cross-references
BRENDA6.3.2.54
EC2PDB6.3.2.54
ExplorEnz6.3.2.54
PRIAM enzyme-specific profiles6.3.2.54
KEGG Ligand Database for Enzyme Nomenclature6.3.2.54
IUBMB Enzyme Nomenclature6.3.2.54
IntEnz6.3.2.54
MEDLINEFind literature relating to 6.3.2.54
MetaCyc6.3.2.54
Rhea expert-curated reactions6.3.2.54
UniProtKB/Swiss-Prot
Q2G1M9, SBNE_STAA8

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