ENZYME entry: EC 6.3.4.16
Accepted Name |
Carbamoyl-phosphate synthase (ammonia).
|
Alternative Name(s) |
Carbamoyl-phosphate synthetase (ammonia). |
Carbamoyl-phosphate synthetase I. |
Carbamoylphosphate synthase (ammonia). |
Carbamoylphosphate synthetase (ammonia). |
Carbon-dioxide--ammonia ligase. |
CPS I. |
Reaction catalysed |
2 ATP + NH(3) + HCO(3)(-) <=> 2 ADP + phosphate + carbamoyl phosphate |
Comment(s) |
- The enzyme catalyzes the first committed step in the urea cycle.
- The reaction proceeds via three separate chemical reactions:
phosphorylation of hydrogencarbonate to carboxyphosphate; a
nucleophilic attack of ammonia on carboxyphosphate yielding
carbamate; and the phosphorylation of carbamate forming carbamoyl
phosphate.
- Two moles of ATP are utilized for the synthesis of one molecule of
carbamyl phosphate, making the reaction essentially irreversible.
- The enzyme requires the allosteric activator N-acetyl-L-glutamate.
- Cf. EC 6.3.5.5.
- Formerly EC 2.7.2.5.
|
Cross-references |
PROSITE | PDOC00676 |
BRENDA | 6.3.4.16 |
EC2PDB | 6.3.4.16 |
ExplorEnz | 6.3.4.16 |
PRIAM enzyme-specific profiles | 6.3.4.16 |
KEGG Ligand Database for Enzyme Nomenclature | 6.3.4.16 |
IUBMB Enzyme Nomenclature | 6.3.4.16 |
IntEnz | 6.3.4.16 |
MEDLINE | Find literature relating to 6.3.4.16 |
MetaCyc | 6.3.4.16 |
Rhea expert-curated reactions | 6.3.4.16 |
UniProtKB/Swiss-Prot |
|
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