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ENZYME

ENZYME entry: EC 6.3.4.21

Accepted Name
nicotinate phosphoribosyltransferase
Alternative Name(s)
niacin ribonucleotidase
nicotinic acid mononucleotide glycohydrolase
nicotinic acid mononucleotide pyrophosphorylase
nicotinic acid phosphoribosyltransferase
Reaction catalysed
5-phospho-alpha-D-ribose 1-diphosphate + ATP + H2O + nicotinate <=> ADP + diphosphate + nicotinate beta-D-ribonucleotide + phosphate
Comment(s)
  • The enzyme, which is involved in pyridine nucleotide recycling, can form beta-nicotinate D-ribonucleotide and diphosphate from nicotinate and 5-phospho-alpha-D-ribose 1-diphosphate (PRPP) in the absence of ATP.
  • However, when ATP is available the enzyme is phosphorylated resulting in a much lower Km for nicotinate.
  • The phospho-enzyme is hydrolyzed during the transferase reaction, regenerating the low affinity form.
  • The presence of ATP shifts the products/substrates equilibrium from 0.67 to 1100.
  • Formerly EC 2.4.2.11.
Cross-references
BRENDA6.3.4.21
EC2PDB6.3.4.21
ExplorEnz6.3.4.21
PRIAM enzyme-specific profiles6.3.4.21
KEGG Ligand Database for Enzyme Nomenclature6.3.4.21
IUBMB Enzyme Nomenclature6.3.4.21
IntEnz6.3.4.21
MEDLINEFind literature relating to 6.3.4.21
MetaCyc6.3.4.21
Rhea expert-curated reactions6.3.4.21
UniProtKB/Swiss-Prot
Q8RWM2, NPRT1_ARATHQ84WV8, NPRT2_ARATHQ9UTK3, NPT1_SCHPO
P39683, NPT1_YEASTP9WJI8, PNCB1_MYCTOP9WJI9, PNCB1_MYCTU
Q9HUP4, PNCB1_PSEAEP9WJI6, PNCB2_MYCTOP9WJI7, PNCB2_MYCTU
Q9HW26, PNCB2_PSEAEQ6F6W1, PNCB_ACIADB2I1P1, PNCB_ACIBC
A3MA25, PNCB_ACIBTB9MHC7, PNCB_ACIETA1W8S8, PNCB_ACISJ
Q8UIS9, PNCB_AGRFCB9J6S5, PNCB_AGRRKB9JYR4, PNCB_AGRVS
O32090, PNCB_BACSUA1UUA2, PNCB_BARBKQ6G5H6, PNCB_BARHE
Q6G0X7, PNCB_BARQUA9ILN1, PNCB_BART1Q7WCZ8, PNCB_BORBR
Q7W5G3, PNCB_BORPAA9IIC5, PNCB_BORPDQ7VTF7, PNCB_BORPE
A5PK51, PNCB_BOVINQ89SS3, PNCB_BRADUA5E8V7, PNCB_BRASB
A4YK54, PNCB_BRASOB2S8A9, PNCB_BRUA1Q2YNV6, PNCB_BRUA2
A6WV52, PNCB_BRUA4Q57FQ9, PNCB_BRUABA9M757, PNCB_BRUC2
C0RGH3, PNCB_BRUMBQ8YEP2, PNCB_BRUMEB0CIM5, PNCB_BRUSI
Q8G340, PNCB_BRUSUB8D9E6, PNCB_BUCA5P57442, PNCB_BUCAI
Q8K9I6, PNCB_BUCAPB8D7P8, PNCB_BUCATB1YVJ0, PNCB_BURA4
A0K5S6, PNCB_BURCHQ0BH38, PNCB_BURCMQ62LW1, PNCB_BURMA
B1JY80, PNCB_BURO0Q1BXX4, PNCB_BURO1Q63S63, PNCB_BURPS
A4JCM8, PNCB_BURVGQ95XX1, PNCB_CAEELQ11HJ2, PNCB_CHESB
Q1QZ10, PNCB_CHRSDQ7NSK2, PNCB_CHRVOA8AIE5, PNCB_CITK8
A7MEW8, PNCB_CROS8Q0K8J9, PNCB_CUPNHQ6P3H4, PNCB_DANRE
C0QFM5, PNCB_DESAHQ55G10, PNCB_DICDIQ9VQX4, PNCB_DROME
A7ZK22, PNCB_ECO24B7UN17, PNCB_ECO27B7MHP0, PNCB_ECO45
B7LE31, PNCB_ECO55Q8XDE8, PNCB_ECO57B5YT65, PNCB_ECO5E
B7NM43, PNCB_ECO7IB7MS49, PNCB_ECO81B7M860, PNCB_ECO8A
C4ZQ57, PNCB_ECOBWB1X8N5, PNCB_ECODHA7ZYN4, PNCB_ECOHS
Q8FJ98, PNCB_ECOL6P18133, PNCB_ECOLIB7N398, PNCB_ECOLU
B6I904, PNCB_ECOSEB1LJT2, PNCB_ECOSMC5BD56, PNCB_EDWI9
A4W8V0, PNCB_ENT38B2VC92, PNCB_ERWT9B7LNU8, PNCB_ESCF3
A4G168, PNCB_HERARQ6XQN6, PNCB_HUMANQ8TMW6, PNCB_METAC
Q12Z05, PNCB_METBUQ8PSJ3, PNCB_METMAQ8CC86, PNCB_MOUSE
Q5F836, PNCB_NEIG1B4RL23, PNCB_NEIG2A9M0T9, PNCB_NEIM0
Q9JTM8, PNCB_NEIMAQ9JYM9, PNCB_NEIMBQ1QI14, PNCB_NITHX
Q6D454, PNCB_PECASC6DFB8, PNCB_PECCPQ7N621, PNCB_PHOLL
Q6LRA6, PNCB_PHOPRQ128P8, PNCB_POLSJB4EVC0, PNCB_PROMH
Q48NY1, PNCB_PSE14A4XS60, PNCB_PSEMYA5W9Q6, PNCB_PSEP1
Q3KIW4, PNCB_PSEPFB0KKX3, PNCB_PSEPGQ88DF7, PNCB_PSEPK
Q87VL5, PNCB_PSESMQ4ZYV7, PNCB_PSEU2A1SVJ9, PNCB_PSYIN
B2U8V2, PNCB_RALPJQ8Y0L2, PNCB_RALSOQ6XQN1, PNCB_RAT
B3PXL5, PNCB_RHIE6Q2KDT0, PNCB_RHIECQ98D24, PNCB_RHILO
B5ZWU4, PNCB_RHILWQ92S49, PNCB_RHIMEB5F1U0, PNCB_SALA4
A9MHU8, PNCB_SALARQ57QZ3, PNCB_SALCHB5FQ81, PNCB_SALDC
B5QZD8, PNCB_SALEPB5R8M1, PNCB_SALG2B4TDS5, PNCB_SALHS
B4T172, PNCB_SALNSQ5PGD8, PNCB_SALPAA9N6Y6, PNCB_SALPB
C0PXX2, PNCB_SALPCB5BBM4, PNCB_SALPKB4TRW6, PNCB_SALSV
Q8Z7Y9, PNCB_SALTIP22253, PNCB_SALTYA8GCJ6, PNCB_SERP5
B2TUE4, PNCB_SHIB3Q31YR6, PNCB_SHIBSQ32E52, PNCB_SHIDS
Q83LN3, PNCB_SHIFLQ3Z3I9, PNCB_SHISSC3MFW1, PNCB_SINFN
A6U5X9, PNCB_SINMWQ2NU84, PNCB_SODGMQ9HJ28, PNCB_THEAC
A1WJL0, PNCB_VEREIA7N4I5, PNCB_VIBC1A5F1F1, PNCB_VIBC3
Q9KN67, PNCB_VIBCHC3LUC2, PNCB_VIBCMQ87JE4, PNCB_VIBPA
Q8DA38, PNCB_VIBVUQ7MK41, PNCB_VIBVYQ8PGU5, PNCB_XANAC
Q3BPD5, PNCB_XANC5Q4UQS8, PNCB_XANC8B0RVE9, PNCB_XANCB
Q8PCP3, PNCB_XANCPQ9PED1, PNCB_XYLFAQ87EC4, PNCB_XYLFT
A1JMP2, PNCB_YERE8A7FJU4, PNCB_YERP3Q8ZG93, PNCB_YERPE
Q66CG6, PNCB_YERPS

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All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 6.3.4.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 6.3.-.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 6.-.-.-