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ENZYME

ENZYME entry: EC 6.3.4.23

PURL: https://purl.expasy.org/enzyme/EC/6.3.4.23
Accepted Name
formate--phosphoribosylaminoimidazolecarboxamide ligase
Alternative Name(s)
5-formaminoimidazole-4-carboxamide-1-beta-D-ribofuranosyl 5'-monophosphate synthetase
5-formaminoimidazole-4-carboxamide ribonucleotide synthetase
Reaction catalysed
5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide + formate + ATP = 5-formamido-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide + ADP + phosphate
Comment(s)
  • This archaeal enzyme, characterized from the methanogen Methanocaldococcus jannaschii, catalyzes a step in the synthesis of purine nucleotides.
  • It differs from the orthologous bacterial/eukaryotic enzymes, which utilize 10-formyltetrahydrofolate rather than formate and ATP. cf. EC 2.1.2.3.
Cross-references
BRENDA6.3.4.23
EC2PDB6.3.4.23
ExplorEnz6.3.4.23
KEGG Ligand Database for Enzyme Nomenclature6.3.4.23
IUBMB Enzyme Nomenclature6.3.4.23
MEDLINEFind literature relating to 6.3.4.23
MetaCyc6.3.4.23
Rhea expert-curated reactions6.3.4.23
UniProtKB/Swiss-Prot
Q8PWT3, PURP1_METMAQ8PT10, PURP2_METMAO30123, PURP_ARCFU
A8M9J5, PURP_CALMQA0RU67, PURP_CENSYA8A9M3, PURP_IGNH4
B1L3X7, PURP_KORCOA6UWN1, PURP_META3Q8TU67, PURP_METAC
Q0W2C6, PURP_METARQ46CU6, PURP_METBFQ12VJ6, PURP_METBU
Q57600, PURP_METJAQ8TXS2, PURP_METKAA4FWE6, PURP_METM5
A9A9U0, PURP_METM6A6VGV9, PURP_METM7Q6LXH8, PURP_METMP
A5UKI3, PURP_METS3A4YCP2, PURP_METS5Q2NHH7, PURP_METST
O27269, PURP_METTHA0B5K9, PURP_METTPP14027, PURP_METVS
A9A1D3, PURP_NITMSQ9V0I8, PURP_PYRABQ8ZYV1, PURP_PYRAE
A4WN42, PURP_PYRARA3MTB5, PURP_PYRCJQ8U0R7, PURP_PYRFU
O59073, PURP_PYRHOA1RQP5, PURP_PYRILB1YBN2, PURP_PYRNV
Q980P7, PURP_SACS2Q4JAU3, PURP_SULACQ975Y9, PURP_SULTO
Q5JFL8, PURP_THEKO

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