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ENZYME entry: EC 6.3.5.13

Accepted Name
lipid II isoglutaminyl synthase (glutamine-hydrolyzing).
Reaction catalysed
ATP + beta-D-GlcNAc-(1->4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)-di-trans,octa-cis-undecaprenyl diphosphate + H2O + L-glutamine <=> ADP + beta-D-GlcNAc-(1->4)-Mur2Ac(oyl-L-Ala-D-isoglutaminyl-L-Lys-D-Ala-D-Ala)-di-trans,octa-cis-undecaprenyl diphosphate + H(+) + L-glutamate + phosphate
Comment(s)
  • The enzyme complex, found in Gram-positive bacteria, consists of two subunits.
  • A glutaminase subunit (cf. EC 3.5.1.2) produces an ammonia molecule that is channeled to a ligase subunit, which adds it to the activated D-glutamate residue of lipid II, converting it to an isoglutamine residue.
Cross-references
BRENDA6.3.5.13
EC2PDB6.3.5.13
ExplorEnz6.3.5.13
PRIAM enzyme-specific profiles6.3.5.13
KEGG Ligand Database for Enzyme Nomenclature6.3.5.13
IUBMB Enzyme Nomenclature6.3.5.13
IntEnz6.3.5.13
MEDLINEFind literature relating to 6.3.5.13
MetaCyc6.3.5.13
Rhea expert-curated reactions6.3.5.13
UniProtKB/Swiss-Prot
A0A0H2WZ38, GATD_STAAC;  A0A0H3JN63, GATD_STAAN;  Q8DNZ8, GATD_STRR6;  
A0A0H2WZQ7, MURT_STAAC;  A0A0H3JUU7, MURT_STAAN;  Q8DNZ9, MURT_STRR6;  

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