ENZYME entry: EC 6.3.5.13
Accepted Name |
lipid II isoglutaminyl synthase (glutamine-hydrolyzing).
|
Reaction catalysed |
ATP + beta-D-GlcNAc-(1->4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)-di-trans,octa-cis-undecaprenyl diphosphate + H2O + L-glutamine <=> ADP + beta-D-GlcNAc-(1->4)-Mur2Ac(oyl-L-Ala-D-isoglutaminyl-L-Lys-D-Ala-D-Ala)-di-trans,octa-cis-undecaprenyl diphosphate + H(+) + L-glutamate + phosphate |
Comment(s) |
- The enzyme complex, found in Gram-positive bacteria, consists of two
subunits.
- A glutaminase subunit (cf. EC 3.5.1.2) produces an ammonia molecule
that is channeled to a ligase subunit, which adds it to the activated
D-glutamate residue of lipid II, converting it to an isoglutamine
residue.
|
Cross-references |
BRENDA | 6.3.5.13 |
EC2PDB | 6.3.5.13 |
ExplorEnz | 6.3.5.13 |
PRIAM enzyme-specific profiles | 6.3.5.13 |
KEGG Ligand Database for Enzyme Nomenclature | 6.3.5.13 |
IUBMB Enzyme Nomenclature | 6.3.5.13 |
IntEnz | 6.3.5.13 |
MEDLINE | Find literature relating to 6.3.5.13 |
MetaCyc | 6.3.5.13 |
Rhea expert-curated reactions | 6.3.5.13 |
UniProtKB/Swiss-Prot |
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