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ENZYME

ENZYME entry: EC 6.3.5.13

PURL: https://purl.expasy.org/enzyme/EC/6.3.5.13
Accepted Name
lipid II isoglutaminyl synthase (glutamine-hydrolyzing)
Reaction catalysed
beta-D-GlcNAc-(1->4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)-di-trans,octa-cis-undecaprenyl diphosphate + L-glutamine + ATP + H2O = beta-D-GlcNAc-(1->4)-Mur2Ac(oyl-L-Ala-D-isoglutaminyl-L-Lys-D-Ala-D-Ala)-di-trans,octa-cis-undecaprenyl diphosphate + L-glutamate + ADP + phosphate + H(+)
Comment(s)
  • The enzyme complex, found in Gram-positive bacteria, consists of two subunits.
  • A glutaminase subunit (cf. EC 3.5.1.2) produces an ammonia molecule that is channeled to a ligase subunit, which adds it to the activated D-glutamate residue of lipid II, converting it to an isoglutamine residue.
Cross-references
BRENDA6.3.5.13
EC2PDB6.3.5.13
ExplorEnz6.3.5.13
KEGG Ligand Database for Enzyme Nomenclature6.3.5.13
IUBMB Enzyme Nomenclature6.3.5.13
MEDLINEFind literature relating to 6.3.5.13
MetaCyc6.3.5.13
Rhea expert-curated reactions6.3.5.13
UniProtKB/Swiss-Prot
A0A0H2WZ38, GATD_STAACA0A0H3JN63, GATD_STAANQ8DNZ8, GATD_STRR6
A0A0H2WZQ7, MURT_STAACA0A0H3JUU7, MURT_STAANQ8DNZ9, MURT_STRR6

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