ENZYME entry: EC 6.3.5.13

Accepted Name

Lipid II isoglutaminyl synthase (glutamine-hydrolyzing).

Reaction catalysed

ATP + beta-D-GlcNAc-(1->4)-Mur2Ac(oyl-L-Ala-gamma-D-Glu-L-Lys-D-Ala-D-Ala)-diphospho-ditrans,octacis-undecaprenol + L-glutamine + H(2)O <=> ADP + phosphate + beta-D-GlcNAc-(1->4)-MurNAc-L-Ala-D-isoglutaminyl-L-Lys-D-Ala-D-Ala-diphospho-ditrans,octacis-undecaprenol + L-glutamate

Comment(s)

The enzyme complex, found in Gram-positive bacteria, consists of two subunits.
A glutaminase subunit (cf. EC 3.5.1.2) produces an ammonia molecule that is channeled to a ligase subunit, which adds it to the activated D-glutamate residue of lipid II, converting it to an isoglutamine residue.

Cross-references

BRENDA

6.3.5.13

EC2PDB

6.3.5.13

ExplorEnz

6.3.5.13

PRIAM enzyme-specific profiles

6.3.5.13

KEGG Ligand Database for Enzyme Nomenclature

6.3.5.13

IUBMB Enzyme Nomenclature

6.3.5.13

IntEnz

6.3.5.13

MEDLINE

Find literature relating to 6.3.5.13

MetaCyc

6.3.5.13

UniProtKB/Swiss-Prot

A0A0H2WZ38, GATD_STAAC;	A0A0H3JN63, GATD_STAAN;	Q8DNZ8, GATD_STRR6;
A0A0H2WZQ7, MURT_STAAC;	A0A0H3JUU7, MURT_STAAN;	Q8DNZ9, MURT_STRR6;

View entry in original ENZYME format
View entry in raw text format (no links)

All UniProtKB/Swiss-Prot entries referenced in this entry, with possibility to download in different formats, align etc.

All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 6.3.5.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 6.3.-.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 6.-.-.-