ENZYME entry: EC 6.4.1.2
Accepted Name |
acetyl-CoA carboxylase.
|
Reaction catalysed |
acetyl-CoA + ATP + hydrogencarbonate <=> ADP + H(+) + malonyl-CoA + phosphate |
Comment(s) |
- This enzyme is a multi-domain polypeptide that catalyzes three
different activities - a biotin carboxyl-carrier protein (BCCP),
a biotin carboxylase that catalyzes the transfer of a carboxyl group
from hydrogencarbonate to the biotin molecule carried by the carrier
protein, and the transfer of the carboxyl group from biotin to
acetyl-CoA, forming malonyl-CoA.
- In some organisms these activities are catalyzed by separate enzymes
(see EC 6.3.4.14 and EC 2.1.3.15).
- The carboxylation of the carrier protein requires ATP, while the
transfer of the carboxyl group to acetyl-CoA does not.
|
Cross-references |
BRENDA | 6.4.1.2 |
EC2PDB | 6.4.1.2 |
ExplorEnz | 6.4.1.2 |
PRIAM enzyme-specific profiles | 6.4.1.2 |
KEGG Ligand Database for Enzyme Nomenclature | 6.4.1.2 |
IUBMB Enzyme Nomenclature | 6.4.1.2 |
IntEnz | 6.4.1.2 |
MEDLINE | Find literature relating to 6.4.1.2 |
MetaCyc | 6.4.1.2 |
Rhea expert-curated reactions | 6.4.1.2 |
UniProtKB/Swiss-Prot |
Q9TTS3, ACACA_BOVIN; | Q13085, ACACA_HUMAN; | Q5SWU9, ACACA_MOUSE; |
P11497, ACACA_RAT; | Q28559, ACACA_SHEEP; | O00763, ACACB_HUMAN; |
E9Q4Z2, ACACB_MOUSE; | P85438, ACAC_CATRO; | P11029, ACAC_CHICK; |
Q54J08, ACAC_DICDI; | P78820, ACAC_SCHPO; | Q00955, ACAC_YEAST; |
Q38970, ACC1_ARATH; | Q8S6N5, ACC1_ORYSJ; | F4I1L3, ACC2_ARATH; |
B9FK36, ACC2_ORYSJ; | A0A4P8DJE6, DMXL1_CRYX8; | B3LM95, HFA1_YEAS1; |
C7GRE4, HFA1_YEAS2; | A6ZMR9, HFA1_YEAS7; | C8ZF72, HFA1_YEAS8; |
P32874, HFA1_YEAST; |
|
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