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ENZYME entry: EC 6.4.1.2

Accepted Name
Acetyl-CoA carboxylase.
Reaction catalysed
ATP + acetyl-CoA + HCO(3)(-) <=> ADP + phosphate + malonyl-CoA
Cofactor(s)
Biotin.
Comment(s)
  • This enzyme is a multi-domain polypeptide that catalyzes three different activities - a biotin carboxyl-carrier protein (BCCP), a biotin carboxylase that catalyzes the transfer of a carboxyl group from hydrogencarbonate to the biotin molecule carried by the carrier protein, and the transfer of the carboxyl group from biotin to acetyl-CoA, forming malonyl-CoA.
  • In some organisms these activities are catalyzed by separate enzymes (see EC 6.3.4.14 and EC 2.1.3.15).
  • The carboxylation of the carrier protein requires ATP, while the transfer of the carboxyl group to acetyl-CoA does not.
Cross-references
PROSITEPDOC00167 ; PDOC00676 ; PDOC50979 ; PDOC50980
BRENDA6.4.1.2
EC2PDB6.4.1.2
ExplorEnz6.4.1.2
PRIAM enzyme-specific profiles6.4.1.2
KEGG Ligand Database for Enzyme Nomenclature6.4.1.2
IUBMB Enzyme Nomenclature6.4.1.2
IntEnz6.4.1.2
MEDLINEFind literature relating to 6.4.1.2
MetaCyc6.4.1.2
Rhea expert-curated reactions6.4.1.2
UniProtKB/Swiss-Prot
Q9TTS3, ACACA_BOVIN;  Q13085, ACACA_HUMAN;  Q5SWU9, ACACA_MOUSE;  
P11497, ACACA_RAT;  Q28559, ACACA_SHEEP;  O00763, ACACB_HUMAN;  
E9Q4Z2, ACACB_MOUSE;  P85438, ACAC_CATRO;  P11029, ACAC_CHICK;  
Q54J08, ACAC_DICDI;  P78820, ACAC_SCHPO;  Q00955, ACAC_YEAST;  
Q38970, ACC1_ARATH;  Q8S6N5, ACC1_ORYSJ;  F4I1L3, ACC2_ARATH;  
B9FK36, ACC2_ORYSJ;  P49787, ACCC1_BACSU;  B9HBA8, ACCC1_POPTR;  
O34544, ACCC2_BACSU;  B9N843, ACCC2_POPTR;  O52058, ACCC_ALLVD;  
O04983, ACCC_ARATH;  Q9KDS9, ACCC_BACHD;  Q8X9B6, ACCC_ECO57;  
P24182, ACCC_ECOLI;  P43873, ACCC_HAEIN;  Q06862, ACCC_NOSS1;  
P84546, ACCC_POPEU;  P37798, ACCC_PSEAE;  B3LM95, HFA1_YEAS1;  
C7GRE4, HFA1_YEAS2;  A6ZMR9, HFA1_YEAS7;  C8ZF72, HFA1_YEAS8;  
P32874, HFA1_YEAST;  

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