A new class EC 7, Translocases, has been added to the EC list. It will be part of ENZYME from release 2018_09. Read more about EC 7 here.
ENZYME entry: EC 6.4.1.2
| Accepted Name |
|---|
| Acetyl-CoA carboxylase.
|
| Reaction catalysed |
|---|
| ATP + acetyl-CoA + HCO(3)(-) <=> ADP + phosphate + malonyl-CoA |
| Cofactor(s) |
|---|
| Biotin.
|
| Comment(s) |
|---|
- This enzyme is a multi-domain polypeptide that catalyzes three
different activities - a biotin carboxyl-carrier protein (BCCP),
a biotin carboxylase that catalyzes the transfer of a carboxyl group
from hydrogencarbonate to the biotin molecule carried by the carrier
protein, and the transfer of the carboxyl group from biotin to
acetyl-CoA, forming malonyl-CoA.
- In some organisms these activities are catalyzed by separate enzymes
(see EC 6.3.4.14 and EC 2.1.3.15).
- The carboxylation of the carrier protein requires ATP, while the
transfer of the carboxyl group to acetyl-CoA does not.
|
| Cross-references |
|---|
| PROSITE | PDOC00167 ; PDOC00676 ; PDOC50979 ; PDOC50980 |
| BRENDA | 6.4.1.2 |
| EC2PDB | 6.4.1.2 |
| ExplorEnz | 6.4.1.2 |
| PRIAM enzyme-specific profiles | 6.4.1.2 |
| KEGG Ligand Database for Enzyme Nomenclature | 6.4.1.2 |
| IUBMB Enzyme Nomenclature | 6.4.1.2 |
| IntEnz | 6.4.1.2 |
| MEDLINE | Find literature relating to 6.4.1.2 |
| MetaCyc | 6.4.1.2 |
| UniProtKB/Swiss-Prot |
| Q9TTS3, ACACA_BOVIN; | Q13085, ACACA_HUMAN; | Q5SWU9, ACACA_MOUSE; |
| P11497, ACACA_RAT; | Q28559, ACACA_SHEEP; | O00763, ACACB_HUMAN; |
| E9Q4Z2, ACACB_MOUSE; | P85438, ACAC_CATRO; | P11029, ACAC_CHICK; |
| Q54J08, ACAC_DICDI; | P78820, ACAC_SCHPO; | Q00955, ACAC_YEAST; |
| Q38970, ACC1_ARATH; | Q8S6N5, ACC1_ORYSJ; | F4I1L3, ACC2_ARATH; |
| B9FK36, ACC2_ORYSJ; | P49787, ACCC1_BACSU; | B9HBA8, ACCC1_POPTR; |
| O34544, ACCC2_BACSU; | B9N843, ACCC2_POPTR; | O52058, ACCC_ALLVD; |
| O04983, ACCC_ARATH; | Q9KDS9, ACCC_BACHD; | Q8X9B6, ACCC_ECO57; |
| P24182, ACCC_ECOLI; | P43873, ACCC_HAEIN; | Q06862, ACCC_NOSS1; |
| P84546, ACCC_POPEU; | P37798, ACCC_PSEAE; | P63406, ACCD_MYCBO; |
| P9WQH8, ACCD_MYCTO; | P9WQH9, ACCD_MYCTU; | B3LM95, HFA1_YEAS1; |
| C7GRE4, HFA1_YEAS2; | A6ZMR9, HFA1_YEAS7; | C8ZF72, HFA1_YEAS8; |
| P32874, HFA1_YEAST; |
|
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