| Accepted Name |
|---|
| acetyl-CoA carboxylase
|
| Reaction catalysed |
|---|
| hydrogencarbonate + acetyl-CoA + ATP = malonyl-CoA + ADP + phosphate + H(+) |
| Comment(s) |
|---|
- This enzyme is a multi-domain polypeptide that catalyzes three
different activities - a biotin carboxyl-carrier protein (BCCP),
a biotin carboxylase that catalyzes the transfer of a carboxyl group
from hydrogencarbonate to the biotin molecule carried by the carrier
protein, and the transfer of the carboxyl group from biotin to
acetyl-CoA, forming malonyl-CoA.
- In some organisms these activities are catalyzed by separate enzymes
(see EC 6.3.4.14 and EC 2.1.3.15).
- The carboxylation of the carrier protein requires ATP, while the
transfer of the carboxyl group to acetyl-CoA does not.
|
| Cross-references |
|---|
| Rhea expert-curated reactions | 6.4.1.2 |
| ExplorEnz | 6.4.1.2 |
| IUBMB Enzyme Nomenclature | 6.4.1.2 |
| UniProtKB/Swiss-Prot |
| Q9TTS3, ACACA_BOVIN | Q13085, ACACA_HUMAN | Q5SWU9, ACACA_MOUSE |
| P11497, ACACA_RAT | Q28559, ACACA_SHEEP | O00763, ACACB_HUMAN |
| E9Q4Z2, ACACB_MOUSE | P85438, ACAC_CATRO | P11029, ACAC_CHICK |
| Q54J08, ACAC_DICDI | P78820, ACAC_SCHPO | Q00955, ACAC_YEAST |
| Q38970, ACC1_ARATH | Q8S6N5, ACC1_ORYSJ | F4I1L3, ACC2_ARATH |
| B9FK36, ACC2_ORYSJ | A0A4P8DJE6, DMXL1_CRYX8 | B3LM95, HFA1_YEAS1 |
| C7GRE4, HFA1_YEAS2 | A6ZMR9, HFA1_YEAS7 | C8ZF72, HFA1_YEAS8 |
| P32874, HFA1_YEAST |
|
| BRENDA | 6.4.1.2 |
| MetaCyc | 6.4.1.2 |
| KEGG Ligand Database for Enzyme Nomenclature | 6.4.1.2 |
| EC2PDB | 6.4.1.2 |
| MEDLINE | Find literature relating to 6.4.1.2 |
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ENZYME /
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