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ENZYME

ENZYME entry: EC 6.4.1.2

Accepted Name
acetyl-CoA carboxylase
Reaction catalysed
acetyl-CoA + ATP + hydrogencarbonate = ADP + H(+) + malonyl-CoA + phosphate
Comment(s)
  • This enzyme is a multi-domain polypeptide that catalyzes three different activities - a biotin carboxyl-carrier protein (BCCP), a biotin carboxylase that catalyzes the transfer of a carboxyl group from hydrogencarbonate to the biotin molecule carried by the carrier protein, and the transfer of the carboxyl group from biotin to acetyl-CoA, forming malonyl-CoA.
  • In some organisms these activities are catalyzed by separate enzymes (see EC 6.3.4.14 and EC 2.1.3.15).
  • The carboxylation of the carrier protein requires ATP, while the transfer of the carboxyl group to acetyl-CoA does not.
Cross-references
BRENDA6.4.1.2
EC2PDB6.4.1.2
ExplorEnz6.4.1.2
PRIAM enzyme-specific profiles6.4.1.2
KEGG Ligand Database for Enzyme Nomenclature6.4.1.2
IUBMB Enzyme Nomenclature6.4.1.2
IntEnz6.4.1.2
MEDLINEFind literature relating to 6.4.1.2
MetaCyc6.4.1.2
Rhea expert-curated reactions6.4.1.2
UniProtKB/Swiss-Prot
Q9TTS3, ACACA_BOVINQ13085, ACACA_HUMANQ5SWU9, ACACA_MOUSE
P11497, ACACA_RATQ28559, ACACA_SHEEPO00763, ACACB_HUMAN
E9Q4Z2, ACACB_MOUSEP85438, ACAC_CATROP11029, ACAC_CHICK
Q54J08, ACAC_DICDIP78820, ACAC_SCHPOQ00955, ACAC_YEAST
Q38970, ACC1_ARATHQ8S6N5, ACC1_ORYSJF4I1L3, ACC2_ARATH
B9FK36, ACC2_ORYSJA0A4P8DJE6, DMXL1_CRYX8B3LM95, HFA1_YEAS1
C7GRE4, HFA1_YEAS2A6ZMR9, HFA1_YEAS7C8ZF72, HFA1_YEAS8
P32874, HFA1_YEAST

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