A new class EC 7, Translocases, has been added to the EC list. It will be part of ENZYME from release 2018_10. Read more about EC 7 here.
ENZYME entry: EC 6.3.4.14
| Accepted Name |
|---|
| Biotin carboxylase.
|
| Reaction catalysed |
|---|
| ATP + [biotin carboxyl-carrier protein]-biotin-N(6)-L-lysine + hydrogencarbonate- <=> ADP + phosphate + [biotin carboxyl-carrier protein]-carboxybiotin-N(6)-L-lysine |
| Comment(s) |
|---|
- This enzyme, part of an acetyl-CoA carboxylase complex, acts on a
biotin carboxyl-carrier protein (BCCP) that has been biotinylated by
EC 6.3.4.15.
- In some organisms the enzyme is part of a multi-domain polypeptide
that also includes the carrier protein (e.g. mycobacteria).
- Yet in other organisms (e.g. mammals) this activity is included in a
single polypeptide that also catalyzes the transfer of the carboxyl
group from biotin to acetyl-CoA (see EC 6.4.1.2).
|
| Cross-references |
|---|
| PROSITE | PDOC50975 |
| BRENDA | 6.3.4.14 |
| EC2PDB | 6.3.4.14 |
| ExplorEnz | 6.3.4.14 |
| PRIAM enzyme-specific profiles | 6.3.4.14 |
| KEGG Ligand Database for Enzyme Nomenclature | 6.3.4.14 |
| IUBMB Enzyme Nomenclature | 6.3.4.14 |
| IntEnz | 6.3.4.14 |
| MEDLINE | Find literature relating to 6.3.4.14 |
| MetaCyc | 6.3.4.14 |
| UniProtKB/Swiss-Prot |
| Q9TTS3, ACACA_BOVIN; | Q13085, ACACA_HUMAN; | Q5SWU9, ACACA_MOUSE; |
| P11497, ACACA_RAT; | Q28559, ACACA_SHEEP; | O00763, ACACB_HUMAN; |
| E9Q4Z2, ACACB_MOUSE; | P11029, ACAC_CHICK; | Q54J08, ACAC_DICDI; |
| P78820, ACAC_SCHPO; | Q00955, ACAC_YEAST; | Q38970, ACC1_ARATH; |
| Q8S6N5, ACC1_ORYSJ; | F4I1L3, ACC2_ARATH; | B9FK36, ACC2_ORYSJ; |
| P49787, ACCC1_BACSU; | B9HBA8, ACCC1_POPTR; | O34544, ACCC2_BACSU; |
| B9N843, ACCC2_POPTR; | O52058, ACCC_ALLVD; | O04983, ACCC_ARATH; |
| Q9KDS9, ACCC_BACHD; | Q8X9B6, ACCC_ECO57; | P24182, ACCC_ECOLI; |
| P43873, ACCC_HAEIN; | Q06862, ACCC_NOSS1; | P84546, ACCC_POPEU; |
| P37798, ACCC_PSEAE; | P0A509, BCCA_MYCBO; | P46392, BCCA_MYCLE; |
| P9WPQ2, BCCA_MYCTO; | P9WPQ3, BCCA_MYCTU; | B3LM95, HFA1_YEAS1; |
| C7GRE4, HFA1_YEAS2; | A6ZMR9, HFA1_YEAS7; | C8ZF72, HFA1_YEAS8; |
| P32874, HFA1_YEAST; | I3R7G3, PCCA_HALMT; |
|
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