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ENZYME entry: EC 6.3.4.14

Accepted Name
Biotin carboxylase.
Reaction catalysed
ATP + [biotin carboxyl-carrier protein]-biotin-N(6)-L-lysine + hydrogencarbonate- <=> ADP + phosphate + [biotin carboxyl-carrier protein]-carboxybiotin-N(6)-L-lysine
Comment(s)
  • This enzyme, part of an acetyl-CoA carboxylase complex, acts on a biotin carboxyl-carrier protein (BCCP) that has been biotinylated by EC 6.3.4.15.
  • In some organisms the enzyme is part of a multi-domain polypeptide that also includes the carrier protein (e.g. mycobacteria).
  • Yet in other organisms (e.g. mammals) this activity is included in a single polypeptide that also catalyzes the transfer of the carboxyl group from biotin to acetyl-CoA (see EC 6.4.1.2).
Cross-references
PROSITEPDOC50975
BRENDA6.3.4.14
EC2PDB6.3.4.14
ExplorEnz6.3.4.14
PRIAM enzyme-specific profiles6.3.4.14
KEGG Ligand Database for Enzyme Nomenclature6.3.4.14
IUBMB Enzyme Nomenclature6.3.4.14
IntEnz6.3.4.14
MEDLINEFind literature relating to 6.3.4.14
MetaCyc6.3.4.14
Rhea expert-curated reactions6.3.4.14
UniProtKB/Swiss-Prot
P11029, ACAC_CHICK;  Q54J08, ACAC_DICDI;  P78820, ACAC_SCHPO;  
Q00955, ACAC_YEAST;  Q38970, ACC1_ARATH;  Q8S6N5, ACC1_ORYSJ;  
F4I1L3, ACC2_ARATH;  B9FK36, ACC2_ORYSJ;  P0A509, ACCA1_MYCBO;  
P9WPQ2, ACCA1_MYCTO;  P9WPQ3, ACCA1_MYCTU;  P46392, ACCA3_MYCLE;  
P96890, ACCA3_MYCTU;  P49787, ACCC1_BACSU;  B9HBA8, ACCC1_POPTR;  
O34544, ACCC2_BACSU;  B9N843, ACCC2_POPTR;  Q9KDS9, ACCC_ALKHC;  
O52058, ACCC_ALLVD;  O04983, ACCC_ARATH;  Q8X9B6, ACCC_ECO57;  
P24182, ACCC_ECOLI;  P43873, ACCC_HAEIN;  Q06862, ACCC_NOSS1;  
P84546, ACCC_POPEU;  P37798, ACCC_PSEAE;  A0A4P8DJE6, DMXL1_CRYX8;  
B3LM95, HFA1_YEAS1;  C7GRE4, HFA1_YEAS2;  A6ZMR9, HFA1_YEAS7;  
C8ZF72, HFA1_YEAS8;  P32874, HFA1_YEAST;  I3R7G3, PCCA_HALMT;  

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