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ENZYME

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ENZYME entry: EC 6.3.4.14

Accepted Name
biotin carboxylase
Reaction catalysed
ATP + hydrogencarbonate + N(6)-biotinyl-L-lysyl-[protein] = ADP + H(+) + N(6)-carboxybiotinyl-L-lysyl-[protein] + phosphate
Comment(s)
  • This enzyme, part of an acetyl-CoA carboxylase complex, acts on a biotin carboxyl-carrier protein (BCCP) that has been biotinylated by EC 6.3.4.15.
  • In some organisms the enzyme is part of a multi-domain polypeptide that also includes the carrier protein (e.g. mycobacteria).
  • Yet in other organisms (e.g. mammals) this activity is included in a single polypeptide that also catalyzes the transfer of the carboxyl group from biotin to acetyl-CoA (see EC 6.4.1.2).
Cross-references
BRENDA6.3.4.14
EC2PDB6.3.4.14
ExplorEnz6.3.4.14
PRIAM enzyme-specific profiles6.3.4.14
KEGG Ligand Database for Enzyme Nomenclature6.3.4.14
IUBMB Enzyme Nomenclature6.3.4.14
IntEnz6.3.4.14
MEDLINEFind literature relating to 6.3.4.14
MetaCyc6.3.4.14
Rhea expert-curated reactions6.3.4.14
UniProtKB/Swiss-Prot
P11029, ACAC_CHICKQ54J08, ACAC_DICDIP78820, ACAC_SCHPO
Q00955, ACAC_YEASTQ38970, ACC1_ARATHQ8S6N5, ACC1_ORYSJ
F4I1L3, ACC2_ARATHB9FK36, ACC2_ORYSJP0A509, ACCA1_MYCBO
P9WPQ2, ACCA1_MYCTOP9WPQ3, ACCA1_MYCTUP46392, ACCA3_MYCLE
P96890, ACCA3_MYCTUP49787, ACCC1_BACSUB9HBA8, ACCC1_POPTR
O34544, ACCC2_BACSUB9N843, ACCC2_POPTRO52058, ACCC_ALLVD
O04983, ACCC_ARATHQ8X9B6, ACCC_ECO57P24182, ACCC_ECOLI
P43873, ACCC_HAEINQ9KDS9, ACCC_HALH5Q06862, ACCC_NOSS1
P84546, ACCC_POPEUP37798, ACCC_PSEAEA0A4P8DJE6, DMXL1_CRYX8
B3LM95, HFA1_YEAS1C7GRE4, HFA1_YEAS2A6ZMR9, HFA1_YEAS7
C8ZF72, HFA1_YEAS8P32874, HFA1_YEASTI3R7G3, PCCA_HALMT

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All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 6.3.4.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 6.3.-.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 6.-.-.-