ENZYME entry: EC 7.6.2.2

PURL: https://purl.expasy.org/enzyme/EC/7.6.2.2

Accepted Name

ABC-type xenobiotic transporter

Alternative Name(s)

ATP phosphohydrolase (steroid-exporting)

MDR protein

multidrug-resistance protein

PDR protein

P-glycoprotein

pleiotropic-drug-resistance protein

steroid-transporting ATPase

xenobiotic-transporting ATPase

Reaction catalysed

ATP + H2O + xenobioticSide 1 = ADP + phosphate + xenobioticSide 2

Comment(s)

An ATP-binding cassette (ABC) type transporter, characterized by the presence of two similar ATP-binding domains/proteins and two integral membrane domains/proteins.
Does not undergo phosphorylation during the transport process.
The enzymes from Gram-positive bacteria and eukaryotic cells export a number of drugs with unusual specificity, covering various groups of unrelated substances while ignoring some that are closely related structurally.
Several distinct enzymes may be present in a single eukaryotic cell.
Many of them also transport glutathione--drug conjugates (see EC 7.6.2.3) while others also show some 'flippase' activity (cf. EC 7.6.2.1).
Formerly EC 3.6.3.44.

Cross-references

BRENDA

7.6.2.2

EC2PDB

7.6.2.2

ExplorEnz

7.6.2.2

KEGG Ligand Database for Enzyme Nomenclature

7.6.2.2

IUBMB Enzyme Nomenclature

7.6.2.2

MEDLINE

Find literature relating to 7.6.2.2

MetaCyc

7.6.2.2

Rhea expert-curated reactions

7.6.2.2

UniProtKB/Swiss-Prot

Q9LYS2, AB10C_ARATH	Q9C8H1, AB11C_ARATH	Q9C8H0, AB12C_ARATH
Q9SKX0, AB13C_ARATH	Q9LZJ5, AB14C_ARATH	Q7FB56, AB15C_ARATH
Q9C8G9, AB1C_ARATH	Q42093, AB2C_ARATH	Q9LK64, AB3C_ARATH
Q7DM58, AB4C_ARATH	Q7GB25, AB5C_ARATH	Q8VZZ4, AB6C_ARATH
Q9LK62, AB7C_ARATH	Q8LGU1, AB8C_ARATH	Q9M1C7, AB9C_ARATH
Q9P7V2, ABC4_SCHPO	Q99758, ABCA3_HUMAN	Q8R420, ABCA3_MOUSE
A0A0G2K1Q8, ABCA3_RAT	Q2M3G0, ABCB5_HUMAN	B5X0E4, ABCB5_MOUSE
Q4GZT4, ABCG2_BOVIN	Q9UNQ0, ABCG2_HUMAN	Q5MB13, ABCG2_MACMU
Q7TMS5, ABCG2_MOUSE	Q8MIB3, ABCG2_PIG	Q80W57, ABCG2_RAT
P0DXG8, DRRA1_STRC4	P0DXU5, DRRA2_STRC4	P0DXU7, DRRA3_STRC4
P32010, DRRA_STRPE	Q9CHL8, LMRA_LACLA	P97046, LMRA_LACLM
P57551, MDLA_BUCAI	Q8K985, MDLA_BUCAP	Q89A97, MDLA_BUCBP
P77265, MDLA_ECOLI	P57552, MDLB_BUCAI	Q8K984, MDLB_BUCAP
Q89A96, MDLB_BUCBP	P0AAG7, MDLB_ECO57	P0AAG6, MDLB_ECOL6
P0AAG5, MDLB_ECOLI	P21447, MDR1A_MOUSE	P06795, MDR1B_MOUSE
P21448, MDR1_CRIGR	P16875, MDR1_ENTH1	P08183, MDR1_HUMAN
Q06034, MDR1_LEIEN	P43245, MDR1_RAT	P21449, MDR2_CRIGR
P16876, MDR3_ENTH1	Q00449, MDR49_DROME	P16877, MDR4_ENTH1
Q00748, MDR65_DROME	P21441, MDR_LEITA	Q7K6A5, MDR_PLAF7
P13568, MDR_PLAFF	Q8HXQ5, MRP1_BOVIN	Q6UR05, MRP1_CANLF
Q5F364, MRP1_CHICK	P33527, MRP1_HUMAN	Q864R9, MRP1_MACFA
O35379, MRP1_MOUSE	Q8CG09, MRP1_RAT	Q92887, MRP2_HUMAN
Q8VI47, MRP2_MOUSE	Q28689, MRP2_RABIT	Q63120, MRP2_RAT
O15438, MRP3_HUMAN	B2RX12, MRP3_MOUSE	O88563, MRP3_RAT
A0AAA9T569, MRP4_BOVIN	O15439, MRP4_HUMAN	E9Q236, MRP4_MOUSE
F1M3J4, MRP4_RAT	O15440, MRP5_HUMAN	Q9R1X5, MRP5_MOUSE
Q9QYM0, MRP5_RAT	Q5T3U5, MRP7_HUMAN	Q8R4P9, MRP7_MOUSE
Q96J66, MRP8_HUMAN	P34712, PGP1_CAEEL	P34713, PGP3_CAEEL
Q9PT60, RBP1A_XENLA	Q15311, RBP1_HUMAN	Q62172, RBP1_MOUSE
Q62796, RBP1_RAT	Q6Q876, SIRA_LEPMC

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