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ENZYME entry: EC 7.6.2.2

Accepted Name
ABC-type xenobiotic transporter.
Alternative Name(s)
ATP phosphohydrolase (steroid-exporting).
MDR protein.
Multidrug-resistance protein.
P-glycoprotein.
PDR protein.
Pleiotropic-drug-resistance protein.
Steroid-transporting ATPase.
Xenobiotic-transporting ATPase.
Reaction catalysed
ATP + H(2)O + xenobiotic(Side 1) <=> ADP + phosphate + xenobiotic(Side 2)
Comment(s)
  • An ATP-binding cassette (ABC) type transporter, characterized by the presence of two similar ATP-binding domains/proteins and two integral membrane domains/proteins.
  • Does not undergo phosphorylation during the transport process.
  • The enzymes from Gram-positive bacteria and eukaryotic cells export a number of drugs with unusual specificity, covering various groups of unrelated substances while ignoring some that are closely related structurally.
  • Several distinct enzymes may be present in a single eukaryotic cell.
  • Many of them also transport glutathione--drug conjugates (see EC 7.6.2.3) while others also show some 'flippase' activity (cf. EC 7.6.2.1).
  • Formerly EC 3.6.3.44.
Cross-references
PROSITEPDOC00185
BRENDA7.6.2.2
EC2PDB7.6.2.2
ExplorEnz7.6.2.2
PRIAM enzyme-specific profiles7.6.2.2
KEGG Ligand Database for Enzyme Nomenclature7.6.2.2
IUBMB Enzyme Nomenclature7.6.2.2
IntEnz7.6.2.2
MEDLINEFind literature relating to 7.6.2.2
MetaCyc7.6.2.2
Rhea expert-curated reactions7.6.2.2
UniProtKB/Swiss-Prot
Q9LYS2, AB10C_ARATH;  Q9C8H1, AB11C_ARATH;  Q9C8H0, AB12C_ARATH;  
Q9SKX0, AB13C_ARATH;  Q9LZJ5, AB14C_ARATH;  Q7FB56, AB15C_ARATH;  
Q9C8G9, AB1C_ARATH;  Q42093, AB2C_ARATH;  Q9LK64, AB3C_ARATH;  
Q7DM58, AB4C_ARATH;  Q7GB25, AB5C_ARATH;  Q8VZZ4, AB6C_ARATH;  
Q9LK62, AB7C_ARATH;  Q8LGU1, AB8C_ARATH;  Q9M1C7, AB9C_ARATH;  
Q9P7V2, ABC4_SCHPO;  Q99758, ABCA3_HUMAN;  Q8R420, ABCA3_MOUSE;  
A0A0G2K1Q8, ABCA3_RAT;  Q2M3G0, ABCB5_HUMAN;  B5X0E4, ABCB5_MOUSE;  
Q4GZT4, ABCG2_BOVIN;  Q9UNQ0, ABCG2_HUMAN;  Q5MB13, ABCG2_MACMU;  
Q7TMS5, ABCG2_MOUSE;  Q8MIB3, ABCG2_PIG;  Q80W57, ABCG2_RAT;  
Q9CHL8, LMRA_LACLA;  P97046, LMRA_LACLM;  P57551, MDLA_BUCAI;  
Q8K985, MDLA_BUCAP;  Q89A97, MDLA_BUCBP;  P77265, MDLA_ECOLI;  
P57552, MDLB_BUCAI;  Q8K984, MDLB_BUCAP;  Q89A96, MDLB_BUCBP;  
P0AAG7, MDLB_ECO57;  P0AAG6, MDLB_ECOL6;  P0AAG5, MDLB_ECOLI;  
P21447, MDR1A_MOUSE;  P06795, MDR1B_MOUSE;  P21448, MDR1_CRIGR;  
P08183, MDR1_HUMAN;  Q06034, MDR1_LEIEN;  P43245, MDR1_RAT;  
P21449, MDR2_CRIGR;  Q00449, MDR49_DROME;  Q00748, MDR65_DROME;  
P21441, MDR_LEITA;  P13568, MDR_PLAFF;  Q8HXQ5, MRP1_BOVIN;  
Q6UR05, MRP1_CANLF;  Q5F364, MRP1_CHICK;  P33527, MRP1_HUMAN;  
Q864R9, MRP1_MACFA;  O35379, MRP1_MOUSE;  Q8CG09, MRP1_RAT;  
Q92887, MRP2_HUMAN;  Q8VI47, MRP2_MOUSE;  Q28689, MRP2_RABIT;  
Q63120, MRP2_RAT;  O15438, MRP3_HUMAN;  B2RX12, MRP3_MOUSE;  
O88563, MRP3_RAT;  O15439, MRP4_HUMAN;  E9Q236, MRP4_MOUSE;  
F1M3J4, MRP4_RAT;  O15440, MRP5_HUMAN;  Q9R1X5, MRP5_MOUSE;  
Q9QYM0, MRP5_RAT;  Q5T3U5, MRP7_HUMAN;  Q8R4P9, MRP7_MOUSE;  
Q96J66, MRP8_HUMAN;  P34712, PGP1_CAEEL;  P34713, PGP3_CAEEL;  
Q9PT60, RBP1A_XENLA;  Q15311, RBP1_HUMAN;  Q62172, RBP1_MOUSE;  
Q62796, RBP1_RAT;  Q6Q876, SIRA_LEPMC;  

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