ENZYME entry: EC 2.1.1.72

PURL: https://purl.expasy.org/enzyme/EC/2.1.1.72

Accepted Name

site-specific DNA-methyltransferase (adenine-specific)

Alternative Name(s)

modification methylase

N-6 adenine-specific DNA methylase

restriction-modification system

Reaction catalysed

a 2'-deoxyadenosine in DNA + S-adenosyl-L-methionine = an N(6)-methyl-2'-deoxyadenosine in DNA + S-adenosyl-L-homocysteine + H(+)

Comment(s)

This is a large group of enzymes, most of which form so-called 'restriction-modification systems', with nucleases that possess similar site specificity (the nucleases are listed as either EC 3.1.21.3, EC 3.1.21.4 and EC 3.1.21.5).
See the REBASE database for a complete list of these enzymes: http://rebase.neb.com/rebase/

Cross-references

Rhea expert-curated reactions

2.1.1.72

ExplorEnz

2.1.1.72

IUBMB Enzyme Nomenclature

2.1.1.72

UniProtKB/Swiss-Prot

B2S9Y5, CCRM_BRUA1	Q2YMK2, CCRM_BRUA2	A6WWI2, CCRM_BRUA4
P0C116, CCRM_BRUAB	A9M916, CCRM_BRUC2	Q8YFS6, CCRM_BRUME
A5VP58, CCRM_BRUO2	B0CKH7, CCRM_BRUSI	Q8G242, CCRM_BRUSU
P0CAW2, CCRM_CAUVC	B8GZ33, CCRM_CAUVN	O30569, CCRM_RHIME
Q09956, DAMT1_CAEEL	P51715, DAM_BPHC1	Q71TL0, DAM_BPP1
Q38156, DAM_BPT1	P21311, DMA7_ECOLX	P12427, DMA_BPT2
P04392, DMA_BPT4	P0AEE9, DMA_ECO57	P0AEE8, DMA_ECOLI
P44431, DMA_HAEIN	P0A292, DMA_SALTI	P0DMP4, DMA_SALTM
P0DMP3, DMA_SALTY	P45454, DMA_SERMA	O33844, DMA_TREPA
A5F520, DMA_VIBC3	P0C6Q8, DMA_VIBCH	O31504, DNMA_BACSU
Q8N3J2, METL4_HUMAN	Q3U034, METL4_MOUSE	P34720, MT1A_MORBO
P34721, MT1B_MORBO	P25240, MT57_ECOLX	P25201, MTA1_ACICA
P58284, MTA1_AZOBR	P22772, MTB3_ANEAE	P33563, MTBB_BACIU
P43423, MTC1_GEOSE	Q01511, MTC1_PBCVC	P42828, MTC1_RHOHA
P31118, MTC2_PBCV1	P10835, MTC3_PBCVC	P04043, MTD21_STREE
P09358, MTD22_STREE	P00472, MTE1_ECOLX	P04393, MTE5_ECOLX
P14827, MTEC_ENTCL	P14871, MTF1_PLAOK	P20590, MTH1_HAEIF
P29538, MTH1_HAEPA	P00473, MTH2_HAEPH	P43871, MTH3_HAEIN
P50193, MTHB_HAEPH	P17744, MTHC_HAEIF	P44414, MTHD_HAEIN
P25238, MTK1_KLEPN	P35516, MTL1_LACLL	P50179, MTL21_LACLC
P50178, MTL22_LACLC	P50190, MTM1_MICAM	Q49400, MTM1_MYCGE
Q50290, MTM1_MYCPN	P23192, MTM2_MORBO	Q58015, MTM3_METJA
Q58724, MTM4_METJA	P43641, MTMU_MYCSP	P24582, MTN3_NEILA
P05103, MTP7_PSEAI	P00474, MTPS_PROST	P14751, MTR1_CERSP
P52284, MTR1_PBCVX	Q53609, MTS1_STRAL	P29347, MTS1_STRSA
P29749, MTT8_THET8	P14385, MTTA_THEAQ	P43422, MTV1_GEOSE
Q03055, MTV1_VIBS3	P96188, MTX1_XANCR	Q9KVZ8, MTX1_XANVA
P0DUF3, PGLX_BACCH	P0DUF9, PGLX_ECOHS	P0DQP1, PGLX_LACCZ
Q8CJM2, PGLX_STRCO	P10484, T1M1_ECOLX	Q57596, T1M1_METJA
Q58617, T1M2_METJA	P75436, T1MD_MYCPN	Q47282, T1ME_ECOLX
Q57168, T1MH_HAEIN	Q60297, T1MH_METJA	P08957, T1MK_ECOLI
Q47163, T1MP_ECOLX	Q89Z59, T1M_BACTN	P07989, T1M_SALPO
P40813, T1M_SALTY	P25239, T257_ECOLX	Q60301, T2RM_METJA
P71366, T3MH_HAEIN	P08763, T3MO_BPP1	P12364, T3MO_ECOLX
P40814, T3MO_SALTY	Q07605, T4BA_HEYCO	P75561, Y108_MYCPN
P75451, Y111_MYCPN	P28638, YHDJ_ECOLI

BRENDA

2.1.1.72

MetaCyc

2.1.1.72

KEGG Ligand Database for Enzyme Nomenclature

2.1.1.72

EC2PDB

2.1.1.72

MEDLINE

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