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ENZYME entry: EC 2.3.1.86

Accepted Name
Fatty-acyl-CoA synthase.
Alternative Name(s)
Yeast fatty acid synthase.
Reaction catalysed
Acetyl-CoA + n malonyl-CoA + 2n NADPH <=> long-chain-acyl-CoA + n CoA + n CO(2) + 2n NADP(+)
Comment(s)
  • The enzyme from yeasts (Ascomycota and Basidiomycota) is a multi- functional protein complex composed of two subunits.
  • One subunit catalyzes the reactions EC 1.1.1.100 and EC 2.3.1.41, while the other subunit catalyzes the reactions of EC 2.3.1.38, EC 2.3.1.39, EC 4.2.1.59, EC 1.3.1.10 and EC 1.1.1.279.
  • The enzyme differs from the animal enzyme (EC 2.3.1.85) in that the enoyl reductase domain requires FMN as a cofactor, and the ultimate product is an acyl-CoA (usually palmitoyl-CoA) instead of a free fatty acid.
Cross-references
BRENDA2.3.1.86
EC2PDB2.3.1.86
ExplorEnz2.3.1.86
PRIAM enzyme-specific profiles2.3.1.86
KEGG Ligand Database for Enzyme Nomenclature2.3.1.86
IUBMB Enzyme Nomenclature2.3.1.86
IntEnz2.3.1.86
MEDLINEFind literature relating to 2.3.1.86
MetaCyc2.3.1.86
UniProtKB/Swiss-Prot
Q8TGA2, AFLA_ASPPU;  Q8TGA1, AFLB_ASPPU;  P34731, FAS1_CANAX;  
Q9UUG0, FAS1_SCHPO;  P34229, FAS1_YARLI;  P07149, FAS1_YEAST;  
P43098, FAS2_CANAX;  G8BAW7, FAS2_CANPC;  P78615, FAS2_EMEND;  
Q5B7V0, FAS2_EMENI;  Q765N2, FAS2_LACKL;  P15368, FAS2_PENPA;  
Q10289, FAS2_SCHPO;  P19097, FAS2_YEAST;  

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All UniProtKB/Swiss-Prot entries referenced in this entry, with possibility to download in different formats, align etc.
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 2.3.1.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 2.3.-.-
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