ENZYME entry: EC

Accepted Name
Fatty-acyl-CoA synthase.
Alternative Name(s)
Yeast fatty acid synthase.
Reaction catalysed
Acetyl-CoA + n malonyl-CoA + 2n NADPH <=> long-chain-acyl-CoA + n CoA + n CO(2) + 2n NADP(+)
  • The enzyme from yeasts (Ascomycota and Basidiomycota) is a multi- functional protein complex composed of two subunits.
  • One subunit catalyzes the reactions EC and EC, while the other subunit catalyzes the reactions of EC, EC, EC, EC and EC
  • The enzyme differs from the animal enzyme (EC in that the enoyl reductase domain requires FMN as a cofactor, and the ultimate product is an acyl-CoA (usually palmitoyl-CoA) instead of a free fatty acid.
PRIAM enzyme-specific profiles2.3.1.86
KEGG Ligand Database for Enzyme Nomenclature2.3.1.86
IUBMB Enzyme Nomenclature2.3.1.86
MEDLINEFind literature relating to
P34731, FAS1_CANAX;  Q9UUG0, FAS1_SCHPO;  P34229, FAS1_YARLI;  
P07149, FAS1_YEAST;  P43098, FAS2_CANAX;  G8BAW7, FAS2_CANPC;  
P78615, FAS2_EMEND;  Q5B7V0, FAS2_EMENI;  Q765N2, FAS2_LACKL;  
P15368, FAS2_PENPA;  Q10289, FAS2_SCHPO;  P19097, FAS2_YEAST;  

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