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A new class EC 7, Translocases, has been added to the EC list. It will be part of ENZYME from release 2018_10. Read more about EC 7 here.

ENZYME entry: EC 1.1.1.170

Accepted Name
3-beta-hydroxysteroid-4-alpha-carboxylate 3-dehydrogenase (decarboxylating).
Alternative Name(s)
3-beta-hydroxy-4-alpha-methylcholestenecarboxylate 3-dehydrogenase (decarboxylating).
3-beta-hydroxy-4-beta-methylcholestenecarboxylate 3-dehydrogenase (decarboxylating).
3-beta-hydroxy-4-beta-methylcholestenoate dehydrogenase.
Sterol 4-alpha-carboxylic decarboxylase.
Sterol-4-alpha-carboxylate 3-dehydrogenase (decarboxylating).
Reaction catalysed
A 3-beta-hydroxysteroid-4-alpha-carboxylate + NAD(P)(+) <=> a 3-oxosteroid + CO(2) + NAD(P)H
Comment(s)
  • The enzyme catalyzes the decarboxylation of the C-4 carbon and the dehydrogenation of a 3-beta hydroxyl at the C-3 carbon of 3-beta- hydroxysteroid-4-alpha-carboxylates.
  • It is involved in zymosterol and cholesterol biosynthesis.
Cross-references
BRENDA1.1.1.170
EC2PDB1.1.1.170
ExplorEnz1.1.1.170
PRIAM enzyme-specific profiles1.1.1.170
KEGG Ligand Database for Enzyme Nomenclature1.1.1.170
IUBMB Enzyme Nomenclature1.1.1.170
IntEnz1.1.1.170
MEDLINEFind literature relating to 1.1.1.170
MetaCyc1.1.1.170
UniProtKB/Swiss-Prot
O43050, ERG26_SCHPO;  P53199, ERG26_YEAST;  Q9FX01, HSDD1_ARATH;  
Q67ZE1, HSDD2_ARATH;  A9X4U2, HSDD3_ARATH;  Q3ZBE9, NSDHL_BOVIN;  
Q54L85, NSDHL_DICDI;  Q15738, NSDHL_HUMAN;  Q9R1J0, NSDHL_MOUSE;  
Q5PPL3, NSDHL_RAT;  

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