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A new class EC 7, Translocases, has been added to the EC list. It will be part of ENZYME from release 2018_10. Read more about EC 7 here.

ENZYME entry: EC 1.1.1.393

Accepted Name
3-beta-hydroxycholanate 3-dehydrogenase (NADP(+)).
Alternative Name(s)
3-beta-hydroxysteroid dehydrogenase.
Reaction catalysed
Isolithocholate + NADP(+) <=> 3-oxo-5-beta-cholan-24-oate + NADPH
Comment(s)
  • This bacterial enzyme is involved, along with EC 1.1.1.52 or EC 1.1.1.392, in the modification of secondary bile acids to form 3-beta-bile acids (also known as iso-bile acids).
  • The enzyme catalyzes the reaction in the reduction direction in vivo.
  • Also acts on related 3-oxo bile acids.
  • Cf. EC 1.1.1.391.
Cross-references
BRENDA1.1.1.393
EC2PDB1.1.1.393
ExplorEnz1.1.1.393
PRIAM enzyme-specific profiles1.1.1.393
KEGG Ligand Database for Enzyme Nomenclature1.1.1.393
IUBMB Enzyme Nomenclature1.1.1.393
IntEnz1.1.1.393
MEDLINEFind literature relating to 1.1.1.393
MetaCyc1.1.1.393
UniProtKB/Swiss-Prot
A7AZH2, 3BHDP_RUMGV

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All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 1.1.1.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 1.1.-.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 1.-.-.-