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ENZYME

ENZYME entry: EC 1.1.1.393

Accepted Name
3beta-hydroxycholanate 3-dehydrogenase (NADP(+))
Alternative Name(s)
3beta-hydroxysteroid dehydrogenase
Reaction catalysed
3-oxo-5beta-cholan-24-oate + H(+) + NADPH <=> isolithocholate + NADP(+)
Comment(s)
  • This bacterial enzyme is involved, along with EC 1.1.1.52 or EC 1.1.1.392, in the modification of secondary bile acids to form 3beta-bile acids (also known as iso-bile acids).
  • The enzyme catalyzes the reaction in the reduction direction in vivo.
  • Also acts on related 3-oxo bile acids. cf. EC 1.1.1.391.
Cross-references
BRENDA1.1.1.393
EC2PDB1.1.1.393
ExplorEnz1.1.1.393
PRIAM enzyme-specific profiles1.1.1.393
KEGG Ligand Database for Enzyme Nomenclature1.1.1.393
IUBMB Enzyme Nomenclature1.1.1.393
IntEnz1.1.1.393
MEDLINEFind literature relating to 1.1.1.393
MetaCyc1.1.1.393
Rhea expert-curated reactions1.1.1.393
UniProtKB/Swiss-Prot
A7AZH2, 3BHDP_RUMGV

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