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ENZYME entry: EC 1.1.1.417

Accepted Name
3-beta-hydroxysteroid-4-beta-carboxylate 3-dehydrogenase (decarboxylating).
Reaction catalysed
A 3-beta-hydroxy-4-beta-carboxy-4-alpha-methylsteroid + NAD(P)(+) <=> a 4-alpha-methyl-3-oxosteroid + NAD(P)H + CO(2) + H(+)
Comment(s)
  • This bacterial enzyme participates in the biosynthesis of bacterial sterols.
  • Together with EC 1.14.13.246 (SdmA) it forms an enzyme system that removes one methyl group from the C-4 position of 4,4-dimethylated steroid molecules.
  • SdmA catalyzes three successive oxidations of the C-4-beta methyl group, turning it into a carboxylate group; SdmB is a bifunctional enzyme that catalyzes two different activities.
  • As EC 1.1.1.417 it catalyzes an oxidative decarboxylation that results in reduction of the 3-beta-hydroxy group at the C-3 carbon to an oxo group.
  • As EC 1.1.1.270, it reduces the 3-oxo group back to a 3-beta- hydroxyl.
  • Since the remaining methyl group at C-4 is in an alpha orientation, it cannot serve as a substrate for a second round of demethylation by this system.
Cross-references
BRENDA1.1.1.417
EC2PDB1.1.1.417
ExplorEnz1.1.1.417
PRIAM enzyme-specific profiles1.1.1.417
KEGG Ligand Database for Enzyme Nomenclature1.1.1.417
IUBMB Enzyme Nomenclature1.1.1.417
IntEnz1.1.1.417
MEDLINEFind literature relating to 1.1.1.417
MetaCyc1.1.1.417

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