ENZYME entry: EC 1.1.1.417
| Accepted Name |
|---|
| 3beta-hydroxysteroid-4beta-carboxylate 3-dehydrogenase (decarboxylating).
|
| Reaction catalysed |
|---|
- a 3beta-hydroxy-4alpha-methylsteroid-4beta-carboxylate + NAD(+) <=> a 4alpha-methyl-3-oxosteroid + CO2 + NADH
- a 3beta-hydroxy-4alpha-methylsteroid-4beta-carboxylate + NADP(+) <=> a 4alpha-methyl-3-oxosteroid + CO2 + NADPH
|
| Comment(s) |
|---|
- This bacterial enzyme participates in the biosynthesis of bacterial
sterols.
- Together with EC 1.14.13.246 (SdmA) it forms an enzyme system that
removes one methyl group from the C-4 position of 4,4-dimethylated
steroid molecules.
- SdmA catalyzes three successive oxidations of the C-4beta methyl
group, turning it into a carboxylate group; SdmB is a bifunctional
enzyme that catalyzes two different activities.
- As EC 1.1.1.417 it catalyzes an oxidative decarboxylation that
results in reduction of the 3beta-hydroxy group at the C-3 carbon to
an oxo group.
- As EC 1.1.1.270, it reduces the 3-oxo group back to a 3beta-hydroxyl.
- Since the remaining methyl group at C-4 is in an alpha orientation,
it cannot serve as a substrate for a second round of demethylation by
this system.
|
| Cross-references |
|---|
| BRENDA | 1.1.1.417 |
| EC2PDB | 1.1.1.417 |
| ExplorEnz | 1.1.1.417 |
| PRIAM enzyme-specific profiles | 1.1.1.417 |
| KEGG Ligand Database for Enzyme Nomenclature | 1.1.1.417 |
| IUBMB Enzyme Nomenclature | 1.1.1.417 |
| IntEnz | 1.1.1.417 |
| MEDLINE | Find literature relating to 1.1.1.417 |
| MetaCyc | 1.1.1.417 |
| Rhea expert-curated reactions | 1.1.1.417 |
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ENZYME /
UniProtKB/Swiss-Prot entries corresponding to 1.1.1.-
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