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ENZYME entry: EC 1.1.3.17

Accepted Name
Choline oxidase.
Reaction catalysed
Choline + 2 O(2) + H(2)O <=> betaine + 2 H(2)O(2)
Cofactor(s)
FAD.
Comment(s)
  • In many bacteria, plants and animals, the osmoprotectant betaine is synthesized using different enzymes to catalyze the conversion of (1) choline into betaine aldehyde and (2) betaine aldehyde into betaine.
  • In plants, the first reaction is catalyzed by EC 1.14.15.7, whereas in animals and many bacteria, it is catalyzed by either EC 1.1.99.1 or EC 1.1.3.17.
  • The enzyme involved in the second step, EC 1.2.1.8, appears to be the same in those plants, animals and bacteria that use two separate enzymes.
Cross-references
BRENDA1.1.3.17
EC2PDB1.1.3.17
ExplorEnz1.1.3.17
PRIAM enzyme-specific profiles1.1.3.17
KEGG Ligand Database for Enzyme Nomenclature1.1.3.17
IUBMB Enzyme Nomenclature1.1.3.17
IntEnz1.1.3.17
MEDLINEFind literature relating to 1.1.3.17
MetaCyc1.1.3.17
Rhea expert-curated reactions1.1.3.17
UniProtKB/Swiss-Prot
P16101, CHOX_ALCSP;  Q7X2H8, CHOX_ARTGO;  

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