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ENZYME entry: EC

Accepted Name
choline monooxygenase.
Reaction catalysed
choline + 2 H(+) + O2 + 2 reduced [2Fe-2S]-[ferredoxin] <=> betaine aldehyde hydrate + H2O + 2 oxidized [2Fe-2S]-[ferredoxin]
  • Catalyzes the first step of glycine betaine synthesis.
  • In many bacteria, plants and animals, the osmoprotectant betaine is synthesized in two steps: (1) choline to betaine aldehyde and (2) betaine aldehyde to betaine.
  • Different enzymes are involved in the first reaction.
  • In plants, the reaction is catalyzed by this enzyme whereas in animals and many bacteria, it is catalyzed by either membrane-bound EC or soluble EC
  • The enzyme involved in the second step, EC, appears to be the same in plants, animals and bacteria.
  • In some bacteria, betaine is synthesized from glycine through the actions of EC and EC
  • Formerly EC
PRIAM enzyme-specific profiles1.14.15.7
KEGG Ligand Database for Enzyme Nomenclature1.14.15.7
IUBMB Enzyme Nomenclature1.14.15.7
MEDLINEFind literature relating to
Rhea expert-curated reactions1.14.15.7
O22553, CHMO_BETVU;  O04121, CHMO_SPIOL;  

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