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ENZYME entry: EC 1.8.7.3

Accepted Name
ferredoxin:CoB-CoM heterodisulfide reductase.
Reaction catalysed
coenzyme B + coenzyme M + 2 oxidized [2Fe-2S]-[ferredoxin] <=> coenzyme M-coenzyme B heterodisulfide + 2 H(+) + 2 reduced [2Fe-2S]-[ferredoxin]
Comment(s)
  • HdrABC is an enzyme complex that is found in most methanogens and catalyzes the reduction of the CoB-CoM heterodisulfide back to CoB and CoM.
  • HdrA contains a FAD cofactor that acts as the entry point for electrons, which are transferred via HdrC to the HdrB catalytic subunit.
  • One form of the enzyme from Methanosarcina acetivorans (HdrA2B2C2) can also catalyze EC 1.8.98.4. cf. EC 1.8.98.5, EC 1.8.98.6, and EC 1.8.98.1.
Cross-references
BRENDA1.8.7.3
EC2PDB1.8.7.3
ExplorEnz1.8.7.3
PRIAM enzyme-specific profiles1.8.7.3
KEGG Ligand Database for Enzyme Nomenclature1.8.7.3
IUBMB Enzyme Nomenclature1.8.7.3
IntEnz1.8.7.3
MEDLINEFind literature relating to 1.8.7.3
MetaCyc1.8.7.3
Rhea expert-curated reactions1.8.7.3
UniProtKB/Swiss-Prot
Q8TLB0, HDRA1_METAC;  Q8TM02, HDRA2_METAC;  Q8Q0T0, HDRA_METMA;  
Q8TLB2, HDRB1_METAC;  Q8TIB8, HDRB2_METAC;  Q8PY83, HDRB_METMA;  
Q8TLB1, HDRC1_METAC;  Q8TIB9, HDRC2_METAC;  Q8PY84, HDRC_METMA;  

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