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ENZYME

ENZYME entry: EC 1.8.98.5

PURL: https://purl.expasy.org/enzyme/EC/1.8.98.5
Accepted Name
H2:CoB-CoM heterodisulfide,ferredoxin reductase
Reaction catalysed
coenzyme B + coenzyme M + 2 reduced [2Fe-2S]-[ferredoxin] + 2 H(+) = coenzyme M-coenzyme B heterodisulfide + 2 H2 + 2 oxidized [2Fe-2S]-[ferredoxin]
Comment(s)
  • This enzyme complex is found in H2-oxidizing CO2-reducing methanogenic archaea such as Methanothermobacter thermautotrophicus.
  • It consists of a cytoplasmic complex of HdrABC reductase and MvhAGD hydrogenase.
  • Electron pairs donated by the hydrogenase are transferred via its Delta subunit to the HdrA subunit of the reductase, where they are bifurcated, reducing both ferredoxin and CoB-CoM heterodisulfide.
  • The reductase can also form a similar complex with formate dehydrogenase, see EC 1.8.98.6, formate:CoB-CoM heterodisulfide,ferredoxin reductase. cf. EC 1.8.7.3, EC 1.8.98.4, and EC 1.8.98.1.
Cross-references
BRENDA1.8.98.5
EC2PDB1.8.98.5
ExplorEnz1.8.98.5
KEGG Ligand Database for Enzyme Nomenclature1.8.98.5
IUBMB Enzyme Nomenclature1.8.98.5
MEDLINEFind literature relating to 1.8.98.5
MetaCyc1.8.98.5
Rhea expert-curated reactions1.8.98.5
UniProtKB/Swiss-Prot
Q6LWL2, HDRA_METMPO27434, HDRA_METTHQ50756, HDRA_METTM
Q6LY38, HDRB1_METMPQ6LYD8, HDRB2_METMPO27907, HDRB_METTH
Q50755, HDRB_METTMQ6LY39, HDRC1_METMPQ6LYD7, HDRC2_METMP
O27906, HDRC_METTHQ50754, HDRC_METTM

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