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A new class EC 7, Translocases, has been added to the EC list. It will be part of ENZYME from release 2018_10. Read more about EC 7 here.

ENZYME entry: EC 1.8.98.5

Accepted Name
H(2):CoB-CoM heterodisulfide,ferredoxin reductase.
Reaction catalysed
2 reduced ferredoxin [iron-sulfur] cluster + CoB + CoM + 2 H(+) <=> 2 H(2) + 2 oxidized ferredoxin [iron-sulfur] cluster + CoM-S-S-CoB
Comment(s)
  • This enzyme complex is found in H(2)-oxidizing CO(2)-reducing methanogenic archaea such as Methanothermobacter thermautotrophicus.
  • It consists of a cytoplasmic complex of HdrABC reductase and MvhAGD hydrogenase.
  • Electron pairs donated by the hydrogenase are transfered via its Delta subunit to the HdrA subunit of the reductase, where they are bifurcated, reducing both ferredoxin and CoB-CoM heterodisulfide.
  • The reductase can also form a similar complex with formate dehydrogenase, see EC 1.8.98.6, formate:CoB-CoM heterodisulfide,ferredoxin reductase.
  • Cf. EC 1.8.7.3, EC 1.8.98.4, and EC 1.8.98.1.
Cross-references
BRENDA1.8.98.5
EC2PDB1.8.98.5
ExplorEnz1.8.98.5
PRIAM enzyme-specific profiles1.8.98.5
KEGG Ligand Database for Enzyme Nomenclature1.8.98.5
IUBMB Enzyme Nomenclature1.8.98.5
IntEnz1.8.98.5
MEDLINEFind literature relating to 1.8.98.5
MetaCyc1.8.98.5
UniProtKB/Swiss-Prot
Q6LWL2, HDRA_METMP;  O27434, HDRA_METTH;  Q50756, HDRA_METTM;  
Q6LY38, HDRB1_METMP;  Q6LYD8, HDRB2_METMP;  O27907, HDRB_METTH;  
Q50755, HDRB_METTM;  Q6LY39, HDRC1_METMP;  Q6LYD7, HDRC2_METMP;  
O27906, HDRC_METTH;  Q50754, HDRC_METTM;  

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