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ENZYME

ENZYME entry: EC 1.8.98.6

Accepted Name
formate:CoB-CoM heterodisulfide,ferredoxin reductase
Reaction catalysed
2 CO2 + coenzyme B + coenzyme M + 2 reduced [2Fe-2S]-[ferredoxin] = coenzyme M-coenzyme B heterodisulfide + 2 formate + 2 oxidized [2Fe-2S]-[ferredoxin]
Comment(s)
  • The enzyme is found in formate-oxidizing CO2-reducing methanogenic archaea such as Methanococcus maripaludis.
  • It consists of a cytoplasmic complex of HdrABC reductase and formate dehydrogenase.
  • Electron pairs donated by formate dehydrogenase are transferred to the HdrA subunit of the reductase, where they are bifurcated, reducing both ferredoxin and CoB-CoM heterodisulfide. cf. EC 1.8.7.3, EC 1.8.98.4, EC 1.8.98.5, and EC 1.8.98.1.
Cross-references
BRENDA1.8.98.6
EC2PDB1.8.98.6
ExplorEnz1.8.98.6
PRIAM enzyme-specific profiles1.8.98.6
KEGG Ligand Database for Enzyme Nomenclature1.8.98.6
IUBMB Enzyme Nomenclature1.8.98.6
IntEnz1.8.98.6
MEDLINEFind literature relating to 1.8.98.6
MetaCyc1.8.98.6
Rhea expert-curated reactions1.8.98.6
UniProtKB/Swiss-Prot
Q6LWL2, HDRA_METMPQ6LY38, HDRB1_METMPQ6LYD8, HDRB2_METMP
Q6LY39, HDRC1_METMPQ6LYD7, HDRC2_METMP

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