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ENZYME entry: EC

Accepted Name
coenzyme F420:CoB-CoM heterodisulfide,ferredoxin reductase
Reaction catalysed
coenzyme B + coenzyme M + 4 H(+) + 2 oxidized coenzyme F420-(gamma-L-Glu)(n) + 2 reduced [2Fe-2S]-[ferredoxin] = coenzyme M-coenzyme B heterodisulfide + 2 oxidized [2Fe-2S]-[ferredoxin] + 2 reduced coenzyme F420-(gamma-L-Glu)(n)
  • The enzyme, characterized from the archaeon Methanosarcina acetivorans, catalyzes the reduction of CoB-CoM heterodisulfide back to CoB and CoM.
  • The enzyme consists of three components, HdrA, HdrB and HdrC, all of which contain [4Fe-4S] clusters.
  • Electrons enter at HdrA, which also contains FAD, and are transferred via HdrC to the catalytic component, HdrB.
  • During methanogenesis from acetate the enzyme catalyzes the activity of EC
  • However, it can also use electron bifurcation to direct electron pairs from reduced coenzyme F420 toward the reduction of both ferredoxin and CoB-CoM heterodisulfide.
  • This activity is proposed to take place during Fe(III)-dependent anaerobic methane oxidation. cf. EC, EC, and EC
PRIAM enzyme-specific profiles1.8.98.4
KEGG Ligand Database for Enzyme Nomenclature1.8.98.4
IUBMB Enzyme Nomenclature1.8.98.4
MEDLINEFind literature relating to
Rhea expert-curated reactions1.8.98.4

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