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ENZYME entry: EC 1.8.98.4
| Accepted Name |
|---|
| Coenzyme F420:CoB-CoM heterodisulfide,ferredoxin reductase.
|
| Reaction catalysed |
|---|
| 2 oxidized coenzyme F420 + 2 reduced ferredoxin [iron-sulfur] cluster + CoB + CoM + 2 H(+) <=> 2 reduced coenzyme F420 + 2 oxidized ferredoxin [iron-sulfur] cluster + CoM-S-S-CoB |
| Comment(s) |
|---|
- The enzyme, characterized from the archaeon Methanosarcina
acetivorans, catalyzes the reduction of CoB-CoM heterodisulfide back
to CoB and CoM.
- The enzyme consists of three components, HdrA, HdrB and HdrC, all of
which contain [4Fe-4S] clusters.
- Electrons enter at HdrA, which also contains FAD, and are transferred
via HdrC to the catalytic component, HdrB.
- During methanogenesis from acetate the enzyme catalyzes the activity
of EC 1.8.7.3.
- However, it can also use electron bifurcation to direct electron
pairs from reduced coenzyme F420 toward the reduction of both
ferredoxin and CoB-CoM heterodisulfide.
- This activity is proposed to take place during Fe(III)-dependent
anaerobic methane oxidation.
- Cf. EC 1.8.98.5, EC 1.8.98.6, and EC 1.8.98.1.
|
| Cross-references |
|---|
| BRENDA | 1.8.98.4 |
| EC2PDB | 1.8.98.4 |
| ExplorEnz | 1.8.98.4 |
| PRIAM enzyme-specific profiles | 1.8.98.4 |
| KEGG Ligand Database for Enzyme Nomenclature | 1.8.98.4 |
| IUBMB Enzyme Nomenclature | 1.8.98.4 |
| IntEnz | 1.8.98.4 |
| MEDLINE | Find literature relating to 1.8.98.4 |
| MetaCyc | 1.8.98.4 |
| UniProtKB/Swiss-Prot |
|
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UniProtKB/Swiss-Prot entries corresponding to 1.8.98.-
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