ENZYME entry: EC 1.8.98.4
Accepted Name |
Coenzyme F420:CoB-CoM heterodisulfide,ferredoxin reductase.
|
Reaction catalysed |
2 oxidized coenzyme F420 + 2 reduced ferredoxin [iron-sulfur] cluster + CoB + CoM + 2 H(+) <=> 2 reduced coenzyme F420 + 2 oxidized ferredoxin [iron-sulfur] cluster + CoM-S-S-CoB |
Comment(s) |
- The enzyme, characterized from the archaeon Methanosarcina
acetivorans, catalyzes the reduction of CoB-CoM heterodisulfide back
to CoB and CoM.
- The enzyme consists of three components, HdrA, HdrB and HdrC, all of
which contain [4Fe-4S] clusters.
- Electrons enter at HdrA, which also contains FAD, and are transferred
via HdrC to the catalytic component, HdrB.
- During methanogenesis from acetate the enzyme catalyzes the activity
of EC 1.8.7.3.
- However, it can also use electron bifurcation to direct electron
pairs from reduced coenzyme F420 toward the reduction of both
ferredoxin and CoB-CoM heterodisulfide.
- This activity is proposed to take place during Fe(III)-dependent
anaerobic methane oxidation.
- Cf. EC 1.8.98.5, EC 1.8.98.6, and EC 1.8.98.1.
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Cross-references |
BRENDA | 1.8.98.4 |
EC2PDB | 1.8.98.4 |
ExplorEnz | 1.8.98.4 |
PRIAM enzyme-specific profiles | 1.8.98.4 |
KEGG Ligand Database for Enzyme Nomenclature | 1.8.98.4 |
IUBMB Enzyme Nomenclature | 1.8.98.4 |
IntEnz | 1.8.98.4 |
MEDLINE | Find literature relating to 1.8.98.4 |
MetaCyc | 1.8.98.4 |
Rhea expert-curated reactions | 1.8.98.4 |
UniProtKB/Swiss-Prot |
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