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ENZYME entry: EC 1.8.98.4
Accepted Name |
coenzyme F420:CoB-CoM heterodisulfide,ferredoxin reductase.
|
Reaction catalysed |
coenzyme B + coenzyme M + 4 H(+) + 2 oxidized coenzyme F420-(gamma-L-Glu)(n) + 2 reduced [2Fe-2S]-[ferredoxin] <=> coenzyme M-coenzyme B heterodisulfide + 2 oxidized [2Fe-2S]-[ferredoxin] + 2 reduced coenzyme F420-(gamma-L-Glu)(n) |
Comment(s) |
- The enzyme, characterized from the archaeon Methanosarcina
acetivorans, catalyzes the reduction of CoB-CoM heterodisulfide back
to CoB and CoM.
- The enzyme consists of three components, HdrA, HdrB and HdrC, all of
which contain [4Fe-4S] clusters.
- Electrons enter at HdrA, which also contains FAD, and are transferred
via HdrC to the catalytic component, HdrB.
- During methanogenesis from acetate the enzyme catalyzes the activity
of EC 1.8.7.3.
- However, it can also use electron bifurcation to direct electron
pairs from reduced coenzyme F420 toward the reduction of both
ferredoxin and CoB-CoM heterodisulfide.
- This activity is proposed to take place during Fe(III)-dependent
anaerobic methane oxidation. cf. EC 1.8.98.5, EC 1.8.98.6,
and EC 1.8.98.1.
|
Cross-references |
BRENDA | 1.8.98.4 |
EC2PDB | 1.8.98.4 |
ExplorEnz | 1.8.98.4 |
PRIAM enzyme-specific profiles | 1.8.98.4 |
KEGG Ligand Database for Enzyme Nomenclature | 1.8.98.4 |
IUBMB Enzyme Nomenclature | 1.8.98.4 |
IntEnz | 1.8.98.4 |
MEDLINE | Find literature relating to 1.8.98.4 |
MetaCyc | 1.8.98.4 |
Rhea expert-curated reactions | 1.8.98.4 |
UniProtKB/Swiss-Prot |
|
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ENZYME /
UniProtKB/Swiss-Prot entries corresponding to 1.8.98.-
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