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ENZYME entry: EC

Accepted Name
Coenzyme F420:CoB-CoM heterodisulfide,ferredoxin reductase.
Reaction catalysed
2 oxidized coenzyme F420 + 2 reduced ferredoxin [iron-sulfur] cluster + CoB + CoM + 2 H(+) <=> 2 reduced coenzyme F420 + 2 oxidized ferredoxin [iron-sulfur] cluster + CoM-S-S-CoB
  • The enzyme, characterized from the archaeon Methanosarcina acetivorans, catalyzes the reduction of CoB-CoM heterodisulfide back to CoB and CoM.
  • The enzyme consists of three components, HdrA, HdrB and HdrC, all of which contain [4Fe-4S] clusters.
  • Electrons enter at HdrA, which also contains FAD, and are transferred via HdrC to the catalytic component, HdrB.
  • During methanogenesis from acetate the enzyme catalyzes the activity of EC
  • However, it can also use electron bifurcation to direct electron pairs from reduced coenzyme F420 toward the reduction of both ferredoxin and CoB-CoM heterodisulfide.
  • This activity is proposed to take place during Fe(III)-dependent anaerobic methane oxidation.
  • Cf. EC, EC, and EC
PRIAM enzyme-specific profiles1.8.98.4
KEGG Ligand Database for Enzyme Nomenclature1.8.98.4
IUBMB Enzyme Nomenclature1.8.98.4
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