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A new class EC 7, Translocases, has been added to the EC list. It will be part of ENZYME from release 2018_10. Read more about EC 7 here.

ENZYME entry: EC 1.8.98.1

Accepted Name
Dihydromethanophenazine:CoB--CoM heterodisulfide reductase.
Alternative Name(s)
CoB--CoM heterodisulfide reductase.
Heterodisulfide reductase.
Reaction catalysed
CoB + CoM + methanophenazine <=> CoM-S-S-CoB + dihydromethanophenazine
Cofactor(s)
Heme; Iron-sulfur.
Comment(s)
  • This enzyme, found in methanogenic archaea that belong to the Methanosarcinales order, regenerates CoM and CoB after the action of EC 2.8.4.1.
  • It is a membrane-bound enzyme that contains (per heterodimeric unit) two distinct b-type hemes and two [4Fe-4S] clusters.
  • Cf. EC 1.8.7.3, EC 1.8.98.5, EC 1.8.98.6 and EC 1.8.98.4.
  • Formerly EC 1.12.99.2.
Cross-references
BRENDA1.8.98.1
EC2PDB1.8.98.1
ExplorEnz1.8.98.1
PRIAM enzyme-specific profiles1.8.98.1
KEGG Ligand Database for Enzyme Nomenclature1.8.98.1
IUBMB Enzyme Nomenclature1.8.98.1
IntEnz1.8.98.1
MEDLINEFind literature relating to 1.8.98.1
MetaCyc1.8.98.1
UniProtKB/Swiss-Prot
Q8TSV7, HDRD_METAC;  P96797, HDRD_METBF;  Q8PVW3, HDRD_METMA;  
A0A0E3NEE1, HDRD_METTT;  Q8TSV8, HDRE_METAC;  P96796, HDRE_METBF;  
Q8PVW4, HDRE_METMA;  A0A0E3NFS5, HDRE_METTT;  

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