Expasy logo

ENZYME

ENZYME entry: EC 2.1.1.370

PURL: https://purl.expasy.org/enzyme/EC/2.1.1.370
Accepted Name
[histone H3]-lysine(4) N-dimethyltransferase
Reaction catalysed
L-lysyl(4)-[histone H3] + 2 S-adenosyl-L-methionine = N(6),N(6)-dimethyl-L-lysyl(4)-[histone H3] + 2 S-adenosyl-L-homocysteine + 2 H(+)
Comment(s)
  • This entry describes enzymes that successively methylate the L-lysine(4) residue of histone H3 (H3K4) twice, ultimately generating a dimethylated form.
  • These modifications influence the binding of chromatin-associated proteins.The human NSD3 protein also catalyzes the activity of EC 2.1.1.371. cf. EC 2.1.1.354 and EC 2.1.1.364.
Cross-references
BRENDA2.1.1.370
EC2PDB2.1.1.370
ExplorEnz2.1.1.370
KEGG Ligand Database for Enzyme Nomenclature2.1.1.370
IUBMB Enzyme Nomenclature2.1.1.370
MEDLINEFind literature relating to 2.1.1.370
MetaCyc2.1.1.370
Rhea expert-curated reactions2.1.1.370
UniProtKB/Swiss-Prot
Q9BZ95, NSD3_HUMANQ6P2L6, NSD3_MOUSE

View entry in original ENZYME format
View entry in raw text format (no links)
All UniProtKB/Swiss-Prot entries referenced in this entry, with possibility to download in different formats, align etc.
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 2.1.1.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 2.1.-.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 2.-.-.-