ENZYME entry: EC 2.1.1.370
Accepted Name |
[histone H3]-lysine(4) N-dimethyltransferase.
|
Reaction catalysed |
L-lysyl(4)-[histone H3] + 2 S-adenosyl-L-methionine <=> 2 H(+) + N(6),N(6)-dimethyl-L-lysyl(4)-[histone H3] + 2 S-adenosyl-L-homocysteine |
Comment(s) |
- This entry describes enzymes that successively methylate the
L-lysine(4) residue of histone H3 (H3K4) twice, ultimately generating
a dimethylated form.
- These modifications influence the binding of chromatin-associated
proteins.The human NSD3 protein also catalyzes the activity of
EC 2.1.1.371. cf. EC 2.1.1.354 and EC 2.1.1.364.
|
Cross-references |
BRENDA | 2.1.1.370 |
EC2PDB | 2.1.1.370 |
ExplorEnz | 2.1.1.370 |
PRIAM enzyme-specific profiles | 2.1.1.370 |
KEGG Ligand Database for Enzyme Nomenclature | 2.1.1.370 |
IUBMB Enzyme Nomenclature | 2.1.1.370 |
IntEnz | 2.1.1.370 |
MEDLINE | Find literature relating to 2.1.1.370 |
MetaCyc | 2.1.1.370 |
Rhea expert-curated reactions | 2.1.1.370 |
UniProtKB/Swiss-Prot |
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