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ENZYME entry: EC 2.1.1.370

Accepted Name
[histone H3]-lysine(4) N-dimethyltransferase.
Reaction catalysed
L-lysyl(4)-[histone H3] + 2 S-adenosyl-L-methionine <=> 2 H(+) + N(6),N(6)-dimethyl-L-lysyl(4)-[histone H3] + 2 S-adenosyl-L-homocysteine
Comment(s)
  • This entry describes enzymes that successively methylate the L-lysine(4) residue of histone H3 (H3K4) twice, ultimately generating a dimethylated form.
  • These modifications influence the binding of chromatin-associated proteins.The human NSD3 protein also catalyzes the activity of EC 2.1.1.371.
  • Cf. EC 2.1.1.364 and EC 2.1.1.354.
Cross-references
BRENDA2.1.1.370
EC2PDB2.1.1.370
ExplorEnz2.1.1.370
PRIAM enzyme-specific profiles2.1.1.370
KEGG Ligand Database for Enzyme Nomenclature2.1.1.370
IUBMB Enzyme Nomenclature2.1.1.370
IntEnz2.1.1.370
MEDLINEFind literature relating to 2.1.1.370
MetaCyc2.1.1.370
Rhea expert-curated reactions2.1.1.370
UniProtKB/Swiss-Prot
Q9BZ95, NSD3_HUMAN;  Q6P2L6, NSD3_MOUSE;  

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