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ENZYME entry: EC 2.3.1.282

Accepted Name
Phenolphthiocerol/phthiocerol/phthiodiolone dimycocerosyl transferase.
Reaction catalysed
  • 2 a mycocerosyl-[mycocerosic acid synthase] + a phthiocerol <=> a dimycocerosyl phthiocerol + 2 holo-[mycocerosic acid synthase]
  • 2 a mycocerosyl-[mycocerosic acid synthase] + a phthiodiolone <=> a dimycocerosyl phthiodiolone + 2 holo-[mycocerosic acid synthase]
  • 2 a mycocerosyl-[mycocerosic acid synthase] + a phenolphthiocerol <=> a dimycocerosyl phenolphthiocerol + 2 holo-[mycocerosic acid synthase]
Comment(s)
  • The enzyme, present in certain pathogenic species of mycobacteria, catalyzes the transfer of mycocerosic acids to the two hydroxyl groups at the common lipid core of phthiocerol, phthiodiolone, and phenolphthiocerol, forming dimycocerosate esters.
  • The fatty acid precursors of mycocerosic acids are activated by EC 6.2.1.49, which loads them onto EC 2.3.1.111.
  • That enzyme extends the precursors to form mycocerosic acids that remain attached until transferred by EC 2.3.1.282.
Cross-references
BRENDA2.3.1.282
EC2PDB2.3.1.282
ExplorEnz2.3.1.282
PRIAM enzyme-specific profiles2.3.1.282
KEGG Ligand Database for Enzyme Nomenclature2.3.1.282
IUBMB Enzyme Nomenclature2.3.1.282
IntEnz2.3.1.282
MEDLINEFind literature relating to 2.3.1.282
MetaCyc2.3.1.282
UniProtKB/Swiss-Prot
Q02279, PAPA5_MYCBO;  A1KMT4, PAPA5_MYCBP;  Q49939, PAPA5_MYCLE;  
A3Q0G0, PAPA5_MYCSJ;  A1UGV8, PAPA5_MYCSK;  Q1B849, PAPA5_MYCSS;  
A5U6U6, PAPA5_MYCTA;  P9WIN4, PAPA5_MYCTO;  P9WIN5, PAPA5_MYCTU;  
A0PQ31, PAPA5_MYCUA;  A1T9S1, PAPA5_MYCVP;  

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