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ENZYME

ENZYME entry: EC 2.7.8.26

Accepted Name
adenosylcobinamide-GDP ribazoletransferase
Alternative Name(s)
cobalamin (5'-phosphate) synthase
cobalamin-5'-phosphate synthase
cobalamin synthase
Reaction catalysed
  • adenosylcob(III)inamide-GDP + alpha-ribazole <=> adenosylcob(III)alamin + GMP + H(+)
  • adenosylcob(III)inamide-GDP + alpha-ribazole 5'-phosphate <=> adenosylcob(III)alamin 5'-phosphate + GMP + H(+)
Comment(s)
  • In Salmonella typhimurium LT2, under anaerobic conditions, CobU (EC 2.7.7.62 and EC 2.7.1.156), CobT (EC 2.4.2.21), CobC (EC 3.1.3.73) and CobS (EC 2.7.8.26) catalyze reactions in the nucleotide loop assembly pathway, which convert adenosylcobinamide (AdoCbi) into adenosylcobalamin (AdoCbl).
  • CobT and CobC are involved in 5,6-dimethylbenzimidazole activation whereby 5,6-dimethylbenzimidazole is converted to its riboside, alpha-ribazole.
  • The second branch of the nucleotide loop assembly pathway is the cobinamide (Cbi) activation branch where AdoCbi or adenosylcobinamide-phosphate is converted to the activated intermediate AdoCbi-GDP by the bifunctional enzyme CobU.
  • CobS catalyzes the final step in adenosylcobalamin biosynthesis, which is the condensation of AdoCbi-GDP with alpha-ribazole to yield adenosylcobalamin.
Cross-references
BRENDA2.7.8.26
EC2PDB2.7.8.26
ExplorEnz2.7.8.26
PRIAM enzyme-specific profiles2.7.8.26
KEGG Ligand Database for Enzyme Nomenclature2.7.8.26
IUBMB Enzyme Nomenclature2.7.8.26
IntEnz2.7.8.26
MEDLINEFind literature relating to 2.7.8.26
MetaCyc2.7.8.26
Rhea expert-curated reactions2.7.8.26
UniProtKB/Swiss-Prot
O30198, COBS1_ARCFUO27961, COBS2_ARCFUA3DK68, COBS_ACET2
B2HZL6, COBS_ACIBCA3M596, COBS_ACIBTB9JG16, COBS_AGRRK
B9JW08, COBS_AGRVSQ21V77, COBS_ALBFTQ0A4T1, COBS_ALKEH
A6TU75, COBS_ALKMQA8MIW2, COBS_ALKOOQ5P2R7, COBS_AROAE
A8ID91, COBS_AZOC5Q89Q75, COBS_BRADUC0Z7H6, COBS_BREBN
B2S5A0, COBS_BRUA1Q2YNK8, COBS_BRUA2A6X1H1, COBS_BRUA4
Q57DP0, COBS_BRUABA9MAN9, COBS_BRUC2C0RIJ9, COBS_BRUMB
Q8YGQ8, COBS_BRUMEA5VQ44, COBS_BRUO2B0CLJ1, COBS_BRUSI
Q8G156, COBS_BRUSUQ8RCN8, COBS_CALS4Q3AE01, COBS_CARHZ
Q3ARQ6, COBS_CHLCHB3QNS4, COBS_CHLP8B3EJP7, COBS_CHLPB
A4SEC9, COBS_CHLPMQ8KDU6, COBS_CHLTEA8AER0, COBS_CITK8
Q97JA2, COBS_CLOABA7FS72, COBS_CLOB1C3L2A5, COBS_CLOB6
A6LSW5, COBS_CLOB8B2UXE0, COBS_CLOBAB2TPF2, COBS_CLOBB
A5I013, COBS_CLOBHC1FUP2, COBS_CLOBJB1IGK6, COBS_CLOBK
A7GBL1, COBS_CLOBLB1KX15, COBS_CLOBMQ180T5, COBS_CLOD6
B9E675, COBS_CLOK1A5N2J8, COBS_CLOK5A0Q0K0, COBS_CLONN
Q0TRK3, COBS_CLOP1Q8XLK5, COBS_CLOPEQ0STX5, COBS_CLOPS
Q897L5, COBS_CLOTEQ6NG92, COBS_CORDIQ8FNQ1, COBS_COREF
A4QFR6, COBS_CORGBQ8NNJ7, COBS_CORGLQ9RYR9, COBS_DEIRA
Q24VN7, COBS_DESHYA4J804, COBS_DESRMQ72DL5, COBS_DESVH
B8DRQ3, COBS_DESVMA1VF70, COBS_DESVVA7ZNF6, COBS_ECO24
B7UT21, COBS_ECO27B7MDB8, COBS_ECO45B7L917, COBS_ECO55
Q8X8U9, COBS_ECO57B5YSS1, COBS_ECO5EB7NR82, COBS_ECO7I
B7MWP9, COBS_ECO81B7M3C8, COBS_ECO8AC4ZQQ5, COBS_ECOBW
B1X6T0, COBS_ECODHA8A1K6, COBS_ECOHSQ0TGE0, COBS_ECOL5
Q8FGA4, COBS_ECOL6B1IZQ8, COBS_ECOLCP36561, COBS_ECOLI
B7NC26, COBS_ECOLUB6I829, COBS_ECOSEB1LPV6, COBS_ECOSM
A7HMT2, COBS_FERNBQ2J8A4, COBS_FRACCQ8R666, COBS_FUSNN
B9LZU3, COBS_GEODFQ5KXP1, COBS_GEOKAC5D3K0, COBS_GEOSW
A4IQD8, COBS_GEOTNQ9KCH9, COBS_HALH5B9LRL5, COBS_HALLT
Q9HPL2, COBS_HALSAQ18KB3, COBS_HALWDA9AYY2, COBS_HERA2
B5XPI1, COBS_KLEP3A6TBB1, COBS_KLEP7C5CE71, COBS_KOSOT
A9KMP0, COBS_LACP7C1D6F9, COBS_LARHHB0SFE6, COBS_LEPBA
B0SNZ5, COBS_LEPBPB1Y854, COBS_LEPCPQ72M34, COBS_LEPIC
Q8EYK8, COBS_LEPINQ92CQ9, COBS_LISINC1L254, COBS_LISMC
Q720T3, COBS_LISMFB8DC84, COBS_LISMHQ8Y7X1, COBS_LISMO
A0AHP2, COBS_LISW6Q8TS66, COBS_METACQ0W1P5, COBS_METAR
Q465W3, COBS_METBFQ12UB0, COBS_METBUQ58833, COBS_METJA
Q8TUT2, COBS_METKAQ8PVB4, COBS_METMAO27184, COBS_METTH
A0QEZ8, COBS_MYCA1Q7VEN6, COBS_MYCBOA1KKQ0, COBS_MYCBP
C1AQC3, COBS_MYCBTA4TBJ8, COBS_MYCGIB2HGX7, COBS_MYCMM
Q73YK6, COBS_MYCPAA0R065, COBS_MYCS2A3Q1R8, COBS_MYCSJ
A1UIA4, COBS_MYCSKQ1B6S1, COBS_MYCSSA5U4N6, COBS_MYCTA
P9WP90, COBS_MYCTOP9WP91, COBS_MYCTUA0PTP3, COBS_MYCUA
A1TB16, COBS_MYCVPA1SJN0, COBS_NOCSJQ8YZS8, COBS_NOSS1
Q2GBJ9, COBS_NOVADB4SH93, COBS_PELPBQ6L174, COBS_PICTO
A1VJY2, COBS_POLNAQ12FJ6, COBS_POLSJB4S891, COBS_PROA2
A2CCL0, COBS_PROM3Q7VDR6, COBS_PROMAQ7V4T2, COBS_PROMM
Q48FK1, COBS_PSE14Q15WS4, COBS_PSEA6A6V8S8, COBS_PSEA7
Q02JC2, COBS_PSEABQ9I463, COBS_PSEAEQ1IDJ5, COBS_PSEE4
Q4K8C3, COBS_PSEF5C3K0Y6, COBS_PSEFSA4XT57, COBS_PSEMY
A5W7Q2, COBS_PSEP1Q3KFR3, COBS_PSEPFB0KT69, COBS_PSEPG
Q88M93, COBS_PSEPKB1J1P0, COBS_PSEPWQ885W4, COBS_PSESM
Q4ZQ68, COBS_PSEU2Q9V2N1, COBS_PYRABQ8ZZ89, COBS_PYRAE
A3MWD7, COBS_PYRCJQ8U400, COBS_PYRFUO58111, COBS_PYRHO
A1RUA0, COBS_PYRILB2UAJ1, COBS_RALPJQ8XWS4, COBS_RALSO
B3PQS4, COBS_RHIE6Q2K7G5, COBS_RHIECQ1MFK3, COBS_RHIL3
Q98KP0, COBS_RHILOB5ZSC5, COBS_RHILWQ92P97, COBS_RHIME
A5V212, COBS_ROSS1Q97TZ6, COBS_SACS2A9MLS7, COBS_SALAR
Q57MY0, COBS_SALCHB5FLY5, COBS_SALDCB5QYX4, COBS_SALEP
B5RBK7, COBS_SALG2B4T8W9, COBS_SALHSB4SWC6, COBS_SALNS
Q5PDU1, COBS_SALPAC0Q1Q9, COBS_SALPCB5BG59, COBS_SALPK
B4TZP6, COBS_SALSVQ8Z5N8, COBS_SALTIQ05602, COBS_SALTY
A1S3L4, COBS_SHEAMA3D7X7, COBS_SHEB5A6WJZ2, COBS_SHEB8
A9L3D9, COBS_SHEB9Q12Q70, COBS_SHEDOQ086T5, COBS_SHEFN
B0TSP8, COBS_SHEHHQ8EI17, COBS_SHEONA8H806, COBS_SHEPA
A4Y9P2, COBS_SHEPCB8CJ38, COBS_SHEPWA0L0D2, COBS_SHESA
Q0HLZ4, COBS_SHESMQ0HRU2, COBS_SHESRA1RGP2, COBS_SHESW
B1KH27, COBS_SHEWMB2TWQ9, COBS_SHIB3Q322B3, COBS_SHIBS
Q32ED1, COBS_SHIDSQ0T3C3, COBS_SHIF8Q83R13, COBS_SHIFL
Q3Z0K3, COBS_SHISSA6U9W5, COBS_SINMWA4VJ44, COBS_STUS1
Q4JBK2, COBS_SULACC3N0R7, COBS_SULIAC4KJU4, COBS_SULIK
C3MJX7, COBS_SULILC3MRS8, COBS_SULIMC3NMG6, COBS_SULIN
C3N903, COBS_SULIYQ96Y25, COBS_SULTOQ8GMS2, COBS_SYNE7
A0LLI5, COBS_SYNFMQ5N366, COBS_SYNP6Q55714, COBS_SYNY3
B7IHD7, COBS_THEABQ9HJ91, COBS_THEACC5A478, COBS_THEGJ
Q52454, COBS_THEKOA6LLB7, COBS_THEM4B6YV94, COBS_THEON
B0KCS0, COBS_THEP3B0K2K2, COBS_THEPXQ8DJ91, COBS_THEVB
Q97BG1, COBS_THEVOB5YL84, COBS_THEYDQ3SFE7, COBS_THIDA
Q73K39, COBS_TREDEQ3M999, COBS_TRIV2A5F1U5, COBS_VIBC3
Q9KSL8, COBS_VIBCHC3LLT4, COBS_VIBCMQ87Q45, COBS_VIBPA
Q8D922, COBS_VIBVUQ7MLF2, COBS_VIBVYA7IB66, COBS_XANP2
P29936, COBV_SINSX

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All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 2.7.8.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 2.7.-.-
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