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ENZYME

ENZYME entry: EC 2.7.8.26

Accepted Name
adenosylcobinamide-GDP ribazoletransferase
Alternative Name(s)
cobalamin (5'-phosphate) synthase
cobalamin-5'-phosphate synthase
cobalamin synthase
Reaction catalysed
  • adenosylcob(III)inamide-GDP + alpha-ribazole <=> adenosylcob(III)alamin + GMP + H(+)
  • adenosylcob(III)inamide-GDP + alpha-ribazole 5'-phosphate <=> adenosylcob(III)alamin 5'-phosphate + GMP + H(+)
Comment(s)
  • In Salmonella typhimurium LT2, under anaerobic conditions, CobU (EC 2.7.7.62 and EC 2.7.1.156), CobT (EC 2.4.2.21), CobC (EC 3.1.3.73) and CobS (EC 2.7.8.26) catalyze reactions in the nucleotide loop assembly pathway, which convert adenosylcobinamide (AdoCbi) into adenosylcobalamin (AdoCbl).
  • CobT and CobC are involved in 5,6-dimethylbenzimidazole activation whereby 5,6-dimethylbenzimidazole is converted to its riboside, alpha-ribazole.
  • The second branch of the nucleotide loop assembly pathway is the cobinamide (Cbi) activation branch where AdoCbi or adenosylcobinamide-phosphate is converted to the activated intermediate AdoCbi-GDP by the bifunctional enzyme CobU.
  • CobS catalyzes the final step in adenosylcobalamin biosynthesis, which is the condensation of AdoCbi-GDP with alpha-ribazole to yield adenosylcobalamin.
Cross-references
BRENDA2.7.8.26
EC2PDB2.7.8.26
ExplorEnz2.7.8.26
PRIAM enzyme-specific profiles2.7.8.26
KEGG Ligand Database for Enzyme Nomenclature2.7.8.26
IUBMB Enzyme Nomenclature2.7.8.26
IntEnz2.7.8.26
MEDLINEFind literature relating to 2.7.8.26
MetaCyc2.7.8.26
Rhea expert-curated reactions2.7.8.26
UniProtKB/Swiss-Prot
O30198, COBS1_ARCFUO27961, COBS2_ARCFUA3DK68, COBS_ACET2
B2HZL6, COBS_ACIBCA3M596, COBS_ACIBTQ21V77, COBS_ALBFT
Q0A4T1, COBS_ALKEHA6TU75, COBS_ALKMQA8MIW2, COBS_ALKOO
B9JW08, COBS_ALLAMQ5P2R7, COBS_AROAEA8ID91, COBS_AZOC5
Q89Q75, COBS_BRADUC0Z7H6, COBS_BREBNB2S5A0, COBS_BRUA1
Q2YNK8, COBS_BRUA2A6X1H1, COBS_BRUA4Q57DP0, COBS_BRUAB
A9MAN9, COBS_BRUC2C0RIJ9, COBS_BRUMBQ8YGQ8, COBS_BRUME
A5VQ44, COBS_BRUO2B0CLJ1, COBS_BRUSIQ8G156, COBS_BRUSU
Q8RCN8, COBS_CALS4Q3AE01, COBS_CARHZQ3ARQ6, COBS_CHLCH
B3QNS4, COBS_CHLP8B3EJP7, COBS_CHLPBA4SEC9, COBS_CHLPM
Q8KDU6, COBS_CHLTEA8AER0, COBS_CITK8Q97JA2, COBS_CLOAB
A7FS72, COBS_CLOB1C3L2A5, COBS_CLOB6A6LSW5, COBS_CLOB8
B2UXE0, COBS_CLOBAB2TPF2, COBS_CLOBBA5I013, COBS_CLOBH
C1FUP2, COBS_CLOBJB1IGK6, COBS_CLOBKA7GBL1, COBS_CLOBL
B1KX15, COBS_CLOBMQ180T5, COBS_CLOD6B9E675, COBS_CLOK1
A5N2J8, COBS_CLOK5A0Q0K0, COBS_CLONNQ0TRK3, COBS_CLOP1
Q8XLK5, COBS_CLOPEQ0STX5, COBS_CLOPSQ897L5, COBS_CLOTE
Q6NG92, COBS_CORDIQ8FNQ1, COBS_COREFA4QFR6, COBS_CORGB
Q8NNJ7, COBS_CORGLQ9RYR9, COBS_DEIRAQ24VN7, COBS_DESHY
A4J804, COBS_DESRMA7ZNF6, COBS_ECO24B7UT21, COBS_ECO27
B7MDB8, COBS_ECO45B7L917, COBS_ECO55Q8X8U9, COBS_ECO57
B5YSS1, COBS_ECO5EB7NR82, COBS_ECO7IB7MWP9, COBS_ECO81
B7M3C8, COBS_ECO8AC4ZQQ5, COBS_ECOBWB1X6T0, COBS_ECODH
A8A1K6, COBS_ECOHSQ0TGE0, COBS_ECOL5Q8FGA4, COBS_ECOL6
B1IZQ8, COBS_ECOLCP36561, COBS_ECOLIB7NC26, COBS_ECOLU
B6I829, COBS_ECOSEB1LPV6, COBS_ECOSMA7HMT2, COBS_FERNB
Q2J8A4, COBS_FRACCQ8R666, COBS_FUSNNB9LZU3, COBS_GEODF
Q5KXP1, COBS_GEOKAC5D3K0, COBS_GEOSWA4IQD8, COBS_GEOTN
Q9KCH9, COBS_HALH5B9LRL5, COBS_HALLTQ9HPL2, COBS_HALSA
Q18KB3, COBS_HALWDA9AYY2, COBS_HERA2B5XPI1, COBS_KLEP3
A6TBB1, COBS_KLEP7C5CE71, COBS_KOSOTA9KMP0, COBS_LACP7
C1D6F9, COBS_LARHHB0SFE6, COBS_LEPBAB0SNZ5, COBS_LEPBP
B1Y854, COBS_LEPCPQ72M34, COBS_LEPICQ8EYK8, COBS_LEPIN
Q92CQ9, COBS_LISINC1L254, COBS_LISMCQ720T3, COBS_LISMF
B8DC84, COBS_LISMHQ8Y7X1, COBS_LISMOA0AHP2, COBS_LISW6
Q8TS66, COBS_METACQ0W1P5, COBS_METARQ465W3, COBS_METBF
Q12UB0, COBS_METBUQ58833, COBS_METJAQ8TUT2, COBS_METKA
Q8PVB4, COBS_METMAO27184, COBS_METTHA0QEZ8, COBS_MYCA1
Q7VEN6, COBS_MYCBOA1KKQ0, COBS_MYCBPC1AQC3, COBS_MYCBT
A4TBJ8, COBS_MYCGIB2HGX7, COBS_MYCMMQ73YK6, COBS_MYCPA
A0R065, COBS_MYCS2A3Q1R8, COBS_MYCSJA1UIA4, COBS_MYCSK
Q1B6S1, COBS_MYCSSA5U4N6, COBS_MYCTAP9WP90, COBS_MYCTO
P9WP91, COBS_MYCTUA0PTP3, COBS_MYCUAA1TB16, COBS_MYCVP
Q72DL5, COBS_NITV2A1VF70, COBS_NITV4B8DRQ3, COBS_NITV9
A1SJN0, COBS_NOCSJQ8YZS8, COBS_NOSS1Q2GBJ9, COBS_NOVAD
B4SH93, COBS_PELPBQ6L174, COBS_PICTOA1VJY2, COBS_POLNA
Q12FJ6, COBS_POLSJB4S891, COBS_PROA2A2CCL0, COBS_PROM3
Q7VDR6, COBS_PROMAQ7V4T2, COBS_PROMMQ48FK1, COBS_PSE14
Q15WS4, COBS_PSEA6A6V8S8, COBS_PSEA7Q02JC2, COBS_PSEAB
Q9I463, COBS_PSEAEQ1IDJ5, COBS_PSEE4Q4K8C3, COBS_PSEF5
C3K0Y6, COBS_PSEFSA4XT57, COBS_PSEMYA5W7Q2, COBS_PSEP1
Q3KFR3, COBS_PSEPFB0KT69, COBS_PSEPGQ88M93, COBS_PSEPK
B1J1P0, COBS_PSEPWQ885W4, COBS_PSESMQ4ZQ68, COBS_PSEU2
Q9V2N1, COBS_PYRABQ8ZZ89, COBS_PYRAEA3MWD7, COBS_PYRCJ
Q8U400, COBS_PYRFUO58111, COBS_PYRHOA1RUA0, COBS_PYRIL
Q8XWS4, COBS_RALN1B2UAJ1, COBS_RALPJB3PQS4, COBS_RHIE6
Q2K7G5, COBS_RHIECQ1MFK3, COBS_RHIJ3Q98KP0, COBS_RHILO
B5ZSC5, COBS_RHILWQ92P97, COBS_RHIMEB9JG16, COBS_RHIR8
A5V212, COBS_ROSS1Q97TZ6, COBS_SACS2A9MLS7, COBS_SALAR
Q57MY0, COBS_SALCHB5FLY5, COBS_SALDCB5QYX4, COBS_SALEP
B5RBK7, COBS_SALG2B4T8W9, COBS_SALHSB4SWC6, COBS_SALNS
Q5PDU1, COBS_SALPAC0Q1Q9, COBS_SALPCB5BG59, COBS_SALPK
B4TZP6, COBS_SALSVQ8Z5N8, COBS_SALTIQ05602, COBS_SALTY
A1S3L4, COBS_SHEAMA3D7X7, COBS_SHEB5A6WJZ2, COBS_SHEB8
A9L3D9, COBS_SHEB9Q12Q70, COBS_SHEDOQ086T5, COBS_SHEFN
B0TSP8, COBS_SHEHHQ8EI17, COBS_SHEONA8H806, COBS_SHEPA
A4Y9P2, COBS_SHEPCB8CJ38, COBS_SHEPWA0L0D2, COBS_SHESA
Q0HLZ4, COBS_SHESMQ0HRU2, COBS_SHESRA1RGP2, COBS_SHESW
B1KH27, COBS_SHEWMB2TWQ9, COBS_SHIB3Q322B3, COBS_SHIBS
Q32ED1, COBS_SHIDSQ0T3C3, COBS_SHIF8Q83R13, COBS_SHIFL
Q3Z0K3, COBS_SHISSA6U9W5, COBS_SINMWA4VJ44, COBS_STUS1
Q4JBK2, COBS_SULACC3N0R7, COBS_SULIAC4KJU4, COBS_SULIK
C3MJX7, COBS_SULILC3MRS8, COBS_SULIMC3NMG6, COBS_SULIN
C3N903, COBS_SULIYQ96Y25, COBS_SULTOQ8GMS2, COBS_SYNE7
A0LLI5, COBS_SYNFMQ5N366, COBS_SYNP6Q55714, COBS_SYNY3
B7IHD7, COBS_THEABQ9HJ91, COBS_THEACC5A478, COBS_THEGJ
Q52454, COBS_THEKOA6LLB7, COBS_THEM4B6YV94, COBS_THEON
B0KCS0, COBS_THEP3B0K2K2, COBS_THEPXQ8DJ91, COBS_THEVB
Q97BG1, COBS_THEVOB5YL84, COBS_THEYDQ3SFE7, COBS_THIDA
Q73K39, COBS_TREDEQ3M999, COBS_TRIV2A5F1U5, COBS_VIBC3
Q9KSL8, COBS_VIBCHC3LLT4, COBS_VIBCMQ87Q45, COBS_VIBPA
Q8D922, COBS_VIBVUQ7MLF2, COBS_VIBVYA7IB66, COBS_XANP2
P29936, COBV_SINSX

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All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 2.7.8.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 2.7.-.-
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