- Catalyzes the hydrolysis of trans-substituted epoxides, such as
trans-stilbene oxide, as well as various aliphatic epoxides derived
from fatty-acid metabolism.
- It is involved in the metabolism of arachidonic epoxides
(epoxyeicosatrienoic acids; EETs) and linoleic acid epoxides.
- The enzyme from mammals is a bifunctional enzyme: the C-terminal
domain exhibits epoxide-hydrolase activity and the N-terminal domain
has the activity of EC 3.1.3.76.
- Like EC 3.3.2.9, it is probable that the reaction involves the
formation of an hydroxyalkyl-enzyme intermediate.
- The enzyme can also use leukotriene A(4), the substrate of
EC 3.3.2.6, but it forms 5,6-dihydroxy-7,9,11,14-eicosatetraenoic
acid rather than leukotriene B(4) as the product.
- Formerly EC 3.3.2.3, EC 4.2.1.63 and EC 4.2.1.64.
|
| UniProtKB/Swiss-Prot |
| G5EBI4, CEEH1_CAEEL; | G5EDL5, CEEH2_CAEEL; | I6YGS0, EPHA_MYCTU; |
| P95276, EPHB_MYCTO; | I6YC03, EPHB_MYCTU; | O33283, EPHG_MYCTU; |
| Q9H6B9, EPHX3_HUMAN; | Q3V1F8, EPHX3_MOUSE; | Q0IIS3, EPHX3_XENTR; |
| P80048, HYEP_PSEU1; | Q06816, HYEP_STIAD; | O52866, HYES_CORS2; |
| P34913, HYES_HUMAN; | P34914, HYES_MOUSE; | Q6Q2C2, HYES_PIG; |
| P80299, HYES_RAT; | A5DME6, LKA41_PICGU; | A3LRX6, LKA41_PICST; |
| A5DGF3, LKA42_PICGU; | A3LQI7, LKA42_PICST; | A6RCT2, LKHA4_AJECN; |
| Q9FY49, LKHA4_ARATH; | Q75B10, LKHA4_ASHGO; | A1CSI2, LKHA4_ASPCL; |
| Q4X265, LKHA4_ASPFU; | A2QKF8, LKHA4_ASPNC; | Q2TZ99, LKHA4_ASPOR; |
| Q0CFY9, LKHA4_ASPTN; | Q59NB8, LKHA4_CANAL; | Q6FTM0, LKHA4_CANGA; |
| Q2GY21, LKHA4_CHAGB; | Q1DVD1, LKHA4_COCIM; | Q6BW21, LKHA4_DEBHA; |
| P52922, LKHA4_DICDI; | Q5B0W8, LKHA4_EMENI; | Q6CLD3, LKHA4_KLULA; |
| A5DSS4, LKHA4_LODEL; | A4QUC1, LKHA4_MAGO7; | A1DG68, LKHA4_NEOFI; |
| Q7S785, LKHA4_NEUCR; | Q84TA3, LKHA4_ORYSJ; | Q0U653, LKHA4_PHANO; |
| O94544, LKHA4_SCHPO; | A7EJL9, LKHA4_SCLS1; | A7THG7, LKHA4_VANPO; |
| Q6C3E5, LKHA4_YARLI; | A6ZS33, LKHA4_YEAS7; | Q10740, LKHA4_YEAST; |
|