A new class EC 7, Translocases, has been added to the EC list. It will be part of ENZYME from release 2018_09. Read more about EC 7 here.

ENZYME entry: EC 3.3.2.10

Accepted Name
Soluble epoxide hydrolase.
Alternative Name(s)
Arene-oxide hydratase.
Aryl epoxide hydrase.
Cytosolic epoxide hydrolase.
Epoxide hydrase.
Epoxide hydratase.
Trans-stilbene oxide hydrolase.
Reaction catalysed
An epoxide + H(2)O <=> a glycol
Comment(s)
  • Catalyzes the hydrolysis of trans-substituted epoxides, such as trans-stilbene oxide, as well as various aliphatic epoxides derived from fatty-acid metabolism.
  • It is involved in the metabolism of arachidonic epoxides (epoxyeicosatrienoic acids; EETs) and linoleic acid epoxides.
  • The enzyme from mammals is a bifunctional enzyme: the C-terminal domain exhibits epoxide-hydrolase activity and the N-terminal domain has the activity of EC 3.1.3.76.
  • Like EC 3.3.2.9, it is probable that the reaction involves the formation of an hydroxyalkyl-enzyme intermediate.
  • The enzyme can also use leukotriene A(4), the substrate of EC 3.3.2.6, but it forms 5,6-dihydroxy-7,9,11,14-eicosatetraenoic acid rather than leukotriene B(4) as the product.
  • Formerly EC 3.3.2.3, EC 4.2.1.63 and EC 4.2.1.64.
Cross-references
BRENDA3.3.2.10
EC2PDB3.3.2.10
ExplorEnz3.3.2.10
PRIAM enzyme-specific profiles3.3.2.10
KEGG Ligand Database for Enzyme Nomenclature3.3.2.10
IUBMB Enzyme Nomenclature3.3.2.10
IntEnz3.3.2.10
MEDLINEFind literature relating to 3.3.2.10
MetaCyc3.3.2.10
UniProtKB/Swiss-Prot
G5EBI4, CEEH1_CAEEL;  G5EDL5, CEEH2_CAEEL;  I6YGS0, EPHA_MYCTU;  
P95276, EPHB_MYCTO;  I6YC03, EPHB_MYCTU;  O33283, EPHG_MYCTU;  
Q9H6B9, EPHX3_HUMAN;  Q3V1F8, EPHX3_MOUSE;  Q0IIS3, EPHX3_XENTR;  
P80048, HYEP_PSEU1;  Q06816, HYEP_STIAD;  O52866, HYES_CORS2;  
P34913, HYES_HUMAN;  P34914, HYES_MOUSE;  Q6Q2C2, HYES_PIG;  
P80299, HYES_RAT;  A5DME6, LKA41_PICGU;  A3LRX6, LKA41_PICST;  
A5DGF3, LKA42_PICGU;  A3LQI7, LKA42_PICST;  A6RCT2, LKHA4_AJECN;  
Q9FY49, LKHA4_ARATH;  Q75B10, LKHA4_ASHGO;  A1CSI2, LKHA4_ASPCL;  
Q4X265, LKHA4_ASPFU;  A2QKF8, LKHA4_ASPNC;  Q2TZ99, LKHA4_ASPOR;  
Q0CFY9, LKHA4_ASPTN;  Q59NB8, LKHA4_CANAL;  Q6FTM0, LKHA4_CANGA;  
Q2GY21, LKHA4_CHAGB;  Q1DVD1, LKHA4_COCIM;  Q6BW21, LKHA4_DEBHA;  
P52922, LKHA4_DICDI;  Q5B0W8, LKHA4_EMENI;  Q6CLD3, LKHA4_KLULA;  
A5DSS4, LKHA4_LODEL;  A4QUC1, LKHA4_MAGO7;  A1DG68, LKHA4_NEOFI;  
Q7S785, LKHA4_NEUCR;  Q84TA3, LKHA4_ORYSJ;  Q0U653, LKHA4_PHANO;  
O94544, LKHA4_SCHPO;  A7EJL9, LKHA4_SCLS1;  A7THG7, LKHA4_VANPO;  
Q6C3E5, LKHA4_YARLI;  A6ZS33, LKHA4_YEAS7;  Q10740, LKHA4_YEAST;  

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All UniProtKB/Swiss-Prot entries referenced in this entry, with possibility to download in different formats, align etc.
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 3.3.2.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 3.3.-.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 3.-.-.-