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ENZYME

ENZYME entry: EC 3.3.2.10

Accepted Name
soluble epoxide hydrolase
Alternative Name(s)
arene-oxide hydratase
aryl epoxide hydrase
cytosolic epoxide hydrolase
epoxide hydrase
epoxide hydratase
trans-stilbene oxide hydrolase
Reaction catalysed
an epoxide + H2O <=> an ethanediol
Comment(s)
  • Catalyzes the hydrolysis of trans-substituted epoxides, such as trans-stilbene oxide, as well as various aliphatic epoxides derived from fatty-acid metabolism.
  • It is involved in the metabolism of arachidonic epoxides (epoxyeicosatrienoic acids; EETs) and linoleic acid epoxides.
  • The enzyme from mammals is a bifunctional enzyme: the C-terminal domain exhibits epoxide-hydrolase activity and the N-terminal domain has the activity of EC 3.1.3.76.
  • Like EC 3.3.2.9, it is probable that the reaction involves the formation of an hydroxyalkyl-enzyme intermediate.
  • The enzyme can also use leukotriene A4, the substrate of EC 3.3.2.6, but it forms 5,6-dihydroxy-7,9,11,14-eicosatetraenoic acid rather than leukotriene B4 as the product.
  • Formerly EC 3.3.2.3, EC 4.2.1.63 and EC 4.2.1.64.
Cross-references
BRENDA3.3.2.10
EC2PDB3.3.2.10
ExplorEnz3.3.2.10
PRIAM enzyme-specific profiles3.3.2.10
KEGG Ligand Database for Enzyme Nomenclature3.3.2.10
IUBMB Enzyme Nomenclature3.3.2.10
IntEnz3.3.2.10
MEDLINEFind literature relating to 3.3.2.10
MetaCyc3.3.2.10
Rhea expert-curated reactions3.3.2.10
UniProtKB/Swiss-Prot
G5EBI4, CEEH1_CAEELG5EDL5, CEEH2_CAEELI6YGS0, EPHA_MYCTU
P95276, EPHB_MYCTOI6YC03, EPHB_MYCTUO33283, EPHG_MYCTU
O53388, EPHH_MYCTUQ9H6B9, EPHX3_HUMANQ3V1F8, EPHX3_MOUSE
Q0IIS3, EPHX3_XENTRP80048, HYEP_PSEU1Q06816, HYEP_STIAD
O52866, HYES_CORS2P34913, HYES_HUMANP34914, HYES_MOUSE
Q6Q2C2, HYES_PIGP80299, HYES_RATA5DME6, LKA41_PICGU
A3LRX6, LKA41_PICSTA5DGF3, LKA42_PICGUA3LQI7, LKA42_PICST
A6RCT2, LKHA4_AJECNQ9FY49, LKHA4_ARATHA1CSI2, LKHA4_ASPCL
Q4X265, LKHA4_ASPFUA2QKF8, LKHA4_ASPNCQ2TZ99, LKHA4_ASPOR
Q0CFY9, LKHA4_ASPTNQ59NB8, LKHA4_CANALQ6FTM0, LKHA4_CANGA
Q2GY21, LKHA4_CHAGBQ1DVD1, LKHA4_COCIMQ6BW21, LKHA4_DEBHA
P52922, LKHA4_DICDIQ5B0W8, LKHA4_EMENIQ75B10, LKHA4_EREGS
Q6CLD3, LKHA4_KLULAA5DSS4, LKHA4_LODELA4QUC1, LKHA4_MAGO7
A1DG68, LKHA4_NEOFIQ7S785, LKHA4_NEUCRQ84TA3, LKHA4_ORYSJ
Q0U653, LKHA4_PHANOO94544, LKHA4_SCHPOA7EJL9, LKHA4_SCLS1
A7THG7, LKHA4_VANPOQ6C3E5, LKHA4_YARLIA6ZS33, LKHA4_YEAS7
Q10740, LKHA4_YEAST

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All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 3.3.2.-
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