A new class EC 7, Translocases, has been added to the EC list. It will be part of ENZYME from release 2018_10. Read more about EC 7 here.

ENZYME entry: EC 3.3.2.9

Accepted Name
Microsomal epoxide hydrolase.
Alternative Name(s)
Arene-oxide hydratase.
Aryl epoxide hydrase.
Benzo[a]pyrene-4,5-oxide hydratase.
Cis-epoxide hydrolase.
Epoxide hydrase.
Epoxide hydratase.
MEH.
Microsomal epoxide hydrase.
Microsomal epoxide hydratase.
Microsomal oxirane/oxetane hydrolase.
Reaction catalysed
  • Cis-stilbene oxide + H(2)O <=> (1R,2R)-1,2-diphenylethane-1,2-diol
  • 1-(4-methoxyphenyl)-N-methyl-N-((3-methyloxetan-3-yl)methyl)methanamine + H(2)O <=> 2-((((4-methoxyphenyl)methyl)(methyl)amino)methyl)-2-methylpropane-1,3-diol
Comment(s)
  • This is a key hepatic enzyme that catalyzes the hydrolytic ring opening of oxiranes (epoxides) and oxetanes to give the corresponding diols.
  • The enzyme is involved in the metabolism of numerous substrates including the stereoselective hydrolytic ring opening of 7-oxabicyclo(4.1.0)hepta-2,4-dienes (arene oxides) to the corresponding trans-dihydrodiols.
  • The reaction proceeds via a triad mechanism and involves the formation of an hydroxyalkyl-enzyme intermediate.
  • Five epoxide-hydrolase enzymes have been identified in vertebrates to date: EC 3.3.2.6, EC 3.3.2.7, EC 3.3.2.9, EC 3.3.2.10 and EC 3.3.2.11.
Cross-references
BRENDA3.3.2.9
EC2PDB3.3.2.9
ExplorEnz3.3.2.9
PRIAM enzyme-specific profiles3.3.2.9
KEGG Ligand Database for Enzyme Nomenclature3.3.2.9
IUBMB Enzyme Nomenclature3.3.2.9
IntEnz3.3.2.9
MEDLINEFind literature relating to 3.3.2.9
MetaCyc3.3.2.9
UniProtKB/Swiss-Prot
Q8MZR6, HYEP1_CTEFE;  Q8MZR5, HYEP2_CTEFE;  Q6U6J0, HYEP_BOMMO;  
P07099, HYEP_HUMAN;  Q25489, HYEP_MANSE;  Q9D379, HYEP_MOUSE;  
P79381, HYEP_PIG;  P04068, HYEP_RABIT;  P07687, HYEP_RAT;  

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All UniProtKB/Swiss-Prot entries referenced in this entry, with possibility to download in different formats, align etc.
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 3.3.2.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 3.3.-.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 3.-.-.-