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ENZYME entry: EC 3.3.2.9

Accepted Name
microsomal epoxide hydrolase.
Alternative Name(s)
arene-oxide hydratase.
aryl epoxide hydrase.
benzo[a]pyrene-4,5-oxide hydratase.
cis-epoxide hydrolase.
epoxide hydrase.
epoxide hydratase.
mEH.
microsomal epoxide hydrase.
microsomal epoxide hydratase.
microsomal oxirane/oxetane hydrolase.
Reaction catalysed
  • cis-stilbene oxide + H2O <=> (1R,2R)-hydrobenzoin
  • 1-(4-methoxyphenyl)-N-methyl-N-[(3-methyloxetan-3-yl)methyl]methanamine + H2O <=> 2-{[(4-methoxybenzyl)(methyl)amino]methyl}-2-methylpropane-1,3-diol
Comment(s)
  • This is a key hepatic enzyme that catalyzes the hydrolytic ring opening of oxiranes (epoxides) and oxetanes to give the corresponding diols.
  • The enzyme is involved in the metabolism of numerous substrates including the stereoselective hydrolytic ring opening of 7-oxabicyclo[4.1.0]hepta-2,4-dienes (arene oxides) to the corresponding trans-dihydrodiols.
  • The reaction proceeds via a triad mechanism and involves the formation of an hydroxyalkyl-enzyme intermediate.
  • Five epoxide-hydrolase enzymes have been identified in vertebrates to date: EC 3.3.2.6, EC 3.3.2.7, EC 3.3.2.9, EC 3.3.2.10 and EC 3.3.2.11.
  • Formerly EC 3.3.2.3, EC 4.2.1.63 and EC 4.2.1.64.
Cross-references
BRENDA3.3.2.9
EC2PDB3.3.2.9
ExplorEnz3.3.2.9
PRIAM enzyme-specific profiles3.3.2.9
KEGG Ligand Database for Enzyme Nomenclature3.3.2.9
IUBMB Enzyme Nomenclature3.3.2.9
IntEnz3.3.2.9
MEDLINEFind literature relating to 3.3.2.9
MetaCyc3.3.2.9
Rhea expert-curated reactions3.3.2.9
UniProtKB/Swiss-Prot
Q8MZR6, HYEP1_CTEFE;  Q8MZR5, HYEP2_CTEFE;  Q6U6J0, HYEP_BOMMO;  
P07099, HYEP_HUMAN;  Q25489, HYEP_MANSE;  Q9D379, HYEP_MOUSE;  
P79381, HYEP_PIG;  P04068, HYEP_RABIT;  P07687, HYEP_RAT;  

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