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ENZYME entry: EC 4.1.1.21

Accepted Name
phosphoribosylaminoimidazole carboxylase.
Alternative Name(s)
1-(5-phosphoribosyl)-5-amino-4-imidazolecarboxylate carboxy-lyase.
5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate carboxy-lyase.
5-amino-1-ribosylimidazole 5-phosphate carboxylase.
5-phosphoribosyl-5-aminoimidazole carboxylase.
AIR carboxylase.
Reaction catalysed
5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate + H(+) <=> 5-amino-1-(5-phospho-beta-D-ribosyl)imidazole + CO2
Comment(s)
  • While this is the reaction that occurs in vertebrates during purine biosynthesis, two enzymes are required to carry out the same reaction in Escherichia coli, namely EC 6.3.4.18 and EC 5.4.99.18.
  • 5-Carboxyamino-1-(5-phospho-D-ribosyl)imidazole is not a substrate.
Cross-references
BRENDA4.1.1.21
EC2PDB4.1.1.21
ExplorEnz4.1.1.21
PRIAM enzyme-specific profiles4.1.1.21
KEGG Ligand Database for Enzyme Nomenclature4.1.1.21
IUBMB Enzyme Nomenclature4.1.1.21
IntEnz4.1.1.21
MEDLINEFind literature relating to 4.1.1.21
MetaCyc4.1.1.21
Rhea expert-curated reactions4.1.1.21
UniProtKB/Swiss-Prot
Q10457, PUR6_CAEEL;  Q92210, PUR6_CANAL;  O74197, PUR6_CANGA;  
P38024, PUR6_CHICK;  P0CQ37, PUR6_CRYNB;  P0C017, PUR6_CRYNH;  
P0CQ36, PUR6_CRYNJ;  Q9I7S8, PUR6_DROME;  P22234, PUR6_HUMAN;  
Q9DCL9, PUR6_MOUSE;  Q01930, PUR6_OGAME;  Q5RB59, PUR6_PONAB;  
P51583, PUR6_RAT;  P50504, PUR6_SCHOC;  P15567, PUR6_SCHPO;  
P55195, PUR6_VIGAC;  P21264, PUR6_YEAST;  Q54QE4, PURCE_DICDI;  
O28997, PURE_ARCFU;  Q73PV9, PURE_TREDE;  

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