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ENZYME

ENZYME entry: EC 4.1.1.21

Accepted Name
phosphoribosylaminoimidazole carboxylase
Alternative Name(s)
1-(5-phosphoribosyl)-5-amino-4-imidazolecarboxylate carboxy-lyase
5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate carboxy-lyase
5-amino-1-ribosylimidazole 5-phosphate carboxylase
5-phosphoribosyl-5-aminoimidazole carboxylase
AIR carboxylase
Reaction catalysed
5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate + H(+) = 5-amino-1-(5-phospho-beta-D-ribosyl)imidazole + CO2
Comment(s)
  • While this is the reaction that occurs in vertebrates during purine biosynthesis, two enzymes are required to carry out the same reaction in Escherichia coli, namely EC 6.3.4.18 and EC 5.4.99.18.
  • 5-Carboxyamino-1-(5-phospho-D-ribosyl)imidazole is not a substrate.
Cross-references
BRENDA4.1.1.21
EC2PDB4.1.1.21
ExplorEnz4.1.1.21
KEGG Ligand Database for Enzyme Nomenclature4.1.1.21
IUBMB Enzyme Nomenclature4.1.1.21
MEDLINEFind literature relating to 4.1.1.21
MetaCyc4.1.1.21
Rhea expert-curated reactions4.1.1.21
UniProtKB/Swiss-Prot
Q10457, PUR6_CAEELQ92210, PUR6_CANALO74197, PUR6_CANGA
P38024, PUR6_CHICKP0CQ37, PUR6_CRYNBP0C017, PUR6_CRYNH
P0CQ36, PUR6_CRYNJQ9I7S8, PUR6_DROMEP22234, PUR6_HUMAN
Q9DCL9, PUR6_MOUSEQ01930, PUR6_OGAMEQ5RB59, PUR6_PONAB
P51583, PUR6_RATP50504, PUR6_SCHOCP15567, PUR6_SCHPO
P55195, PUR6_VIGACP21264, PUR6_YEASTQ54QE4, PURCE_DICDI
O28997, PURE_ARCFUQ73PV9, PURE_TREDE

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