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A new class EC 7, Translocases, has been added to the EC list. It will be part of ENZYME from release 2018_10. Read more about EC 7 here.

ENZYME entry: EC 4.1.1.21

Accepted Name
Phosphoribosylaminoimidazole carboxylase.
Alternative Name(s)
1-(5-phosphoribosyl)-5-amino-4-imidazolecarboxylate carboxy-lyase.
5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate carboxy-lyase.
5-amino-1-ribosylimidazole 5-phosphate carboxylase.
5-phosphoribosyl-5-aminoimidazole carboxylase.
AIR carboxylase.
Reaction catalysed
5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate <=> 5-amino-1-(5-phospho-D-ribosyl)imidazole + CO(2)
Comment(s)
  • While this is the reaction that occurs in vertebrates during purine biosynthesis, two enzymes are required to carry out the same reaction in Escherichia coli, namely EC 6.3.4.18 and EC 5.4.99.18.
  • 5-carboxyamino-1-(5-phospho-D-ribosyl)imidazole is not a substrate.
Cross-references
PROSITEPDOC50975
BRENDA4.1.1.21
EC2PDB4.1.1.21
ExplorEnz4.1.1.21
PRIAM enzyme-specific profiles4.1.1.21
KEGG Ligand Database for Enzyme Nomenclature4.1.1.21
IUBMB Enzyme Nomenclature4.1.1.21
IntEnz4.1.1.21
MEDLINEFind literature relating to 4.1.1.21
MetaCyc4.1.1.21
UniProtKB/Swiss-Prot
Q10457, PUR6_CAEEL;  Q92210, PUR6_CANAL;  O74197, PUR6_CANGA;  
P38024, PUR6_CHICK;  P0CQ37, PUR6_CRYNB;  P0C017, PUR6_CRYNH;  
P0CQ36, PUR6_CRYNJ;  Q9I7S8, PUR6_DROME;  P22234, PUR6_HUMAN;  
Q9DCL9, PUR6_MOUSE;  Q01930, PUR6_OGAME;  Q5RB59, PUR6_PONAB;  
P51583, PUR6_RAT;  P50504, PUR6_SCHOC;  P15567, PUR6_SCHPO;  
P55195, PUR6_VIGAC;  P21264, PUR6_YEAST;  Q54QE4, PURCE_DICDI;  
O28997, PURE_ARCFU;  Q73PV9, PURE_TREDE;  

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All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 4.1.1.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 4.1.-.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 4.-.-.-