A new class EC 7, Translocases, has been added to the EC list. It will be part of ENZYME from release 2018_09. Read more about EC 7 here.

ENZYME entry: EC 5.4.99.18

Accepted Name
5-(carboxyamino)imidazole ribonucleotide mutase.
Alternative Name(s)
N(5)-CAIR mutase.
N(5)-carboxyaminoimidazole ribonucleotide mutase.
Reaction catalysed
5-carboxyamino-1-(5-phospho-D-ribosyl)imidazole <=> 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxylate
Comment(s)
  • In eubacteria, fungi and plants, this enzyme, along with EC 6.3.4.18, is required to carry out the single reaction catalyzed by EC 4.1.1.21 in vertebrates.
  • In the absence of EC 6.3.2.6, the reaction is reversible.
  • The substrate is readily converted into 5-amino-1-(5-phospho-D- ribosyl)imidazole by non-enzymic decarboxylation.
Cross-references
BRENDA5.4.99.18
EC2PDB5.4.99.18
ExplorEnz5.4.99.18
PRIAM enzyme-specific profiles5.4.99.18
KEGG Ligand Database for Enzyme Nomenclature5.4.99.18
IUBMB Enzyme Nomenclature5.4.99.18
IntEnz5.4.99.18
MEDLINEFind literature relating to 5.4.99.18
MetaCyc5.4.99.18
UniProtKB/Swiss-Prot
Q5E1R4, PURE_ALIF1;  O67239, PURE_AQUAE;  P12044, PURE_BACSU;  
P52558, PURE_BRUME;  Q8FYW3, PURE_BRUSU;  Q44679, PURE_CORAM;  
P0AG19, PURE_ECO57;  P0AG18, PURE_ECOLI;  P43849, PURE_HAEIN;  
Q58033, PURE_METJA;  P22348, PURE_METSM;  P41654, PURE_METTH;  
P46702, PURE_MYCLE;  P9WHM0, PURE_MYCTO;  P9WHM1, PURE_MYCTU;  
P72157, PURE_PSEAE;  Q9UY68, PURE_PYRAB;  O58058, PURE_PYRHO;  
O06456, PURE_SULSO;  Q55498, PURE_SYNY3;  Q9WYS7, PURE_THEMA;  
Q9KVT7, PURE_VIBCH;  Q87KE1, PURE_VIBPA;  Q8DDD7, PURE_VIBVU;  
Q7MGL2, PURE_VIBVY;  

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All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 5.4.99.-
All ENZYME / UniProtKB/Swiss-Prot entries corresponding to 5.4.-.-
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