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ENZYME

ENZYME entry: EC 6.3.4.18

PURL: https://purl.expasy.org/enzyme/EC/6.3.4.18
Accepted Name
5-(carboxyamino)imidazole ribonucleotide synthase
Alternative Name(s)
N(5)-CAIR synthetase
N(5)-carboxyaminoimidazole ribonucleotide synthetase
Reaction catalysed
5-amino-1-(5-phospho-beta-D-ribosyl)imidazole + hydrogencarbonate + ATP = 5-carboxyamino-1-(5-phospho-D-ribosyl)imidazole + ADP + phosphate + 2 H(+)
Comment(s)
  • In Escherichia coli, this enzyme, along with EC 5.4.99.18, is required to carry out the single reaction catalyzed by EC 4.1.1.21 in vertebrates.
  • Carboxyphosphate is the putative acyl phosphate intermediate.
  • Involved in the late stages of purine biosynthesis.
Cross-references
BRENDA6.3.4.18
EC2PDB6.3.4.18
ExplorEnz6.3.4.18
KEGG Ligand Database for Enzyme Nomenclature6.3.4.18
IUBMB Enzyme Nomenclature6.3.4.18
MEDLINEFind literature relating to 6.3.4.18
MetaCyc6.3.4.18
Rhea expert-curated reactions6.3.4.18
UniProtKB/Swiss-Prot
Q5E1R3, PURK_ALIF1O66608, PURK_AQUAEP12045, PURK_BACSU
P52559, PURK_BRUMEQ44678, PURK_CORAMP09029, PURK_ECOLI
P43850, PURK_HAEINP65899, PURK_MYCBOP46701, PURK_MYCLE
P9WHL8, PURK_MYCTOP9WHL9, PURK_MYCTUP72158, PURK_PSEAE
O06457, PURK_SACS2Q5HH19, PURK_STAACQ99V32, PURK_STAAM
Q7A695, PURK_STAANQ6GI19, PURK_STAARQ6GAE8, PURK_STAAS
Q8NX94, PURK_STAAWQ5HQA5, PURK_STAEQQ8CPP2, PURK_STAES
Q4L574, PURK_STAHJQ49WI9, PURK_STAS1Q54975, PURK_SYNE7
P74724, PURK_SYNY3Q9KVT8, PURK_VIBCHQ87KE0, PURK_VIBPA
Q8DDD8, PURK_VIBVUQ7MGL1, PURK_VIBVY

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