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ENZYME

ENZYME entry: EC 4.1.99.1

Accepted Name
tryptophanase
Alternative Name(s)
L-tryptophan indole-lyase
TNase
Reaction catalysed
H2O + L-tryptophan <=> indole + NH4(+) + pyruvate
Comment(s)
  • The enzyme cleaves a carbon-carbon bond, releasing indole and an unstable enamine product that tautomerizes to an imine form, which undergoes a hydrolytic deamination to form pyruvate and ammonia.
  • The latter reaction, which can occur spontaneously, can also be catalyzed by EC 3.5.99.10.
  • Also catalyzes 2,3-elimination and beta-replacement reactions of some indole-substituted tryptophan analogs of L-cysteine, L-serine and other 3-substituted amino acids.
Cross-references
BRENDA4.1.99.1
EC2PDB4.1.99.1
ExplorEnz4.1.99.1
PRIAM enzyme-specific profiles4.1.99.1
KEGG Ligand Database for Enzyme Nomenclature4.1.99.1
IUBMB Enzyme Nomenclature4.1.99.1
IntEnz4.1.99.1
MEDLINEFind literature relating to 4.1.99.1
MetaCyc4.1.99.1
Rhea expert-curated reactions4.1.99.1
UniProtKB/Swiss-Prot
P31014, TNAA1_SYMTHP31015, TNAA2_SYMTHA0KJP3, TNAA_AERHH
Q9YCI2, TNAA_AERPEA4SNA7, TNAA_AERS4Q8R9K5, TNAA_CALS4
Q7NYV9, TNAA_CHRVOA8AKE2, TNAA_CITK8Q894M8, TNAA_CLOTE
A7ZTR3, TNAA_ECO24B7UMH5, TNAA_ECO27B7MGC9, TNAA_ECO45
B7L853, TNAA_ECO55Q8XB34, TNAA_ECO57B5YXB2, TNAA_ECO5E
B7NR10, TNAA_ECO7IB7N212, TNAA_ECO81B7M560, TNAA_ECO8A
C4ZYY6, TNAA_ECOBWB1X9T7, TNAA_ECODHA8A6H0, TNAA_ECOHS
Q0TB00, TNAA_ECOL5Q8FBV2, TNAA_ECOL6B1IX30, TNAA_ECOLC
P0A853, TNAA_ECOLIB7NF25, TNAA_ECOLUB6I3U1, TNAA_ECOSE
B1LL35, TNAA_ECOSMB7LK50, TNAA_ESCF3Q4QML4, TNAA_HAEI8
O07674, TNAA_HAEIFB0R7Q6, TNAA_HALS3Q9HMV2, TNAA_HALSA
Q0I3R5, TNAA_HISS1B0UTZ3, TNAA_HISS2Q0C406, TNAA_HYPNA
Q59342, TNAA_KLEAEQ729Z3, TNAA_NITV2A1VC86, TNAA_NITV4
Q9CL27, TNAA_PASMUQ7N8C9, TNAA_PHOLLQ9ZNA8, TNAA_PROIN
P28796, TNAA_PROVUO30971, TNAA_RHOCAQ2S1V4, TNAA_SALRD
A8G097, TNAA_SHESHB2TUR7, TNAA_SHIB3Q0SYP7, TNAA_SHIF8
P0A854, TNAA_SHIFLA5EYI0, TNAA_VIBC3Q9KN05, TNAA_VIBCH
C3LUI5, TNAA_VIBCMQ87JQ6, TNAA_VIBPAQ8D5Q4, TNAA_VIBVU
Q7MCR1, TNAA_VIBVYA1JJH3, TNAA_YERE8

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